Daniele Andreini1, Gianluca Pontone2, Jan Bogaert3, Alberto Roghi4, Andrea Barison4, Juerg Schwitter5, Saima Mushtaq2, Georgios Vovas3, Paola Sormani4, Giovanni D Aquaro6, Pierre Monney5, Chiara Segurini2, Marco Guglielmo2, Edoardo Conte2, Laura Fusini2, Antonio Dello Russo2, Massimo Lombardi7, Paola Gripari2, Andrea Baggiano2, Cesare Fiorentini8, Federico Lombardi9, Antonio L Bartorelli10, Mauro Pepi2, Pier Giorgio Masci5. 1. Centro Cardiologico Monzino, IRCCS, Milan, Italy; Department of Clinical Sciences and Community Health, Cardiovascular Section, University of Milan, Milan, Italy. Electronic address: daniele.andreini@ccfm.it. 2. Centro Cardiologico Monzino, IRCCS, Milan, Italy. 3. Gasthuisberg University Hospital, Leuven, Belgium. 4. Niguarda Cà Granda Hospital, Milan, Italy. 5. Centre for Cardiac MR, Cardiology Department, University Hospital Lausanne, Lausanne, Switzerland. 6. Fondazione CNR-Regione Toscana 'G.Monasterio,' Pisa, Italy. 7. Multimodality Cardiac Imaging Section, Policlinico San Donato, Milan, Italy. 8. Centro Cardiologico Monzino, IRCCS, Milan, Italy; Department of Clinical Sciences and Community Health, Cardiovascular Section, University of Milan, Milan, Italy. 9. Department of Clinical Sciences and Community Health, Cardiovascular Section, University of Milan, Milan, Italy; Department of Cardiovascular Disease, Ospedale Maggiore Policlinico, Milan, Italy. 10. Centro Cardiologico Monzino, IRCCS, Milan, Italy; Department of Biomedical and Clinical Sciences "Luigi Sacco," University of Milan, Milan, Italy.
Abstract
BACKGROUND: Cardiac magnetic resonance (CMR) is useful for the diagnosis of left ventricular noncompaction (LVNC). However, there are limited data regarding its prognostic value. OBJECTIVES: The goal of this study was to evaluate the prognostic relevance of CMR findings in patients with LVNC. METHODS: A total of 113 patients with an echocardiographic diagnosis of LVNC underwent CMR at 5 referral centers. CMR diagnostic criterion of LVNC (noncompacted/compacted ratio >2.3 in end-diastole) was confirmed in all patients. We performed left ventricular (LV) and right ventricular quantitative analysis and late gadolinium enhancement (LGE) assessments and analyzed the following LVNC diagnostic criteria: left ventricular noncompacted myocardial mass (LV-ncMM) >20% and >25%, total LV-ncMM index >15 g/m2, noncompacted/compacted ratio ≥3:1 ≥1 of segments 1 to 3 and 7 to 16 or ≥2:1 in at least 1 of segments 4 to 6 of the American Heart Association model. Outcome was a composite of thromboembolic events, heart failure hospitalizations, ventricular arrhythmias, and cardiac death. RESULTS: At a mean follow-up of 48 ± 24 months, cardiac events (CEs) occurred in 36 patients (16 heart failure hospitalizations, 10 ventricular arrhythmias, 5 cardiac deaths, and 5 thromboembolic events). LV dilation, impaired LV ejection fraction, and LV-ncMM >20% was significantly more frequent in patients with CEs. LV fibrosis was detected by using LGE in 11 cases. CMR predictors of CEs were LV dilation and LGE. LGE was associated with improved prediction of CEs, compared with clinical data and CMR functional parameters in all 3 models. No CEs occurred in patients without dilated cardiomyopathy and/or LGE. CONCLUSIONS: In patients with LVNC evaluated by using CMR, the degree of LV trabeculation seems to have no prognostic impact over and above LV dilation, LV systolic dysfunction, and presence of LGE.
BACKGROUND: Cardiac magnetic resonance (CMR) is useful for the diagnosis of left ventricular noncompaction (LVNC). However, there are limited data regarding its prognostic value. OBJECTIVES: The goal of this study was to evaluate the prognostic relevance of CMR findings in patients with LVNC. METHODS: A total of 113 patients with an echocardiographic diagnosis of LVNC underwent CMR at 5 referral centers. CMR diagnostic criterion of LVNC (noncompacted/compacted ratio >2.3 in end-diastole) was confirmed in all patients. We performed left ventricular (LV) and right ventricular quantitative analysis and late gadolinium enhancement (LGE) assessments and analyzed the following LVNC diagnostic criteria: left ventricular noncompacted myocardial mass (LV-ncMM) >20% and >25%, total LV-ncMM index >15 g/m2, noncompacted/compacted ratio ≥3:1 ≥1 of segments 1 to 3 and 7 to 16 or ≥2:1 in at least 1 of segments 4 to 6 of the American Heart Association model. Outcome was a composite of thromboembolic events, heart failure hospitalizations, ventricular arrhythmias, and cardiac death. RESULTS: At a mean follow-up of 48 ± 24 months, cardiac events (CEs) occurred in 36 patients (16 heart failure hospitalizations, 10 ventricular arrhythmias, 5 cardiac deaths, and 5 thromboembolic events). LV dilation, impaired LV ejection fraction, and LV-ncMM >20% was significantly more frequent in patients with CEs. LV fibrosis was detected by using LGE in 11 cases. CMR predictors of CEs were LV dilation and LGE. LGE was associated with improved prediction of CEs, compared with clinical data and CMR functional parameters in all 3 models. No CEs occurred in patients without dilated cardiomyopathy and/or LGE. CONCLUSIONS: In patients with LVNC evaluated by using CMR, the degree of LV trabeculation seems to have no prognostic impact over and above LV dilation, LV systolic dysfunction, and presence of LGE.
Authors: Francesco Negri; Antonio De Luca; Enrico Fabris; Renata Korcova; Carlo Cernetti; Chrysanthos Grigoratos; Giovanni Donato Aquaro; Gaetano Nucifora; Paolo G Camici; Gianfranco Sinagra Journal: Heart Fail Rev Date: 2019-05 Impact factor: 4.214
Authors: Karol Miszalski-Jamka; John L Jefferies; Wojciech Mazur; Jan Głowacki; Jianhong Hu; Monika Lazar; Richard A Gibbs; Jacek Liczko; Jan Kłyś; Eric Venner; Donna M Muzny; Jarosław Rycaj; Jacek Białkowski; Ewa Kluczewska; Zbigniew Kalarus; Shalini Jhangiani; Hussein Al-Khalidi; Tomasz Kukulski; James R Lupski; William J Craigen; Matthew N Bainbridge Journal: Circ Cardiovasc Genet Date: 2017-08
Authors: Anna Reka Kiss; Zsófia Gregor; Adam Furak; Attila Tóth; Márton Horváth; Liliana Szabo; Csilla Czimbalmos; Zsofia Dohy; Bela Merkely; Hajnalka Vago; Andrea Szucs Journal: Anatol J Cardiol Date: 2021-08 Impact factor: 1.596