Literature DB >> 31376405

ORMDL3 and allergic asthma: From physiology to pathology.

Briana James1, Sheldon Milstien1, Sarah Spiegel2.   

Abstract

There is a strong genetic component to asthma, and numerous genome-wide association studies have identified ORM1 (yeast)-like protein 3 (ORMDL3) as a gene associated with asthma susceptibility. However, how ORMDL3 contributes to asthma pathogenesis and its physiologic functions is not well understood and a matter of great debate. This rostrum describes recent advances and new insights in understanding of the multifaceted functions of ORMDL3 in patients with allergic asthma. We also suggest a potential unifying paradigm and discuss molecular mechanisms for the pathologic functions of ORMDL3 in asthma related to its evolutionarily conserved role in regulation of sphingolipid homeostasis. Finally, we briefly survey the utility of sphingolipid metabolites as potential biomarkers for allergic asthma.
Copyright © 2019 American Academy of Allergy, Asthma & Immunology. Published by Elsevier Inc. All rights reserved.

Entities:  

Keywords:  Asthma; ORM1 (yeast)–like protein 3; ceramide; endoplasmic reticulum stress; sphingolipids; unfolded protein response

Mesh：

Substances：

Year:  2019        PMID： 31376405      PMCID： PMC6910079          DOI： 10.1016/j.jaci.2019.07.023

Source DB:  PubMed          Journal:  J Allergy Clin Immunol        ISSN： 0091-6749            Impact factor:   10.793


  43 in total

1.  Impaired sphingolipid synthesis in the respiratory tract induces airway hyperreactivity.

Authors:  Tilla S Worgall; Arul Veerappan; Biin Sung; Benjamin I Kim; Evan Weiner; Reshma Bholah; Randi B Silver; Xian-Cheng Jiang; Stefan Worgall
Journal:  Sci Transl Med       Date:  2013-05-22       Impact factor: 17.956

2.  Alteration of ceramide synthase 6/C16-ceramide induces activating transcription factor 6-mediated endoplasmic reticulum (ER) stress and apoptosis via perturbation of cellular Ca2+ and ER/Golgi membrane network.

Authors:  Can E Senkal; Suriyan Ponnusamy; Yefim Manevich; Marisa Meyers-Needham; Sahar A Saddoughi; Archana Mukhopadyay; Paul Dent; Jacek Bielawski; Besim Ogretmen
Journal:  J Biol Chem       Date:  2011-10-19       Impact factor: 5.157

3.  A specific sphingosine kinase 1 inhibitor attenuates airway hyperresponsiveness and inflammation in a mast cell-dependent murine model of allergic asthma.

Authors:  Megan M Price; Carole A Oskeritzian; Yves T Falanga; Kuzhuvelil B Harikumar; Jeremy C Allegood; Sergio E Alvarez; Daniel Conrad; John J Ryan; Sheldon Milstien; Sarah Spiegel
Journal:  J Allergy Clin Immunol       Date:  2012-08-30       Impact factor: 10.793

4.  ORMDL/serine palmitoyltransferase stoichiometry determines effects of ORMDL3 expression on sphingolipid biosynthesis.

Authors:  Deanna Siow; Manjula Sunkara; Teresa M Dunn; Andrew J Morris; Binks Wattenberg
Journal:  J Lipid Res       Date:  2015-02-17       Impact factor: 5.922

5.  Myristate-induced endoplasmic reticulum stress requires ceramide synthases 5/6 and generation of C14-ceramide in intestinal epithelial cells.

Authors:  Songhwa Choi; Justin M Snider; Nicole Olakkengil; Johana M Lambert; Andrea K Anderson; Jessica S Ross-Evans; L Ashley Cowart; Ashley J Snider
Journal:  FASEB J       Date:  2018-05-16       Impact factor: 5.191

6.  Ceramide: a key signaling molecule in a Guinea pig model of allergic asthmatic response and airway inflammation.

Authors:  Emanuela Masini; Lucia Giannini; Silvia Nistri; Lorenzo Cinci; Rosanna Mastroianni; Wei Xu; Suzy A A Comhair; Dechun Li; Salvatore Cuzzocrea; George M Matuschak; Daniela Salvemini
Journal:  J Pharmacol Exp Ther       Date:  2007-11-27       Impact factor: 4.030

7.  The ORMDL3 Asthma Gene Regulates ICAM1 and Has Multiple Effects on Cellular Inflammation.

Authors:  Youming Zhang; Saffron A G Willis-Owen; Sarah Spiegel; Clare M Lloyd; Miriam F Moffatt; William O C M Cookson
Journal:  Am J Respir Crit Care Med       Date:  2019-02-15       Impact factor: 21.405

8.  Staurosporines decrease ORMDL proteins and enhance sphingomyelin synthesis resulting in depletion of plasmalemmal phosphatidylserine.

