Literature DB >> 6374896

Autoantibodies to a 64-kilodalton islet cell protein precede the onset of spontaneous diabetes in the BB rat.

S Baekkeskov, T Dyrberg, A Lernmark.   

Abstract

Spontaneous insulin-dependent diabetes mellitus (IDDM) in the BB rat is associated with the presence of antibodies to a 64-kilodalton rat islet cell protein. These protein antibodies appeared in young animals and remained for as long as 8 weeks before the clinical onset of IDDM. Antibodies to a 64-kilodalton human islet cell protein were found to be associated with human IDDM. Detection of the antibodies may therefore be used to predict an early immune reaction against pancreatic B cells.

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Year:  1984        PMID： 6374896     DOI： 10.1126/science.6374896

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  35 in total

1.  Autoantibodies to IA-2 not detected in NOD mice or BB rats.

Authors:  M G DeSilva; H S Jun; J W Yoon; A L Notkins; M S Lan
Journal:  Diabetologia       Date:  1996-10       Impact factor: 10.122

2.  Molecular characterization of MHC class II antigens (beta 1 domain) in the BB diabetes-prone and -resistant rat.

Authors:  N J Chao; L Timmerman; H O McDevitt; C O Jacob
Journal:  Immunogenetics       Date:  1989       Impact factor: 2.846

Review 3.  The epidemiology of diabetes in childhood with special reference to the Orient: implications for mechanism of beta cell damage.

Authors:  A L Drash; N Cho; N Tajima; M Rewers; R Laporte
Journal:  Indian J Pediatr       Date:  1989 Nov-Dec       Impact factor: 1.967

4.  A beta-cell glycoprotein of Mr 40 000 is the major rat islet cell immunogen following xenogenic immunisation.

Authors:  S Baekkeskov; A Lernmark
Journal:  Diabetologia       Date:  1984-07       Impact factor: 10.122

5.  Characterization of monoclonal islet cell reactive autoantibodies from the diabetic biobreeding (BB/OK) rat.

Authors:  B Ziegler; S Witt; K D Kohnert; M Schlosser; P Augstein; D Michaelis; I Klöting; M Ziegler
Journal:  Acta Diabetol       Date:  1993       Impact factor: 4.280

6.  Glutamate decarboxylase-, insulin-, and islet cell-antibodies and HLA typing to detect diabetes in a general population-based study of Swedish children.

Authors:  W A Hagopian; C B Sanjeevi; I Kockum; M Landin-Olsson; A E Karlsen; G Sundkvist; G Dahlquist; J Palmer; A Lernmark
Journal:  J Clin Invest       Date:  1995-04       Impact factor: 14.808

7.  Studies on autoimmunity for initiation of beta-cell destruction. VIII. Pancreatic beta-cell dependent autoantibody to a 38 kilodalton protein precedes the clinical onset of diabetes in BB rats.

Authors:  I Y Ko; S H Ihm; J W Yoon
Journal:  Diabetologia       Date:  1991-08       Impact factor: 10.122

Review 8.  The role of immunotherapy in type I diabetes mellitus.

Authors:  M E Geffner; B M Lippe
Journal:  West J Med       Date:  1987-03

9.  WIN 54954 treatment of mice infected with a diabetogenic strain of group B coxsackievirus.

Authors:  D M See; J G Tilles
Journal:  Antimicrob Agents Chemother       Date:  1993-08       Impact factor: 5.191

10.  Risk for developing type 1 (insulin-dependent) diabetes mellitus and the presence of islet 64K antibodies.

Authors:  H Bärmeier; D K McCulloch; J L Neifing; G Warnock; R V Rajotte; J P Palmer; A Lernmark
Journal:  Diabetologia       Date:  1991-10       Impact factor: 10.122
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