Literature DB >> 35679588

Screen for Small-Molecule Modulators of Circadian Rhythms Reveals Phenazine as a Redox-State Modifying Clockwork Tuner.

Kevin P Kelly1, Hugo Borsetti1, Marta E Wenzler2, Alessandro Ustione3, Kwangho Kim2,4, Plamen P Christov4, Bianca Ramirez2, Joshua A Bauer4,5, David W Piston3, Carl Hirschie Johnson1,4, Gary A Sulikowski2,4.   

Abstract

A high-throughput cell-based screen identified redox-active small molecules that produce a period lengthening of the circadian rhythm. The strongest period lengthening phenotype was induced by a phenazine carboxamide (VU661). Comparison to two isomeric benzquinoline carboxamides (VU673 and VU164) shows the activity is associated with the redox modulating phenazine functionality. Furthermore, ex vivo cell analysis using optical redox ratio measurements shows the period lengthening phenotype to be associated with a shift to the NAD/FAD oxidation state of nicotinamide and flavine coenzymes.

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Year:  2022        PMID： 35679588      PMCID： PMC9398883          DOI： 10.1021/acschembio.2c00240

Source DB:  PubMed          Journal:  ACS Chem Biol        ISSN： 1554-8929            Impact factor:   4.634


  44 in total

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5.  Resetting central and peripheral circadian oscillators in transgenic rats.

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7.  Circadian control of the NAD+ salvage pathway by CLOCK-SIRT1.

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Review 8.  Transcriptional architecture of the mammalian circadian clock.

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10.  Peroxiredoxins are conserved markers of circadian rhythms.

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Journal:  Nature       Date:  2012-05-16       Impact factor: 49.962
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