Ying Sun1, Hongfeng Yu1, Difu Zhou2, Xuegang Xin3, Di Lu4, Kaican Cai4, Xuefei Yu1. 1. School of Biomedical Engineering, Southern Medical University, Guangzhou 510515, China. 2. Department of Medical Equipment, Second Affiliated Hospital of Guangzhou Medical University, Guangzhou 510000, China. 3. School of Medicine, South China University of Technology, Guangzhou 510000, China. 4. Department of Thoracic Surgery, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
Abstract
OBJECTIVE: To investigate the differences in dielectric properties (relative dielectric constant and conductivity) between metastatic and non-metastatic lymph nodes (LNs). METHODS: An open-end coaxial probe (1 MHz to 4 GHz) was used to measure the dielectric properties of the LNs obtained from 76 lung cancer patients. According to the results of pathological examination, the LNs were divided into metastatic and non-metastatic LNs, and the metastatic LNs were divided into lung squamous cell carcinomas and adenocarcinoma. The differences in dielectric properties of the LNs were analyzed at 1 MHz to 4 GHz and at 6 single frequencies (64, 128, 298, 433, 915, and 2450 MHz). RESULTS: The metastatic LNs showed higher dielectric properties than non-metastatic LNs in the frequency range from 1 MHz to 4 GHz. No significant differences were found in the dielectric properties between metastatic LNs of lung squamous cell carcinoma and adenocarcinoma. At the 6 single frequencies, the metastatic and non-metastatic LNs showed significant differences in their dielectric properties (P < 0.01). CONCLUSIONS: The open-ended coaxial probe technology is not capable of identifying the pathological type of the primary lung cancer from which the metastatic LNs are derived, but it can identify the differences in dielectric properties between metastatic and non-metastatic LNs, and thus provide a reliable means for identification of LN metastasis of lung cancer.
OBJECTIVE: To investigate the differences in dielectric properties (relative dielectric constant and conductivity) between metastatic and non-metastatic lymph nodes (LNs). METHODS: An open-end coaxial probe (1 MHz to 4 GHz) was used to measure the dielectric properties of the LNs obtained from 76 lung cancerpatients. According to the results of pathological examination, the LNs were divided into metastatic and non-metastatic LNs, and the metastatic LNs were divided into lung squamous cell carcinomas and adenocarcinoma. The differences in dielectric properties of the LNs were analyzed at 1 MHz to 4 GHz and at 6 single frequencies (64, 128, 298, 433, 915, and 2450 MHz). RESULTS: The metastatic LNs showed higher dielectric properties than non-metastatic LNs in the frequency range from 1 MHz to 4 GHz. No significant differences were found in the dielectric properties between metastatic LNs of lung squamous cell carcinoma and adenocarcinoma. At the 6 single frequencies, the metastatic and non-metastatic LNs showed significant differences in their dielectric properties (P < 0.01). CONCLUSIONS: The open-ended coaxial probe technology is not capable of identifying the pathological type of the primary lung cancer from which the metastatic LNs are derived, but it can identify the differences in dielectric properties between metastatic and non-metastatic LNs, and thus provide a reliable means for identification of LN metastasis of lung cancer.
Authors: Paul E Summers; Andrea Vingiani; Salvatore Di Pietro; Andrea Martellosio; Pedro F Espin-Lopez; Simona Di Meo; Marco Pasian; Michele Ghitti; Marco Mangiacotti; Roberto Sacchi; Paolo Veronesi; Maurizio Bozzi; Andrea Mazzanti; Luca Perregrini; Francesco Svelto; Lorenzo Preda; Massimo Bellomi; Giuseppe Renne Journal: Breast Date: 2019-02-27 Impact factor: 4.380
Authors: Jiaen Liu; Qi Shao; Yicun Wang; Gregor Adriany; John Bischof; Pierre-Francois Van de Moortele; Bin He Journal: Magn Reson Med Date: 2017-01-23 Impact factor: 4.668