Magali Hurtado-Díaz1, Horacio Riojas-Rodríguez2, Stephen J Rothenberg3, Lourdes Schnaas-Arrieta4, Itai Kloog5, Allan Just6, David Hernández-Bonilla7, Robert O Wright8, Martha Ma Téllez-Rojo9. 1. Center for Population Health Research, National Institute of Public Health, Av. Universidad No. 655, Col. Sta. Ma. Ahuacatitlán, 62100, Cuernavaca, Morelos, Mexico. Electronic address: mhurtado@insp.mx. 2. Center for Population Health Research, National Institute of Public Health, Av. Universidad No. 655, Col. Sta. Ma. Ahuacatitlán, 62100, Cuernavaca, Morelos, Mexico. Electronic address: hriojas@insp.mx. 3. Center for Population Health Research, National Institute of Public Health, Av. Universidad No. 655, Col. Sta. Ma. Ahuacatitlán, 62100, Cuernavaca, Morelos, Mexico. Electronic address: drlead@prodigy.net.mx. 4. Department of Developmental Neurobiology, National Institute of Perinatology, Montes Urales 800 Col. Virreyes Deleg, Miguel Hidalgo D.F, C.P. 11000, USA. Electronic address: lschnaas@hotmail.com. 5. Department of Geography and Environmental Development, Ben-Gurion University of the Negev (BGU), Beer Sheva, Israel. Electronic address: ikloog@bgu.ac.il. 6. Department of Preventive Medicine, Icahn School of Medicine at Mount Sinai, 17 East 102 Street, Floor 3, Room 131, New York, NY, 10029, USA. Electronic address: allan.just@mssm.edu. 7. Center for Population Health Research, National Institute of Public Health, Av. Universidad No. 655, Col. Sta. Ma. Ahuacatitlán, 62100, Cuernavaca, Morelos, Mexico. Electronic address: david.hernandez@insp.mx. 8. Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, 17 East 102 Street Floor 3 West Room D3-110, New York, 10029, NY, USA. Electronic address: robert.wright@mssm.edu. 9. Center for Nutrition and Health Research, National Institute of Public Health, Av. Universidad No. 655, Col. Sta. Ma. Ahuacatitlán, 61200, Cuernavaca, Morelos, Mexico. Electronic address: mmtellez@insp.mx.
Abstract
BACKGROUND: Recent studies have reported that air pollution exposure may have neurotoxic properties. OBJECTIVE: To examine longitudinal associations between prenatal particles less than 2.5 μm in diameter (PM2.5) exposure and neurodevelopment during the first two years of children's life. METHODS: Analysis was conducted in PROGRESS, a longitudinal birth cohort between 2007 and 2013 in Mexico City. We used satellite data to predict daily PM2.5 concentrations at high spatial resolution. Multivariate mixed-effect regression models were adjusted to examine cognitive, language and motor scores in children up to 24 months of age (n = 740) and each trimester-specific and whole pregnancy exposure to PM2.5. RESULTS: Models adjusted by child sex, gestational age, birth weight, smoking and mother's IQ, showed that each increase of 1 μg/m3 of PM2.5 was associated with a decreased language function of -0.38 points (95% CI: -0.77, -0.01). PM2.5 exposure at third trimester of pregnancy contributed most to the observed association. CONCLUSION: Our findings suggest that language development up to 24 months of age may be particularly sensitive to PM2.5 exposure during pregnancy.
BACKGROUND: Recent studies have reported that air pollution exposure may have neurotoxic properties. OBJECTIVE: To examine longitudinal associations between prenatal particles less than 2.5 μm in diameter (PM2.5) exposure and neurodevelopment during the first two years of children's life. METHODS: Analysis was conducted in PROGRESS, a longitudinal birth cohort between 2007 and 2013 in Mexico City. We used satellite data to predict daily PM2.5 concentrations at high spatial resolution. Multivariate mixed-effect regression models were adjusted to examine cognitive, language and motor scores in children up to 24 months of age (n = 740) and each trimester-specific and whole pregnancy exposure to PM2.5. RESULTS: Models adjusted by child sex, gestational age, birth weight, smoking and mother's IQ, showed that each increase of 1 μg/m3 of PM2.5 was associated with a decreased language function of -0.38 points (95% CI: -0.77, -0.01). PM2.5 exposure at third trimester of pregnancy contributed most to the observed association. CONCLUSION: Our findings suggest that language development up to 24 months of age may be particularly sensitive to PM2.5 exposure during pregnancy.
Authors: Carolina Johansson; Anna F Castoldi; Natalia Onishchenko; Luigi Manzo; Marie Vahter; Sandra Ceccatelli Journal: Neurotox Res Date: 2007-04 Impact factor: 3.911
Authors: Allan C Just; Robert O Wright; Joel Schwartz; Brent A Coull; Andrea A Baccarelli; Martha María Tellez-Rojo; Emily Moody; Yujie Wang; Alexei Lyapustin; Itai Kloog Journal: Environ Sci Technol Date: 2015-06-26 Impact factor: 9.028
Authors: Mònica Guxens; Raquel Garcia-Esteban; Lise Giorgis-Allemand; Joan Forns; Chiara Badaloni; Ferran Ballester; Rob Beelen; Giulia Cesaroni; Leda Chatzi; Maria de Agostini; Audrey de Nazelle; Marloes Eeftens; Mariana F Fernandez; Ana Fernández-Somoano; Francesco Forastiere; Ulrike Gehring; Akhgar Ghassabian; Barbara Heude; Vincent W V Jaddoe; Claudia Klümper; Manolis Kogevinas; Ursula Krämer; Béatrice Larroque; Aitana Lertxundi; Nerea Lertxuni; Mario Murcia; Vladislav Navel; Mark Nieuwenhuijsen; Daniela Porta; Rosa Ramos; Theano Roumeliotaki; Rémy Slama; Mette Sørensen; Euripides G Stephanou; Dorothea Sugiri; Adonina Tardón; Henning Tiemeier; Carla M T Tiesler; Frank C Verhulst; Tanja Vrijkotte; Michael Wilhelm; Bert Brunekreef; Göran Pershagen; Jordi Sunyer Journal: Epidemiology Date: 2014-09 Impact factor: 4.822
Authors: R Guerra; E Vera-Aguilar; M Uribe-Ramirez; G Gookin; J Camacho; A R Osornio-Vargas; V Mugica-Alvarez; R Angulo-Olais; A Campbell; J Froines; T M Kleinman; A De Vizcaya-Ruiz Journal: Toxicol Lett Date: 2013-07-26 Impact factor: 4.372
Authors: Yueh-Hsiu Mathilda Chiu; Hsiao-Hsien Leon Hsu; Brent A Coull; David C Bellinger; Itai Kloog; Joel Schwartz; Robert O Wright; Rosalind J Wright Journal: Environ Int Date: 2015-11-28 Impact factor: 9.621
Authors: Luisa Torres-Sánchez; Stephen J Rothenberg; Lourdes Schnaas; Mariano E Cebrián; Erika Osorio; Maria Del Carmen Hernández; Rosa M García-Hernández; Constanza Del Rio-Garcia; Mary S Wolff; Lizbeth López-Carrillo Journal: Environ Health Perspect Date: 2007-01-16 Impact factor: 9.031
Authors: Laura A McGuinn; David C Bellinger; Elena Colicino; Brent A Coull; Allan C Just; Itai Kloog; Erika Osorio-Valencia; Lourdes Schnaas; Rosalind J Wright; Martha M Téllez-Rojo; Robert O Wright; Megan K Horton Journal: Neurotoxicology Date: 2020-09-17 Impact factor: 4.398