Literature DB >> 27857978

WRNIP1: A new guardian of genome integrity at stalled replication forks.

Giuseppe Leuzzi1, Veronica Marabitti1, Pietro Pichierri2, Annapaola Franchitto1.   

Abstract

Failure to protect and/or restart stalled replication forks contributes to genomic instability. Radiation-sensitive 51 (RAD51) recombinase defends stalled forks from nucleolytic attack, which otherwise can threaten their integrity. Recently, we have uncovered a novel and key function of Werner helicase interacting protein 1 (WRNIP1) as a fork-protective factor working in conjunction with RAD51 in response to replication stress.

Entities:  

Keywords:  Genome instability; WRNIP1; replication fork stalling; replication stress

Year:  2016        PMID： 27857978      PMCID： PMC5068177          DOI： 10.1080/23723556.2016.1215777

Source DB:  PubMed          Journal:  Mol Cell Oncol        ISSN： 2372-3556


  10 in total

1.  Mre11-dependent degradation of stalled DNA replication forks is prevented by BRCA2 and PARP1.

Authors:  Songmin Ying; Freddie C Hamdy; Thomas Helleday
Journal:  Cancer Res       Date:  2012-03-23       Impact factor: 12.701

2.  WRNIP1 protects stalled forks from degradation and promotes fork restart after replication stress.

Authors:  Giuseppe Leuzzi; Veronica Marabitti; Pietro Pichierri; Annapaola Franchitto
Journal:  EMBO J       Date:  2016-05-30       Impact factor: 11.598

3.  Double-strand break repair-independent role for BRCA2 in blocking stalled replication fork degradation by MRE11.

Authors:  Katharina Schlacher; Nicole Christ; Nicolas Siaud; Akinori Egashira; Hong Wu; Maria Jasin
Journal:  Cell       Date:  2011-05-13       Impact factor: 41.582

4.  A global map of human gene expression.

Authors:  Margus Lukk; Misha Kapushesky; Janne Nikkilä; Helen Parkinson; Angela Goncalves; Wolfgang Huber; Esko Ukkonen; Alvis Brazma
Journal:  Nat Biotechnol       Date:  2010-04       Impact factor: 54.908

5.  Human Werner helicase interacting protein 1 (WRNIP1) functions as a novel modulator for DNA polymerase delta.

Authors:  Toshiki Tsurimoto; Ayako Shinozaki; Masaki Yano; Masayuki Seki; Takemi Enomoto
Journal:  Genes Cells       Date:  2005-01       Impact factor: 1.891

Review 6.  Causes and consequences of replication stress.

Authors:  Michelle K Zeman; Karlene A Cimprich
Journal:  Nat Cell Biol       Date:  2014-01       Impact factor: 28.824

7.  Human Wrnip1 is localized in replication factories in a ubiquitin-binding zinc finger-dependent manner.

Authors:  Nicola Crosetto; Marzena Bienko; Richard G Hibbert; Tina Perica; Chiara Ambrogio; Tobias Kensche; Kay Hofmann; Titia K Sixma; Ivan Dikic
Journal:  J Biol Chem       Date:  2008-10-07       Impact factor: 5.157

8.  Physical and functional interaction between WRNIP1 and RAD18.

Authors:  Akari Yoshimura; Masayuki Seki; Makoto Kanamori; Satoshi Tateishi; Toshiki Tsurimoto; Shusuke Tada; Takemi Enomoto
Journal:  Genes Genet Syst       Date:  2009-04       Impact factor: 1.517

Review 9.  DNA replication stress: causes, resolution and disease.

Authors:  Abdelghani Mazouzi; Georgia Velimezi; Joanna I Loizou
Journal:  Exp Cell Res       Date:  2014-09-30       Impact factor: 3.905

10.  Rad51 protects nascent DNA from Mre11-dependent degradation and promotes continuous DNA synthesis.

Authors:  Yoshitami Hashimoto; Arnab Ray Chaudhuri; Massimo Lopes; Vincenzo Costanzo
Journal:  Nat Struct Mol Biol       Date:  2010-10-10       Impact factor: 15.369
  10 in total
  1 in total

1.  Banp regulates DNA damage response and chromosome segregation during the cell cycle in zebrafish retina.

Authors:  Swathy Babu; Yuki Takeuchi; Ichiro Masai
Journal:  Elife       Date:  2022-08-09       Impact factor: 8.713
  1 in total

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