Ambarish Dutta1, William Henley2, Jean-Marie Robine3, David Llewellyn1, Kenneth M Langa4, Robert B Wallace5, David Melzer6. 1. Epidemiology and Public Health Group, Medical School, University of Exeter, Exeter, UK. 2. PenCLAHRC, Medical School, University of Exeter, Exeter, UK. 3. Institut National de la Sante et de la Recherche Medicale, U710 and U988, Paris and Montpellier, France. 4. Division of General Medicine, University of Michigan Health System, Ann Arbor, MI, USA; VA Ann Arbor Center for Clinical Management Research, Ann Arbor, MI, USA. 5. Center on Aging, Department of Epidemiology, College of Public Health, The University of Iowa, Iowa City, IA, USA. 6. Epidemiology and Public Health Group, Medical School, University of Exeter, Exeter, UK. Electronic address: D.Melzer@exeter.ac.uk.
Abstract
BACKGROUND: Parental longevity confers lower risks for some age-related diseases in offspring. We tested the association between parental longevity and late-life cognitive decline or dementia. METHODS: Data were from the Health and Retirement Study (HRS), a US national sample. Biennial cognitive assessment (Telephone Interview of Cognitive Status-Modified [TICS-m]) occurred for ages 64 years or older in 1996 through 2008 (maximum, 79 years), including physician-diagnosed memory disorder. Offspring were categorized into parental longevity groups based on gender-specific distributional cut points. Model covariates included race, respondents' education, and income status during childhood and adulthood. RESULTS: Offspring groups did not differ on TICS-m scores at baseline. During follow-up, offspring of two long-lived parents experienced 40% slower rates of TICS-m decline than those with no long-lived parents (95% confidence interval, 12-72; P=.003; n=4731). Increased parental longevity was also associated with lower risk of physician-diagnosed memory disorder. Estimates did not change after controlling for environmental variables. CONCLUSIONS: Parental longevity is associated inversely with cognitive decline and self-reported diagnosed memory disorders in aging offspring. Parental longevity may be a valuable trait for identifying early biomarkers for resistance to cognitive decline in aging.
BACKGROUND: Parental longevity confers lower risks for some age-related diseases in offspring. We tested the association between parental longevity and late-life cognitive decline or dementia. METHODS: Data were from the Health and Retirement Study (HRS), a US national sample. Biennial cognitive assessment (Telephone Interview of Cognitive Status-Modified [TICS-m]) occurred for ages 64 years or older in 1996 through 2008 (maximum, 79 years), including physician-diagnosed memory disorder. Offspring were categorized into parental longevity groups based on gender-specific distributional cut points. Model covariates included race, respondents' education, and income status during childhood and adulthood. RESULTS: Offspring groups did not differ on TICS-m scores at baseline. During follow-up, offspring of two long-lived parents experienced 40% slower rates of TICS-m decline than those with no long-lived parents (95% confidence interval, 12-72; P=.003; n=4731). Increased parental longevity was also associated with lower risk of physician-diagnosed memory disorder. Estimates did not change after controlling for environmental variables. CONCLUSIONS: Parental longevity is associated inversely with cognitive decline and self-reported diagnosed memory disorders in aging offspring. Parental longevity may be a valuable trait for identifying early biomarkers for resistance to cognitive decline in aging.
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