Authors:  Masashi Maekawa; Minhyoung Lee; Kuiru Wei; Neale D Ridgway; Gregory D Fairn
Journal:  Sci Rep       Date:  2016-11-02       Impact factor: 4.379

9.  Role of local CpG DNA methylation in mediating the 17q21 asthma susceptibility gasdermin B (GSDMB)/ORMDL sphingolipid biosynthesis regulator 3 (ORMDL3) expression quantitative trait locus.

Authors:  Parul H Kothari; Weiliang Qiu; Damien C Croteau-Chonka; Fernando D Martinez; Andrew H Liu; Robert F Lemanske; Carole Ober; Jerry A Krishnan; Dan L Nicolae; Kathleen C Barnes; Stephanie J London; Albino Barraza-Villarreal; Steven R White; Edward T Naureckas; Joshua Millstein; W James Gauderman; Frank D Gilliland; Vincent J Carey; Scott T Weiss; Benjamin A Raby
Journal:  J Allergy Clin Immunol       Date:  2018-01-31       Impact factor: 10.793

10.  Metabolomics analysis identifies different metabotypes of asthma severity.

Authors:  Stacey N Reinke; Héctor Gallart-Ayala; Cristina Gómez; Antonio Checa; Alexander Fauland; Shama Naz; Muhammad Anas Kamleh; Ratko Djukanović; Timothy S C Hinks; Craig E Wheelock
Journal:  Eur Respir J       Date:  2017-03-29       Impact factor: 33.795
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  19 in total

Review 1.  Update on the role of endoplasmic reticulum stress in asthma.

Authors:  Kang Miao; Lei Zhang; Ting Pan; Yi Wang
Journal:  Am J Transl Res       Date:  2020-04-15       Impact factor: 4.060

2.  Sphingolipids and Asthma.

Authors:  Tilla S Worgall
Journal:  Adv Exp Med Biol       Date:  2022       Impact factor: 2.622

3.  Single-cell RNA-seq reveals cell type-specific molecular and genetic associations to lupus.

Authors:  Richard K Perez; M Grace Gordon; Meena Subramaniam; Min Cheol Kim; George C Hartoularos; Sasha Targ; Yang Sun; Anton Ogorodnikov; Raymund Bueno; Andrew Lu; Mike Thompson; Nadav Rappoport; Andrew Dahl; Cristina M Lanata; Mehrdad Matloubian; Lenka Maliskova; Serena S Kwek; Tony Li; Michal Slyper; Julia Waldman; Danielle Dionne; Orit Rozenblatt-Rosen; Lawrence Fong; Maria Dall'Era; Brunilda Balliu; Aviv Regev; Jinoos Yazdany; Lindsey A Criswell; Noah Zaitlen; Chun Jimmie Ye
Journal:  Science       Date:  2022-04-08       Impact factor: 63.714

4.  Integrative multiomics analysis highlights immune-cell regulatory mechanisms and shared genetic architecture for 14 immune-associated diseases and cancer outcomes.

Authors:  Claire Prince; Ruth E Mitchell; Tom G Richardson
Journal:  Am J Hum Genet       Date:  2021-11-05       Impact factor: 11.043

5.  Untargeted metabolomic profiling identifies disease-specific signatures in food allergy and asthma.

Authors:  Elena Crestani; Hani Harb; Louis-Marie Charbonnier; Jonathan Leirer; Alison Motsinger-Reif; Rima Rachid; Wanda Phipatanakul; Rima Kaddurah-Daouk; Talal A Chatila
Journal:  J Allergy Clin Immunol       Date:  2019-10-25       Impact factor: 10.793

Review 6.  The airway epithelium during infancy and childhood: A complex multicellular immune barrier. Basic review for clinicians.

Authors:  Xilei Xu-Chen; Jered Weinstock; Deepa Rastogi; Anastassios Koumbourlis; Gustavo Nino
Journal:  Paediatr Respir Rev       Date:  2021-04-22       Impact factor: 2.726

7.  Solving the Riddle: Targeting the Imbalance of Sphingolipids in Asthma to Oppose Airway Hyperresponsiveness.

Authors:  Maggie Lam; Jane E Bourke
Journal:  Am J Respir Cell Mol Biol       Date:  2020-11       Impact factor: 6.914

8.  Increased expression of serine palmitoyl transferase and ORMDL3 polymorphism are associated with eosinophilic inflammation and airflow limitation in aspirin-exacerbated respiratory disease.

Authors:  Ga-Young Ban; Dong-Ye Youn; Young-Min Ye; Hae-Sim Park
Journal:  PLoS One       Date:  2020-10-08       Impact factor: 3.240

Review 9.  Biomarkers in Different Asthma Phenotypes.

Authors:  Sanja Popović-Grle; Anamarija Štajduhar; Marina Lampalo; Dina Rnjak
Journal:  Genes (Basel)       Date:  2021-05-25       Impact factor: 4.096

Review 10.  Endoplasmic reticulum stress and glutathione therapeutics in chronic lung diseases.

Authors:  Yvonne Janssen-Heininger; Niki L Reynaert; Albert van der Vliet; Vikas Anathy
Journal:  Redox Biol       Date:  2020-03-23       Impact factor: 11.799
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