Literature DB >> 2784784

Molecular characterization of MHC class II antigens (beta 1 domain) in the BB diabetes-prone and -resistant rat.

N J Chao1, L Timmerman, H O McDevitt, C O Jacob.   

Abstract

The BB or BB/Worcester (BB/W) rat is widely recognized as a model for human insulin-dependent diabetes mellitus (IDDM). Of at least three genes implicated in genetic susceptibility to IDDM in this strain, one is clearly linked to the major histocompatibility complex (MHC). In an attempt to define the diabetogenic gene(s) linked to the MHC of the BB rat, cDNA clones encoding the class II MHC gene products of the BB diabetes-prone and diabetes-resistant sublines have been isolated and sequenced. For comparison, the beta 1 domain of class II genes of the Lewis rat (RT1L) were sequenced. Analysis of the sequence data reveals that the first domain of RT1.D beta and RT1.B beta chain of the BB rat are different from other rat or mouse class II sequences. However, these sequences were identical in both the BB diabetes-prone and BB diabetes-resistant sublines. The significance of these findings is discussed in relation to MHC class II sequence data in IDDM patients and in the nonobese diabetic (NOD) mouse strain.

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Year:  1989        PMID： 2784784     DOI： 10.1007/bf00717906

Source DB:  PubMed          Journal:  Immunogenetics        ISSN： 0093-7711            Impact factor:   2.846


  19 in total

1.  A molecular basis for MHC class II--associated autoimmunity.

Authors:  J A Todd; H Acha-Orbea; J I Bell; N Chao; Z Fronek; C O Jacob; M McDermott; A A Sinha; L Timmerman; L Steinman
Journal:  Science       Date:  1988-05-20       Impact factor: 47.728

2.  The first external domain of the nonobese diabetic mouse class II I-A beta chain is unique.

Authors:  H Acha-Orbea; H O McDevitt
Journal:  Proc Natl Acad Sci U S A       Date:  1987-04       Impact factor: 11.205

3.  The spontaneously diabetic Wistar rat. Metabolic and morphologic studies.

Authors:  A F Nakhooda; A A Like; C I Chappel; F T Murray; E B Marliss
Journal:  Diabetes       Date:  1977-02       Impact factor: 9.461

4.  Autoantibodies to a 64-kilodalton islet cell protein precede the onset of spontaneous diabetes in the BB rat.

Authors:  S Baekkeskov; T Dyrberg; A Lernmark
Journal:  Science       Date:  1984-06-22       Impact factor: 47.728

5.  MHC polymorphism pre-dating speciation.

Authors:  F Figueroa; E Günther; J Klein
Journal:  Nature       Date:  1988-09-15       Impact factor: 49.962

6.  Three recessive loci required for insulin-dependent diabetes in nonobese diabetic mice.

Authors:  M Prochazka; E H Leiter; D V Serreze; D L Coleman
Journal:  Science       Date:  1987-07-17       Impact factor: 47.728

7.  Hyperinducibility of Ia antigen on astrocytes correlates with strain-specific susceptibility to experimental autoimmune encephalomyelitis.

Authors:  P T Massa; V ter Meulen; A Fontana
Journal:  Proc Natl Acad Sci U S A       Date:  1987-06       Impact factor: 11.205

8.  Genetics of the spontaneous diabetic syndrome. Interaction of MHC and non-MHC-associated factors.

Authors:  E Colle; R D Guttmann; A Fuks; T A Seemayer; G J Prud'homme
Journal:  Mol Biol Med       Date:  1986-02

9.  Breeding of a non-obese, diabetic strain of mice.

Authors:  S Makino; K Kunimoto; Y Muraoka; Y Mizushima; K Katagiri; Y Tochino
Journal:  Jikken Dobutsu       Date:  1980-01

10.  Two genes required for diabetes in BB rats. Evidence from cyclical intercrosses and backcrosses.

Authors:  R A Jackson; J B Buse; R Rifai; D Pelletier; E L Milford; C B Carpenter; G S Eisenbarth; R M Williams
Journal:  J Exp Med       Date:  1984-06-01       Impact factor: 14.307
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  11 in total

Review 1.  Genetic analysis of susceptibility to type 1 diabetes.

Authors:  J A Todd
Journal:  Springer Semin Immunopathol       Date:  1992

2.  Polymorphism of the class II gene of rat major histocompatibility complex, RT1: partial sequence comparison of the first domain of the RT1.B beta 1 alleles.

Authors:  H Fujii; M Kakinuma; T Yoshiki; T Natori
Journal:  Immunogenetics       Date:  1991       Impact factor: 2.846

3.  Open reading frame sequencing and structure-based alignment of polypeptides encoded by RT1-Bb, RT1-Ba, RT1-Db, and RT1-Da alleles.

Authors:  Ruth A Ettinger; Antonis K Moustakas; Suzanne D Lobaton
Journal:  Immunogenetics       Date:  2004-10-23       Impact factor: 2.846

4.  Differential effects of oral versus intrathymic administration of polymorphic major histocompatibility complex class II peptides on mononuclear and endothelial cell activation and cytokine expression during a delayed-type hypersensitivity response.

Authors:  W W Hancock; S J Khoury; C B Carpenter; M H Sayegh
Journal:  Am J Pathol       Date:  1994-06       Impact factor: 4.307

5.  Microarray studies on effects of Pneumocystis carinii infection on global gene expression in alveolar macrophages.

Authors:  Bi-Hua Cheng; Yunlong Liu; Xiaoling Xuei; Chung-Ping Liao; Debao Lu; Mark E Lasbury; Pamela J Durant; Chao-Hung Lee
Journal:  BMC Microbiol       Date:  2010-04-08       Impact factor: 3.605

6.  The paradox of MHC-DRB exon/intron evolution: alpha-helix and beta-sheet encoding regions diverge while hypervariable intronic simple repeats coevolve with beta-sheet codons.

Authors:  F W Schwaiger; E Weyers; C Epplen; J Brün; G Ruff; A Crawford; J T Epplen
Journal:  J Mol Evol       Date:  1993-09       Impact factor: 2.395

7.  Complementary DNA sequences encoding the rat MHC class II RT1-Bu and RT1-Du alpha and beta chains.

Authors:  Alistair J Easterfield; J Andrew Bradley; Eleanor M Bolton
Journal:  Immunogenetics       Date:  2003-07-18       Impact factor: 2.846

8.  Induction of immunity and oral tolerance with polymorphic class II major histocompatibility complex allopeptides in the rat.

Authors:  M H Sayegh; S J Khoury; W W Hancock; H L Weiner; C B Carpenter
Journal:  Proc Natl Acad Sci U S A       Date:  1992-08-15       Impact factor: 11.205

9.  Rejection of skin allografts by indirect allorecognition of donor class I major histocompatibility complex peptides.

Authors:  J Fangmann; R Dalchau; J W Fabre
Journal:  J Exp Med       Date:  1992-06-01       Impact factor: 14.307

10.  Human HLA-DR beta gene hypervariable region homology in the biobreeding BB rat: selection of the diabetic-resistant subline as a rheumatoid arthritis research tool to characterize the immunopathologic response to human type II collagen.

Authors:  W C Watson; J P Thompson; K Terato; M A Cremer; A H Kang
Journal:  J Exp Med       Date:  1990-11-01       Impact factor: 14.307
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