Toshiko Tanaka1, Ambarish Dutta2, Luke C Pilling3, Luting Xue4, Kathryn L Lunetta5,4, Joanne M Murabito5,6, Stefania Bandinelli7, Robert Wallace8, David Melzer3, Luigi Ferrucci1. 1. Translational Gerontology Branch, National Institute on Aging, Baltimore, Maryland. 2. Public Health Foundation of India, Bhubaneswar, Odisha,India. 3. Epidemiology and Public Health Group, University of Exeter Medical School, UK. 4. Department of Biostatistics, Boston University School of Public Health, Massachusetts. 5. National Heart, Lung and Blood Institute's and Boston University's Framingham Heart Study, Massachusetts. 6. Section of General Internal Medicine, Department of Medicine, Boston University School of Medicine, Massachusetts. 7. Geriatric Unit, Azienda Sanitaria Firenze (ASF), Florence, Italy. 8. Department of Epidemiology, University of Iowa College of Public Health.
Abstract
BACKGROUND: Having longer lived parents has been shown to be an important predictor of health trajectories and life span. As such, parental life span is an important phenotype that may uncover genes that affect longevity. METHODS: A genome-wide association study of parental life span in participants of European and African ancestry from the Health and Retirement Study was conducted. RESULTS: A genome-wide significant association was observed for rs35715456 (log10BF = 6.3) on chromosome 18 for the dichotomous trait of having at least one long-lived parent versus not having any long-lived parent. This association was not replicated in an independent sample from the InCHIANTI and Framingham Heart Study. The most significant association among single nucleotide polymorphisms in longevity candidate genes (APOE, MINIPP1, FOXO3, EBF1, CAMKIV, and OTOL1) was observed in the EBF1 gene region (rs17056207, p = .0002). CONCLUSIONS: A promising genetic signal for parental life span was identified but was not replicated in independent samples. Published by Oxford University Press on behalf of The Gerontological Society of America 2016. This work is written by (a) US Government employee(s) and is in the public domain in the US.
BACKGROUND: Having longer lived parents has been shown to be an important predictor of health trajectories and life span. As such, parental life span is an important phenotype that may uncover genes that affect longevity. METHODS: A genome-wide association study of parental life span in participants of European and African ancestry from the Health and Retirement Study was conducted. RESULTS: A genome-wide significant association was observed for rs35715456 (log10BF = 6.3) on chromosome 18 for the dichotomous trait of having at least one long-lived parent versus not having any long-lived parent. This association was not replicated in an independent sample from the InCHIANTI and Framingham Heart Study. The most significant association among single nucleotide polymorphisms in longevity candidate genes (APOE, MINIPP1, FOXO3, EBF1, CAMKIV, and OTOL1) was observed in the EBF1 gene region (rs17056207, p = .0002). CONCLUSIONS: A promising genetic signal for parental life span was identified but was not replicated in independent samples. Published by Oxford University Press on behalf of The Gerontological Society of America 2016. This work is written by (a) US Government employee(s) and is in the public domain in the US.
Entities:
Keywords:
Epidemiology; Genetics; Life span; Public health; Successful aging
Authors: Paola Sebastiani; Lisa Nussbaum; Stacy L Andersen; Mara J Black; Thomas T Perls Journal: J Gerontol A Biol Sci Med Sci Date: 2015-03-26 Impact factor: 6.053
Authors: Amanda Sonnega; Jessica D Faul; Mary Beth Ofstedal; Kenneth M Langa; John W R Phillips; David R Weir Journal: Int J Epidemiol Date: 2014-03-25 Impact factor: 7.196
Authors: Dellara F Terry; Jane C Evans; Michael J Pencina; Joanne M Murabito; Ramachandran S Vasan; Philip A Wolf; Margaret Kelly-Hayes; Daniel Levy; Ralph B D'Agostino; Emelia J Benjamin Journal: Arch Intern Med Date: 2007-03-12
Authors: Ambarish Dutta; William Henley; Jean-Marie Robine; David Llewellyn; Kenneth M Langa; Robert B Wallace; David Melzer Journal: Alzheimers Dement Date: 2013-11-06 Impact factor: 21.566
Authors: Emily R Adams; Vikki G Nolan; Stacy L Andersen; Thomas T Perls; Dellara F Terry Journal: J Am Geriatr Soc Date: 2008-09-22 Impact factor: 5.562
Authors: Bradley J Willcox; Timothy A Donlon; Qimei He; Randi Chen; John S Grove; Katsuhiko Yano; Kamal H Masaki; D Craig Willcox; Beatriz Rodriguez; J David Curb Journal: Proc Natl Acad Sci U S A Date: 2008-09-02 Impact factor: 11.205