Literature DB >> 27815339

Should future interventional neuroradiologists be screened for mutations that impair radiation-induced DNA repair?

Kieran Murphy1, Adam Thakore2, Marie Constance Lacasse3, Danyal Z Khan4.   

Abstract

In our current medical practice, an increasing number of specialists now have access to radiology technical platforms in order to perform imaging-guided procedures. Although knowledge about the current guidelines and radiation protection devices is a pre-requisite for the use of radiation, the preventive measures are often more or less strictly followed, leading to chronic daily exposure to significant doses of radiation and large accumulated lifetime exposures. Aortic intervention, electrophysiology, and neuro intervention in particular can result in large doses to the operators. Interventionalists might try to rationalize their dismissal of the exposure risks with various excuses: they don't know where they left their badges (even though, guiltily, they would readily admit it is good practice to always wear them), the estimated short duration of the procedure, significant muscular strain and spasm caused by the heaviness of lead aprons, decreased dexterity with lead gloves, or discomfort in wearing lead protective glasses. But their dismissive attitude is most likely due to the inherent inability to feel threatened by something they cannot see or feel, a commitment to the patient at all cost, and a culture of bravado that reinforces their behavior.

Entities:  

Keywords:  Radiation injury; cancer risk; genetic screening

Mesh:

Year:  2016        PMID: 27815339      PMCID: PMC5305144          DOI: 10.1177/1591019916662380

Source DB:  PubMed          Journal:  Interv Neuroradiol        ISSN: 1591-0199            Impact factor:   1.610


  7 in total

Review 1.  The role of p53 in determining sensitivity to radiotherapy.

Authors:  Andrei V Gudkov; Elena A Komarova
Journal:  Nat Rev Cancer       Date:  2003-02       Impact factor: 60.716

2.  Cancer risk among staff at two radiotherapy departments in Denmark.

Authors:  M Andersson; G Engholm; K Ennow; K A Jessen; H H Storm
Journal:  Br J Radiol       Date:  1991-05       Impact factor: 3.039

3.  The 2007 Recommendations of the International Commission on Radiological Protection. ICRP publication 103.

Authors: 
Journal:  Ann ICRP       Date:  2007

Review 4.  Microscopic imaging of DNA repair foci in irradiated normal tissues.

Authors:  Nirmal Bhogal; Farid Jalali; Robert G Bristow
Journal:  Int J Radiat Biol       Date:  2009-09       Impact factor: 2.694

5.  Brain and neck tumors among physicians performing interventional procedures.

Authors:  Ariel Roguin; Jacob Goldstein; Olivier Bar; James A Goldstein
Journal:  Am J Cardiol       Date:  2013-02-16       Impact factor: 2.778

6.  Increased frequency of chromosome translocations in airline pilots with long-term flying experience.

Authors:  L C Yong; A J Sigurdson; E M Ward; M A Waters; E A Whelan; M R Petersen; P Bhatti; M J Ramsey; E Ron; J D Tucker
Journal:  Occup Environ Med       Date:  2008-12-11       Impact factor: 4.402

7.  First analysis of mortality and occupational radiation exposure based on the National Dose Registry of Canada.

Authors:  J P Ashmore; D Krewski; J M Zielinski; H Jiang; R Semenciw; P R Band
Journal:  Am J Epidemiol       Date:  1998-09-15       Impact factor: 4.897

  7 in total

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