Literature DB >> 27813452

Cognitive remediation to enhance mobility in older adults: the CREM study.

Joe Verghese1,2, Emmeline Ayers1, Jeannette R Mahoney1, Anne Ambrose3, Cuiling Wang4, Roee Holtzer1,5.   

Abstract

Mobility disabilities represent the most prevalent disability among seniors. Emerging evidence indicates that executive functions play an important role in maintaining mobility. However, the use of cognitive remediation programs to enhance mobility has not been investigated in a full-scale randomized control trial. The CREM study is a single-blind randomized control trial to examine the effect of computerized cognitive remediation versus computer-based health education training on mobility in 420 seniors. The primary outcome is change in gait speed during normal walking and walking-while-talking conditions from baseline to postintervention. Secondary outcomes are change in mobility, mobility-related cognitive processes and neuroplasticity. Results of this study will fill an important gap in the efficacy and feasibility of cognitive remediation to improve mobility in seniors.

Entities:  

Keywords:  clinical trial protocol; cognitive remediation; executive function; gait velocity

Mesh:

Year:  2016        PMID: 27813452      PMCID: PMC5134757          DOI: 10.2217/nmt-2016-0034

Source DB:  PubMed          Journal:  Neurodegener Dis Manag        ISSN: 1758-2024


  53 in total

1.  Validity of divided attention tasks in predicting falls in older individuals: a preliminary study.

Authors:  Joe Verghese; Herman Buschke; Lisa Viola; Mindy Katz; Charles Hall; Gail Kuslansky; Richard Lipton
Journal:  J Am Geriatr Soc       Date:  2002-09       Impact factor: 5.562

2.  Effect of cognitive remediation on gait in sedentary seniors.

Authors:  Joe Verghese; Jeannette Mahoney; Anne F Ambrose; Cuiling Wang; Roee Holtzer
Journal:  J Gerontol A Biol Sci Med Sci       Date:  2010-07-19       Impact factor: 6.053

3.  Walking while talking: effect of task prioritization in the elderly.

Authors:  Joe Verghese; Gail Kuslansky; Roee Holtzer; Mindy Katz; Xiaonan Xue; Herman Buschke; Marco Pahor
Journal:  Arch Phys Med Rehabil       Date:  2007-01       Impact factor: 3.966

Review 4.  Indications, labeling, and outcomes assessment for drugs aimed at improving functional status in older persons: a conversation between aging researchers and FDA regulators.

Authors:  Shalender Bhasin; Mark A Espeland; William J Evans; Luigi Ferrucci; Linda P Fried; Thomas M Gill; Marco Pahor; Stephanie Studenski; Jack Guralnik; Susan Nayfield; Sergei Romashkin; Robert Perlstein; Laurie Burke; Mary Parks
Journal:  J Gerontol A Biol Sci Med Sci       Date:  2009-03-06       Impact factor: 6.053

5.  Benefits of cognitive dual-task training on balance performance in healthy older adults.

Authors:  Karen Z H Li; E Roudaia; M Lussier; L Bherer; A Leroux; P A McKinley
Journal:  J Gerontol A Biol Sci Med Sci       Date:  2010-09-13       Impact factor: 6.053

6.  Training-related changes in dual-task walking performance of elderly persons with balance impairment: a double-blind, randomized controlled trial.

Authors:  Patima Silsupadol; Vipul Lugade; Anne Shumway-Cook; Paul van Donkelaar; Li-Shan Chou; Ulrich Mayr; Marjorie H Woollacott
Journal:  Gait Posture       Date:  2009-02-07       Impact factor: 2.840

7.  A randomized controlled trial of rehabilitation after hospitalization in frail older women: effects on strength, balance and mobility.

Authors:  Leena Timonen; Taina Rantanen; Olli-Pekka Ryynänen; Simo Taimela; Tero E Timonen; Raimo Sulkava
Journal:  Scand J Med Sci Sports       Date:  2002-06       Impact factor: 4.221

8.  Impact of Cognitive Training on Balance and Gait in Older Adults.

Authors:  Renae L Smith-Ray; Susan L Hughes; Thomas R Prohaska; Deborah M Little; Donald A Jurivich; Donald Hedeker
Journal:  J Gerontol B Psychol Sci Soc Sci       Date:  2013-11-05       Impact factor: 4.077

Review 9.  Gait speed at usual pace as a predictor of adverse outcomes in community-dwelling older people an International Academy on Nutrition and Aging (IANA) Task Force.

Authors:  G Abellan van Kan; Y Rolland; S Andrieu; J Bauer; O Beauchet; M Bonnefoy; M Cesari; L M Donini; S Gillette Guyonnet; M Inzitari; F Nourhashemi; G Onder; P Ritz; A Salva; M Visser; B Vellas
Journal:  J Nutr Health Aging       Date:  2009-12       Impact factor: 4.075

10.  Mobility stress test approach to predicting frailty, disability, and mortality in high-functioning older adults.

Authors:  Joe Verghese; Roee Holtzer; Richard B Lipton; Cuiling Wang
Journal:  J Am Geriatr Soc       Date:  2012-09-24       Impact factor: 5.562

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  3 in total

1.  Cognitive-Based Interventions to Improve Mobility: A Systematic Review and Meta-analysis.

Authors:  Uros Marusic; Joe Verghese; Jeannette R Mahoney
Journal:  J Am Med Dir Assoc       Date:  2018-04-19       Impact factor: 4.669

2.  Does Cognitive Training Improve Mobility, Enhance Cognition, and Promote Neural Activation?

Authors:  Uros Marusic; Joe Verghese; Jeannette R Mahoney
Journal:  Front Aging Neurosci       Date:  2022-05-23       Impact factor: 5.702

3.  Computerised cognitive remediation to enhance mobility in older adults: a single-blind, single-centre, randomised trial.

Authors:  Joe Verghese; Jeannette R Mahoney; Emmeline Ayers; Anne Ambrose; Cuiling Wang; Roee Holtzer
Journal:  Lancet Healthy Longev       Date:  2021-09-02
  3 in total

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