Literature DB >> 278640

Effect of alpha-tocopherol on the cardiotoxicity of adriamycin in the rat.

P Sonneveld.   

Abstract

Adriamycin (ADR)-induced cardiomyopathy was studied in a rat model by means of electrocardiograms (ECGs), light microscopy, and determination of heart weight. Pretreatment with D-alpha-tocopherol (alpha-T) 24 hours prior to a high dose of ADR diminishes cardiotoxic effects, as judged by ECG changes, decreases in heart weight, and histologic changes. The response of an acute myeloid leukemia in a rat model to ADR was not affected by this pretreatment. The results provide evidence that alpha-T might be used to improve the therapeutic index of ADR.

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Year:  1978        PMID： 278640

Source DB:  PubMed          Journal:  Cancer Treat Rep        ISSN： 0361-5960


  11 in total

1.  Pretreatment with ICRF-187 provides long-lasting protection against chronic daunorubicin cardiotoxicity in rabbits.

Authors:  E H Herman; V J Ferrans
Journal:  Cancer Chemother Pharmacol       Date:  1986       Impact factor: 3.333

2.  A method for detection of doxorubicin-induced cardiotoxicity: Flow-mediated vasodilation of the brachial artery.

Authors:  L Nagy; F Szabó; J Iványi; L Németh; G L Kovács; J Palatka; J Tarján; K Tóth; E Roth
Journal:  Exp Clin Cardiol       Date:  2001

3.  Microsomal lipid peroxidation induced by adriamycin, epirubicin, daunorubicin and mitoxantrone: a comparative study.

Authors:  G F Vile; C C Winterbourn
Journal:  Cancer Chemother Pharmacol       Date:  1989       Impact factor: 3.333

Review 4.  Anthracycline antitumour agents. A review of physicochemical, analytical and stability properties.

Authors:  J Bouma; J H Beijnen; A Bult; W J Underberg
Journal:  Pharm Weekbl Sci       Date:  1986-04-25

Review 5.  Therapeutic modulation of free radical-mediated reperfusion injury of the liver and its surgical implications.

Authors:  S Marubayashi; K Dohi
Journal:  Surg Today       Date:  1996       Impact factor: 2.549

6.  Prevention of adriamycin toxicity.

Authors:  A R Banks; T Jones; T H Koch; R D Friedman; N R Bachur
Journal:  Cancer Chemother Pharmacol       Date:  1983       Impact factor: 3.333

7.  Cardiac disease induced by chronic adriamycin administration in dogs and an evaluation of vitamin E and selenium as cardioprotectants.

Authors:  J F Van Vleet; V J Ferrans; W E Weirich
Journal:  Am J Pathol       Date:  1980-04       Impact factor: 4.307

8.  Enzymatic defenses of the mouse heart against reactive oxygen metabolites: alterations produced by doxorubicin.

Authors:  J H Doroshow; G Y Locker; C E Myers
Journal:  J Clin Invest       Date:  1980-01       Impact factor: 14.808

9.  Prevention of doxorubicin cardiac toxicity in the mouse by N-acetylcysteine.

Authors:  J H Doroshow; G Y Locker; I Ifrim; C E Myers
Journal:  J Clin Invest       Date:  1981-10       Impact factor: 14.808

10.  Doxorubicin-induced cardiotoxicity in adult Indian patients on chemotherapy.

Authors:  Navin Khattry; Pankaj Malhotra; Anil Grover; Suresh C Sharma; Subhash Varma
Journal:  Indian J Med Paediatr Oncol       Date:  2009-01
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