Jian Xu1, Howard Hu2, Rosalind Wright3, Brisa N Sánchez4, Lourdes Schnaas5, David C Bellinger6, Sung Kyun Park7, Sandra Martínez5, Mauricio Hernández-Avila8, Martha Maria Téllez-Rojo8, Robert O Wright9. 1. Xinhua Hospital, MOE-Shanghai Key Laboratory of Children's Environmental Health, Department of Child and Adolescent Healthcare, Shanghai Institute for Pediatric Research, Shanghai Jiao Tong University School of Medicine, Shanghai, China. Electronic address: jxxinhuachina@gmail.com. 2. Dalla Lana School of Public Health, University of Toronto, Ontario, Canada; Department of Environmental Health Sciences, University of Michigan School of Public Health, Ann Arbor, MI. Electronic address: Howard.Hu@utoronto.ca. 3. Kravis Children's Hospital, Department of Pediatrics, Icahn School of Medicine at Mount Sinai, New York, NY; Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY. 4. Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, MI. 5. National Institute of Perinatology, Mexico City, Mexico. 6. Harvard Medical School, Harvard School of Public Health, Boston, MA. 7. Department of Environmental Health Sciences, University of Michigan School of Public Health, Ann Arbor, MI; Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, MI. 8. National Institute of Public Health, Cuernavaca, Morelos, Mexico. 9. Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY; Department of Preventive Medicine, Icahn School of Medicine at Mount Sinai, New York, NY.
Abstract
OBJECTIVE: To prospectively evaluate the association of maternal self-esteem measured when their offspring were toddlers with the subsequent development of attention deficit hyperactivity disorder (ADHD)-like behavior in their school-age offspring and the potential modifying effects of prenatal lead exposure. STUDY DESIGN: We evaluated a subsample of 192 mother-child pairs from a long-running birth-cohort project that enrolled mothers in Mexico from 1994-2011. Prenatal lead exposure was assessed using cord blood lead and maternal bone lead around delivery (tibia and patella lead, measured by K-x-ray-fluorescence). When children were 2 years old, maternal self-esteem was measured using the Coopersmith Self-Esteem Inventory. When children were 7-15 years old, children's blood lead levels and ADHD symptoms were assessed, and Conners' Parent Rating Scale-Revised and Behavior Rating Inventory of Executive Function-Parent Form were used as measures of ADHD-like behavior. RESULTS: Adjusting for family economic status, marital status, maternal education and age, child's age and sex, and children's current blood lead levels, increased maternal self-esteem was associated with reduced child inattention behavior. Compared with those among high prenatal lead exposure (P25-P100), this association was stronger among low prenatal lead exposure groups (P1-P25, P values for the interaction effects between prenatal lead exposure and maternal self-esteem levels of <.10). Each 1-point increase in maternal self-esteem scores was associated with 0.6- to 1.3-point decrease in Conners' Parent Rating Scale-Revised and Behavior Rating Inventory of Executive Function-Parent Form T-scores among groups with low cord blood lead and patella lead (P1-P25). CONCLUSIONS: Children experiencing high maternal self-esteem during toddlerhood were less likely to develop inattention behavior at school age. Prenatal lead exposure may play a role in attenuating this protective effect.
OBJECTIVE: To prospectively evaluate the association of maternal self-esteem measured when their offspring were toddlers with the subsequent development of attention deficit hyperactivity disorder (ADHD)-like behavior in their school-age offspring and the potential modifying effects of prenatal lead exposure. STUDY DESIGN: We evaluated a subsample of 192 mother-child pairs from a long-running birth-cohort project that enrolled mothers in Mexico from 1994-2011. Prenatal lead exposure was assessed using cord blood lead and maternal bone lead around delivery (tibia and patella lead, measured by K-x-ray-fluorescence). When children were 2 years old, maternal self-esteem was measured using the Coopersmith Self-Esteem Inventory. When children were 7-15 years old, children's blood lead levels and ADHD symptoms were assessed, and Conners' Parent Rating Scale-Revised and Behavior Rating Inventory of Executive Function-Parent Form were used as measures of ADHD-like behavior. RESULTS: Adjusting for family economic status, marital status, maternal education and age, child's age and sex, and children's current blood lead levels, increased maternal self-esteem was associated with reduced child inattention behavior. Compared with those among high prenatal lead exposure (P25-P100), this association was stronger among low prenatal lead exposure groups (P1-P25, P values for the interaction effects between prenatal lead exposure and maternal self-esteem levels of <.10). Each 1-point increase in maternal self-esteem scores was associated with 0.6- to 1.3-point decrease in Conners' Parent Rating Scale-Revised and Behavior Rating Inventory of Executive Function-Parent Form T-scores among groups with low cord blood lead and patella lead (P1-P25). CONCLUSIONS:Children experiencing high maternal self-esteem during toddlerhood were less likely to develop inattention behavior at school age. Prenatal lead exposure may play a role in attenuating this protective effect.
Authors: Tanya E Froehlich; Bruce P Lanphear; Peggy Auinger; Richard Hornung; Jeffery N Epstein; Joe Braun; Robert S Kahn Journal: Pediatrics Date: 2009-11-23 Impact factor: 7.124
Authors: Pamela J Surkan; Lourdes Schnaas; Rosalind J Wright; Martha M Téllez-Rojo; Héctor Lamadrid-Figueroa; Howard Hu; Mauricio Hernández-Avila; David C Bellinger; Joel Schwartz; Estela Perroni; Robert O Wright Journal: Neurotoxicology Date: 2007-12-15 Impact factor: 4.294
Authors: Adrienne S Ettinger; Héctor Lamadrid-Figueroa; Martha M Téllez-Rojo; Adriana Mercado-García; Karen E Peterson; Joel Schwartz; Howard Hu; Mauricio Hernández-Avila Journal: Environ Health Perspect Date: 2008-09-02 Impact factor: 9.031
Authors: Marcela Tamayo Y Ortiz; Martha María Téllez-Rojo; Belem Trejo-Valdivia; Lourdes Schnaas; Erika Osorio-Valencia; Brent Coull; David Bellinger; Rosalind J Wright; Robert O Wright Journal: Environ Int Date: 2016-11-16 Impact factor: 9.621