Marcela Tamayo Y Ortiz1, Martha María Téllez-Rojo2, Belem Trejo-Valdivia3, Lourdes Schnaas4, Erika Osorio-Valencia5, Brent Coull6, David Bellinger7, Rosalind J Wright8, Robert O Wright9. 1. National Council of Science and Technology, Avenida Insurgentes Sur 1582, Benito Juárez, Crédito Constructor, 03940 Ciudad de México, D.F., México. Electronic address: mtamayo@hsph.harvard.edu. 2. National Institute of Public Health, Universidad No. 655 Colonia Santa María, Ahuacatitlán, Cerrada Los Pinos y Caminera, C.P. 62100, Cuernavaca, Morelos, México. Electronic address: mmtellez@insp.mx. 3. National Institute of Public Health, Universidad No. 655 Colonia Santa María, Ahuacatitlán, Cerrada Los Pinos y Caminera, C.P. 62100, Cuernavaca, Morelos, México. Electronic address: bvaldivia@insp.mx. 4. National Institute of Perinatology, Calle Montes Urales #800, Miguel Hidalgo, Lomas Virreyes, 11000 Ciudad de México, D.F., México. Electronic address: lschnaas@hotmail.com. 5. National Institute of Perinatology, Calle Montes Urales #800, Miguel Hidalgo, Lomas Virreyes, 11000 Ciudad de México, D.F., México. Electronic address: erikaosorio4@hotmail.com. 6. Department of Biostatistics, Harvard T.H. Chan School of Public Health, 677 Huntington Ave, Boston, MA 02115, United States. Electronic address: bcoull@hsph.harvard.edu. 7. Department Environmental Health, Harvard T.H. Chan School of Public Health, 677 Huntington Ave, Boston, MA 02115, United States. Electronic address: david.bellinger@childrens.harvard.edu. 8. Department of Pediatrics, Icahn School of Medicine at Mount Sinai, 1428 Madison Ave, New York, NY 10029, United States. Electronic address: rosalind.wright@mssm.edu. 9. Department of Preventive Medicine, Icahn School of Medicine at Mount Sinai, 1428 Madison Ave, New York, NY 10029, United States. Electronic address: robert.wright@mssm.edu.
Abstract
BACKGROUND: Lead and psychosocial stress disrupt similar but not completely overlapping mechanisms. Exposure during the prenatal period to each of these insults singularly has been found to alter normal neurodevelopment; however, longitudinal associations with stress modifying the effect of lead have not been sufficiently analyzed in epidemiologic studies. OBJECTIVE: To evaluate prenatal stress as an effect modifier of gestational lead neurotoxicity. METHODS: We used a structural equations modeling approach with a trivariate response to evaluate cognitive, language and motor scores of the Bayley Scales of Infant Development-III in 24month-old children (n=360). Maternal blood lead levels were measured at the 2nd and 3rd trimester and psychosocial stress during pregnancy was assessed using a negative life events (NLE) scale derived from the CRYSIS questionnaire. RESULTS: 3rd trimester lead (mean 3.9±3.0 SDμg/dL) and stress (median=3 NLE) were negatively associated with Bayley III scores. Using the model's results we generated profiles for 0, 2, 4 and 6 NLE across lead levels (up to 10μg/dL) and observed a dose-response for the developmental scores when lead levels were below 2μg/dL. Each NLE curve had a different shape across increasing lead levels. Higher stress (NLE=6) resulted in lower cognitive scores for both sexes, in lower language scores in girls but not boys. In the absence of stress we saw a negative association with lead for all scores, however for language and motor scores, higher stress seemed to mask this association. CONCLUSIONS: Our work examined and confirmed prenatal stress exposure as a modifier of the well-known neurotoxic effects of prenatal lead. It adds to the existing evidence pointing at the importance of studying the co-exposure of chemical and non-chemical exposures, specifically of considering the emotional environment of children at early developmental stages of life. Copyright Â
BACKGROUND: Lead and psychosocial stress disrupt similar but not completely overlapping mechanisms. Exposure during the prenatal period to each of these insults singularly has been found to alter normal neurodevelopment; however, longitudinal associations with stress modifying the effect of lead have not been sufficiently analyzed in epidemiologic studies. OBJECTIVE: To evaluate prenatal stress as an effect modifier of gestational lead neurotoxicity. METHODS: We used a structural equations modeling approach with a trivariate response to evaluate cognitive, language and motor scores of the Bayley Scales of Infant Development-III in 24month-old children (n=360). Maternal blood lead levels were measured at the 2nd and 3rd trimester and psychosocial stress during pregnancy was assessed using a negative life events (NLE) scale derived from the CRYSIS questionnaire. RESULTS: 3rd trimester lead (mean 3.9±3.0 SDμg/dL) and stress (median=3 NLE) were negatively associated with Bayley III scores. Using the model's results we generated profiles for 0, 2, 4 and 6 NLE across lead levels (up to 10μg/dL) and observed a dose-response for the developmental scores when lead levels were below 2μg/dL. Each NLE curve had a different shape across increasing lead levels. Higher stress (NLE=6) resulted in lower cognitive scores for both sexes, in lower language scores in girls but not boys. In the absence of stress we saw a negative association with lead for all scores, however for language and motor scores, higher stress seemed to mask this association. CONCLUSIONS: Our work examined and confirmed prenatal stress exposure as a modifier of the well-known neurotoxic effects of prenatal lead. It adds to the existing evidence pointing at the importance of studying the co-exposure of chemical and non-chemical exposures, specifically of considering the emotional environment of children at early developmental stages of life. Copyright Â
Authors: Héctor Lamadrid-Figueroa; Martha María Téllez-Rojo; Leticia Hernández-Cadena; Adriana Mercado-García; Donald Smith; Maritsa Solano-González; Mauricio Hernández-Avila; Howard Hu Journal: J Toxicol Environ Health A Date: 2006-10
Authors: Jack Caravanos; Russell Dowling; Martha María Téllez-Rojo; Alejandra Cantoral; Roni Kobrosly; Daniel Estrada; Manuela Orjuela; Sandra Gualtero; Bret Ericson; Anthony Rivera; Richard Fuller Journal: Ann Glob Health Date: 2014-11-25 Impact factor: 2.462
Authors: Elizabeth A Cromwell; Queen Dube; Stephen R Cole; Chawanangwa Chirambo; Anna E Dow; Robert S Heyderman; Annelies Van Rie Journal: Eur J Paediatr Neurol Date: 2013-12-31 Impact factor: 3.140
Authors: Pamela J Surkan; Lourdes Schnaas; Rosalind J Wright; Martha M Téllez-Rojo; Héctor Lamadrid-Figueroa; Howard Hu; Mauricio Hernández-Avila; David C Bellinger; Joel Schwartz; Estela Perroni; Robert O Wright Journal: Neurotoxicology Date: 2007-12-15 Impact factor: 4.294
Authors: Maitreyi Mazumdar; Weiming Xia; Oliver Hofmann; Matthew Gregas; Shannan Ho Sui; Winston Hide; Ting Yang; Herbert L Needleman; David C Bellinger Journal: Environ Health Perspect Date: 2012-02-07 Impact factor: 9.031
Authors: Hannah M C Schreier; Hsiao-Hsien Hsu; Chitra Amarasiriwardena; Brent A Coull; Lourdes Schnaas; Martha María Téllez-Rojo; Marcela Tamayo y Ortiz; Rosalind J Wright; Robert O Wright Journal: Environ Health Date: 2015-03-27 Impact factor: 5.984
Authors: Amy R Nichols; Andrew G Rundle; Pam Factor-Litvak; Beverly J Insel; Lori Hoepner; Virginia Rauh; Frederica Perera; Elizabeth M Widen Journal: J Dev Orig Health Dis Date: 2019-09-05 Impact factor: 2.401
Authors: Magali Hurtado-Díaz; Horacio Riojas-Rodríguez; Stephen J Rothenberg; Lourdes Schnaas-Arrieta; Itai Kloog; Allan Just; David Hernández-Bonilla; Robert O Wright; Martha Ma Téllez-Rojo Journal: Int J Hyg Environ Health Date: 2021-02-11 Impact factor: 5.840
Authors: Pahriya Ashrap; Amira Aker; Deborah J Watkins; Bhramar Mukherjee; Zaira Rosario-Pabón; Carmen M Vélez-Vega; Akram Alshawabkeh; José F Cordero; John D Meeker Journal: Environ Int Date: 2021-02-03 Impact factor: 13.352
Authors: Sara Sammallahti; Andrea P Cortes Hidalgo; Charlotte A M Cecil; Henning Tiemeier; Jari Lahti; Samuli Tuominen; Anni Malmberg; Rosa H Mulder; Kelly J Brunst; Silvia Alemany; Nancy S McBride; Paul Yousefi; Jonathan A Heiss; Nia McRae; Christian M Page; Jianping Jin; Giancarlo Pesce; Doretta Caramaschi; Sheryl L Rifas-Shiman; Nastassja Koen; Charleen D Adams; Maria C Magnus; Nour Baïz; Andrew Ratanatharathorn; Darina Czamara; Siri E Håberg; Elena Colicino; Andrea A Baccarelli; Andres Cardenas; Dawn L DeMeo; Deborah A Lawlor; Caroline L Relton; Janine F Felix; Marinus H van IJzendoorn; Marian J Bakermans-Kranenburg; Eero Kajantie; Katri Räikkönen; Jordi Sunyer; Gemma C Sharp; Lotte C Houtepen; Ellen A Nohr; Thorkild I A Sørensen; Martha M Téllez-Rojo; Robert O Wright; Isabella Annesi-Maesano; John Wright; Marie-France Hivert; Rosalind J Wright; Heather J Zar; Dan J Stein; Stephanie J London Journal: Mol Psychiatry Date: 2021-01-07 Impact factor: 13.437
Authors: Anne K Bozack; Elena Colicino; Rodosthenis Rodosthenous; Tessa R Bloomquist; Andrea A Baccarelli; Robert O Wright; Rosalind J Wright; Alison G Lee Journal: Epigenetics Date: 2020-08-25 Impact factor: 4.528
Authors: Ronnie Levin; Carolina L Zilli Vieira; Marieke H Rosenbaum; Karyn Bischoff; Daniel C Mordarski; Mary Jean Brown Journal: Environ Res Date: 2020-10-28 Impact factor: 8.431