Neelesh K Nadkarni1,2, Oscar L Lopez2,3,4, Subashan Perera1,5, Stephanie A Studenski6, Beth E Snitz2,3, Kirk I Erickson7, Chester A Mathis8, Robert D Nebes4, Mark Redfern9, William E Klunk2,3,4. 1. Department of Medicine (Geriatric Medicine). 2. Alzheimer's Disease Research Center. 3. Department of Neurology. 4. Department of Psychiatry, and. 5. Department of Biostatistics, University of Pittsburgh, Pennsylvania. 6. NIA Intramural Research Program, Baltimore, Maryland. 7. Department of Psychology. 8. Department of Radiology, and. 9. Swanson School of Engineering, University of Pittsburgh, Pennsylvania.
Abstract
Background: We examined relationships between cerebral amyloid-beta (Aβ) and cognitive-gait dual-task performance in 27 cognitively normal, mobility unimpaired elders. Methods: We assessed Aβ on Pittsburgh Compound B (PiB)-PET. We measured gait speed separately and while performing working-memory, response-inhibition, motor-sequencing, and phone-dialing tasks. We compared dual-task costs on gait and cognitive performance in high-Aβ (PiB(+)) and low-Aβ (PiB(-)) groups and examined the association between Aβ and dual-task performance decrements. Results: PiB(+) (n = 16) were comparable with the PiB(-) (n = 11) individuals on demographics, general cognitive and physical performance, and key brain MRI characteristics. PiB(+) group demonstrated greater dual-task costs on gait speed on all cognitive tasks (p < .05) except on response inhibition. Dual-task costs on cognition were similar between groups. Overall, Aβ was associated with dual-task decrement on gait speed but not on dual-task decrement on cognitive performance. Conclusions: Preliminary evidence indicates that cerebral Aβ is associated with gait slowing on dual-tasking in healthy older adults.
Background: We examined relationships between cerebral amyloid-beta (Aβ) and cognitive-gait dual-task performance in 27 cognitively normal, mobility unimpaired elders. Methods: We assessed Aβ on Pittsburgh Compound B (PiB)-PET. We measured gait speed separately and while performing working-memory, response-inhibition, motor-sequencing, and phone-dialing tasks. We compared dual-task costs on gait and cognitive performance in high-Aβ (PiB(+)) and low-Aβ (PiB(-)) groups and examined the association between Aβ and dual-task performance decrements. Results: PiB(+) (n = 16) were comparable with the PiB(-) (n = 11) individuals on demographics, general cognitive and physical performance, and key brain MRI characteristics. PiB(+) group demonstrated greater dual-task costs on gait speed on all cognitive tasks (p < .05) except on response inhibition. Dual-task costs on cognition were similar between groups. Overall, Aβ was associated with dual-task decrement on gait speed but not on dual-task decrement on cognitive performance. Conclusions: Preliminary evidence indicates that cerebral Aβ is associated with gait slowing on dual-tasking in healthy older adults.
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