Zhou Li1, Guanhua Deng2, Zhe Li3, Sherman Xuegang Xin3, Song Duan3, Maoying Lan3, Sa Zhang3, Yixin Gao4, Jun He5, Songtao Zhang5, Hongming Tang5, Weiwei Wang1, Shuai Han1, Qing X Yang6, Ling Zhuang7, Jiani Hu8, Feng Liu9. 1. Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, 510280, China. 2. Biomedical Engineering Department and Guangdong Provincial Key Laboratory of Medical Image Processing, Southern Medical University, Guangzhou, Guangdong, 510515, China and Department of Oncology, Guangdong 999 Brain Hospital, Guangzhou, Guangdong, 510510, China. 3. Biomedical Engineering Department and Guangdong Provincial Key Laboratory of Medical Image Processing, Southern Medical University, Guangzhou, Guangdong, 510515, China. 4. The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, 510080, China. 5. Shanghai Chenguang Medical Technologies Co., Ltd., Shanghai, 201707, China. 6. Center for NMR Research, Penn State College of Medicine, Hershey, Pennsylvania 17033. 7. Department of Oncology, School of Medicine, Wayne State University, Detroit, Michigan 48201. 8. Department of Radiology, Wayne State University School of Medicine, Detroit, Michigan 48201. 9. School of Information Technology and Electrical Engineering of Queensland University, Brisbane 4702, Australia.
Abstract
PURPOSE: Knowledge of dielectric properties of malignant human tissues is necessary for the recently developed magnetic resonance (MR) technique called MR electrical property tomography. This technique may be used in early tumor detection based on the obvious differentiation of the dielectric properties between normal and malignant tissues. However, the dielectric properties of malignant human tissues in the scale of the Larmor frequencies are not completely available in the literature. In this study, the authors focused only on the dielectric properties of colorectal tumor tissue. METHODS: The dielectric properties of 504 colorectal malignant samples excised from 85 patients in the scale of the Larmor frequencies were measured using the precision open-ended coaxial probe method. The obtained complex-permittivity data were fitted to the single-pole Cole-Cole model. RESULTS: The median permittivity and conductivity for the malignant tissue sample were 79.3 and 0.881 S/m at 128 MHz, which were 14.6% and 17.0% higher, respectively, than those of normal tissue samples. Significant differences between normal and malignant tissues were found for the dielectric properties (p < 0.05). CONCLUSIONS: Experimental results indicated that the dielectric properties were significantly different between normal and malignant tissues for colorectal tissue. This large-scale clinical measurement provides more subtle base data to validate the technique of MR electrical property tomography.
PURPOSE: Knowledge of dielectric properties of malignant human tissues is necessary for the recently developed magnetic resonance (MR) technique called MR electrical property tomography. This technique may be used in early tumor detection based on the obvious differentiation of the dielectric properties between normal and malignant tissues. However, the dielectric properties of malignant human tissues in the scale of the Larmor frequencies are not completely available in the literature. In this study, the authors focused only on the dielectric properties of colorectal tumor tissue. METHODS: The dielectric properties of 504 colorectal malignant samples excised from 85 patients in the scale of the Larmor frequencies were measured using the precision open-ended coaxial probe method. The obtained complex-permittivity data were fitted to the single-pole Cole-Cole model. RESULTS: The median permittivity and conductivity for the malignant tissue sample were 79.3 and 0.881 S/m at 128 MHz, which were 14.6% and 17.0% higher, respectively, than those of normal tissue samples. Significant differences between normal and malignant tissues were found for the dielectric properties (p < 0.05). CONCLUSIONS: Experimental results indicated that the dielectric properties were significantly different between normal and malignant tissues for colorectal tissue. This large-scale clinical measurement provides more subtle base data to validate the technique of MR electrical property tomography.