Literature DB >> 2784685

Closed-loop feedback control of propofol anaesthesia by quantitative EEG analysis in humans.

H Schwilden1, H Stoeckel, J Schüttler.   

Abstract

Propofol was administered for 2 h to 11 volunteers by an adaptive feedback control algorithm based on quantitative EEG analysis. Median EEG frequency served as the control variable. The range 2-3 Hz was chosen as the target range of control. During the feedback period, volunteers did not respond to commands and eyelash reflex was abolished. An average median frequency of 2.5 (SD 0.3) Hz was obtained by administering propofol 1452 (262) mg within 2 h. Time to recovery was 17.9 (8.0) min. Compared with a study with methohexitone using the same approach, the relative potency of propofol was 0.72. The mean recovery time was less than half that observed after methohexitone.

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Year:  1989        PMID： 2784685     DOI： 10.1093/bja/62.3.290

Source DB:  PubMed          Journal:  Br J Anaesth        ISSN： 0007-0912            Impact factor:   9.166


  13 in total

Review 1.  Electroencephalogram effect measures and relationships between pharmacokinetics and pharmacodynamics of centrally acting drugs.

Authors:  J W Mandema; M Danhof
Journal:  Clin Pharmacokinet       Date:  1992-09       Impact factor: 6.447

2.  A simulation-based comparative analysis of PID and LQG control for closed-loop anesthesia delivery.

Authors:  Sourish Chakravarty; Ayan S Waite; John H Abel; Emery N Brown
Journal:  Proc IFAC World Congress       Date:  2021-04-14

3.  A closed-loop anesthetic delivery system for real-time control of burst suppression.

Authors:  Max Y Liberman; Shinung Ching; Jessica Chemali; Emery N Brown
Journal:  J Neural Eng       Date:  2013-06-07       Impact factor: 5.379

4.  Robust control of burst suppression for medical coma.

Authors:  M Brandon Westover; Seong-Eun Kim; ShiNung Ching; Patrick L Purdon; Emery N Brown
Journal:  J Neural Eng       Date:  2015-05-28       Impact factor: 5.379

5.  Pharmacokinetics and pharmacodynamics of propofol/alfentanil infusions for sedation in ICU patients.

Authors:  C Frenkel; J Schuttler; H Ihmsen; H Heye; K Rommelsheim
Journal:  Intensive Care Med       Date:  1995-12       Impact factor: 17.440

6.  Real-time closed-loop control in a rodent model of medically induced coma using burst suppression.

Authors:  ShiNung Ching; Max Y Liberman; Jessica J Chemali; M Brandon Westover; Jonathan D Kenny; Ken Solt; Patrick L Purdon; Emery N Brown
Journal:  Anesthesiology       Date:  2013-10       Impact factor: 7.892

7.  Comparison of cognitive, ambulatory, and psychomotor recovery profiles after day care anesthesia with propofol and sevoflurane.

Authors:  Satyen Parida; Ashok Shankar Badhe
Journal:  J Anesth       Date:  2014-04-19       Impact factor: 2.078

8.  EEG bispectrum predicts movement during thiopental/isoflurane anesthesia.

Authors:  P S Sebel; S M Bowles; V Saini; N Chamoun
Journal:  J Clin Monit       Date:  1995-03

Review 9.  Excitatory events associated with propofol anaesthesia: a review.

Authors:  J R Sneyd
Journal:  J R Soc Med       Date:  1992-05       Impact factor: 18.000

10.  High-Precision Control of Plasma Drug Levels Using Feedback-Controlled Dosing.

Authors:  Netzahualcóyotl Arroyo-Currás; Gabriel Ortega; David A Copp; Kyle L Ploense; Zoe A Plaxco; Tod E Kippin; João P Hespanha; Kevin W Plaxco
Journal:  ACS Pharmacol Transl Sci       Date:  2018-10-05
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