Rakin Chowdhury1, Nancye M Peel2, Mitchell Krosch2, Ruth E Hubbard2. 1. Centre for Research in Geriatric Medicine, The University of Queensland, Brisbane, Queensland, Australia. Electronic address: rakin.chowdhury@uqconnect.edu.au. 2. Centre for Research in Geriatric Medicine, The University of Queensland, Brisbane, Queensland, Australia.
Abstract
OBJECTIVE: Frailty is associated with increased vulnerability to poor health. There is growing interest in understanding the association between frailty and chronic kidney disease (CKD). This systematic review explored how frailty is measured in patients with CKD and the association between frailty and adverse outcomes across different stages of renal impairment. STUDY DESIGN: Systematic analysis of peer reviewed articles. DATA SOURCES: Pubmed, Medline, Web of Science and Cochrane were used to identify the articles. DATA SYNTHESIS: Articles published before the 17th of September 2016, that measured frailty in patients with CKD was eligible for the systematic review. Two independent researchers assessed the eligibility of the articles. Quality of the articles was assessed using the Epidemiological Appraisal Instrument. RESULTS: The literature search yielded 540 articles, of which 32 met the study criteria and were included in the review (n=36,076, age range: 50-83 years). Twenty-three (72%) studies used or adapted the Fried phenotype to measure frailty. The prevalence of frailty ranged from 7% in community-dwellers (CKD Stages 1-4) to 73% in a cohort of patients on haemodialysis. The incidence of frailty increased with reduced glomerular filtration rate. Frailty was associated with an increased risk of mortality and hospitalization. CONCLUSION: Frailty is prevalent in patients with CKD and it is associated with an increased risk of adverse health outcomes. There are differences in the methods used to assess frailty and this hinders comparisons between studies. Crown Copyright Â
OBJECTIVE: Frailty is associated with increased vulnerability to poor health. There is growing interest in understanding the association between frailty and chronic kidney disease (CKD). This systematic review explored how frailty is measured in patients with CKD and the association between frailty and adverse outcomes across different stages of renal impairment. STUDY DESIGN: Systematic analysis of peer reviewed articles. DATA SOURCES: Pubmed, Medline, Web of Science and Cochrane were used to identify the articles. DATA SYNTHESIS: Articles published before the 17th of September 2016, that measured frailty in patients with CKD was eligible for the systematic review. Two independent researchers assessed the eligibility of the articles. Quality of the articles was assessed using the Epidemiological Appraisal Instrument. RESULTS: The literature search yielded 540 articles, of which 32 met the study criteria and were included in the review (n=36,076, age range: 50-83 years). Twenty-three (72%) studies used or adapted the Fried phenotype to measure frailty. The prevalence of frailty ranged from 7% in community-dwellers (CKD Stages 1-4) to 73% in a cohort of patients on haemodialysis. The incidence of frailty increased with reduced glomerular filtration rate. Frailty was associated with an increased risk of mortality and hospitalization. CONCLUSION: Frailty is prevalent in patients with CKD and it is associated with an increased risk of adverse health outcomes. There are differences in the methods used to assess frailty and this hinders comparisons between studies. Crown Copyright Â
Authors: Meera Nair Harhay; Karthik Ranganna; Suzanne M Boyle; Antonia M Brown; Thalia Bajakian; Lissa B Levin Mizrahi; Gary Xiao; Stephen Guy; Gregory Malat; Dorry L Segev; David Reich; Mara McAdams-DeMarco Journal: Am J Kidney Dis Date: 2019-05-21 Impact factor: 8.860
Authors: Mathew S Maurer; Evelyn Horn; Alex Reyentovich; Victoria Vaughan Dickson; Sean Pinney; Deena Goldwater; Nathan E Goldstein; Omar Jimenez; Sergio Teruya; Jeff Goldsmith; Stephen Helmke; Melana Yuzefpolskaya; Gordon R Reeves Journal: J Am Geriatr Soc Date: 2017-09-21 Impact factor: 5.562
Authors: Jonathan Myers; Khin N Chan; Yu Chen; Yiming Lit; Payam Massaband; B Jenny Kiratli; Jane C Tan; Ralph Rabkin Journal: Aging Clin Exp Res Date: 2021-03-08 Impact factor: 3.636
Authors: Elizabeth C Lorenz; LaTonya J Hickson; Renee M Weatherly; Karin L Thompson; Heidi A Walker; Judy M Rasmussen; Tara L Stewart; James K Garrett; Hatem Amer; Cassie C Kennedy Journal: Clin Transplant Date: 2020-07-24 Impact factor: 2.863
Authors: Nicolas A Baddour; Cassianne Robinson-Cohen; Loren Lipworth; Aihua Bian; Thomas G Stewart; Manisha Jhamb; Edward D Siew; Khaled Abdel-Kader Journal: J Palliat Med Date: 2019-06-28 Impact factor: 2.947
Authors: Meera N Harhay; Maya K Rao; Kenneth J Woodside; Kirsten L Johansen; Krista L Lentine; Stefan G Tullius; Ronald F Parsons; Tarek Alhamad; Joseph Berger; XingXing S Cheng; Jaqueline Lappin; Raymond Lynch; Sandesh Parajuli; Jane C Tan; Dorry L Segev; Bruce Kaplan; Jon Kobashigawa; Darshana M Dadhania; Mara A McAdams-DeMarco Journal: Nephrol Dial Transplant Date: 2020-07-01 Impact factor: 5.992
Authors: Aida Venado; Nicholas A Kolaitis; Chiung-Yu Huang; Ying Gao; David V Glidden; Allison Soong; Nicole Sutter; Patricia P Katz; John R Greenland; Daniel R Calabrese; Steven R Hays; Jeffrey A Golden; Rupal J Shah; Lorriana E Leard; Jasleen Kukreja; Tobias Deuse; Paul J Wolters; Kenneth Covinsky; Paul D Blanc; Jonathan P Singer Journal: Thorax Date: 2020-05-06 Impact factor: 9.139