Maria Orsaria1, Ambrogio P Londero2,3, Stefania Marzinotto1, Carla Di Loreto1, Diego Marchesoni3, Laura Mariuzzi1. 1. Department of Medical and Biological Sciences, DSMB, University of Udine, Udine, Italy. 2. Unit of Obstetrics and Gynecology, Hospital of Monfalcone (GO), Italy. 3. Department of Experimental Clinical and Medical Science, DISM, Clinic of Obstetrics and Gynecology, University of Udine, Udine, Italy.
Abstract
OBJECTIVE: To analyze the expression profile of placental type alkaline phosphatase (PLAP), cancer antigen 125 (CA125), and human epididymis protein 4 (HE4) in serous ovarian cancer and to correlate their expression with the tumor aggressiveness and progression. METHODS: Retrospective study considering a tissue microarray of 82 women affected by ovarian serous cancer. Protein expression was assessed by immunohistochemistry on ovarian serous cancer tissue samples. Immunohistochemical staining was semiquantitatively evaluated as H-score. RESULTS: Median H-score values were lower for PLAP, 1 (IQR 0-4) than CA125, 10 (IQR 6-12) or HE4, 8 (IQR 5-12). Even if PLAP was less expressed in the cells of serous ovarian cancer than CA125 or HE4 it was relatively more expressed in the fourth quartile of its H-score distribution among cases with low CA125 or HE4 expression. Furthermore, PLAP and HE4 high expression resulted to be significantly correlated with a better prognosis. CONCLUSIONS: PLAP could be an additional marker for early detection of serous ovarian carcinoma, together with the established CA125 and HE4. In addition, PLAP expression is correlated with prognosis, giving, in this way, an additional tool for improving treatment approach.
OBJECTIVE: To analyze the expression profile of placental type alkaline phosphatase (PLAP), cancer antigen 125 (CA125), and humanepididymis protein 4 (HE4) in serous ovarian cancer and to correlate their expression with the tumor aggressiveness and progression. METHODS: Retrospective study considering a tissue microarray of 82 women affected by ovarian serous cancer. Protein expression was assessed by immunohistochemistry on ovarian serous cancer tissue samples. Immunohistochemical staining was semiquantitatively evaluated as H-score. RESULTS: Median H-score values were lower for PLAP, 1 (IQR 0-4) than CA125, 10 (IQR 6-12) or HE4, 8 (IQR 5-12). Even if PLAP was less expressed in the cells of serous ovarian cancer than CA125 or HE4 it was relatively more expressed in the fourth quartile of its H-score distribution among cases with low CA125 or HE4 expression. Furthermore, PLAP and HE4 high expression resulted to be significantly correlated with a better prognosis. CONCLUSIONS:PLAP could be an additional marker for early detection of serous ovarian carcinoma, together with the established CA125 and HE4. In addition, PLAP expression is correlated with prognosis, giving, in this way, an additional tool for improving treatment approach.
Authors: Veronica Barcelona; Yunfeng Huang; Kristen Brown; Jiaxuan Liu; Wei Zhao; Miao Yu; Sharon L R Kardia; Jennifer A Smith; Jacquelyn Y Taylor; Yan V Sun Journal: Epigenetics Date: 2019-03-27 Impact factor: 4.528
Authors: Yang Su; Xin Zhang; Scott Bidlingmaier; Christopher R Behrens; Nam-Kyung Lee; Bin Liu Journal: Cancer Res Date: 2020-08-31 Impact factor: 12.701
Authors: Ulf Gyllensten; Julia Hedlund-Lindberg; Johanna Svensson; Johanna Manninen; Torbjörn Öst; Jon Ramsell; Matilda Åslin; Emma Ivansson; Marta Lomnytska; Maria Lycke; Tomas Axelsson; Ulrika Liljedahl; Jessica Nordlund; Per-Henrik Edqvist; Tobias Sjöblom; Mathias Uhlén; Karin Stålberg; Karin Sundfeldt; Mikael Åberg; Stefan Enroth Journal: Cancers (Basel) Date: 2022-03-30 Impact factor: 6.639
Authors: Viktor Reiswich; Natalia Gorbokon; Andreas M Luebke; Eike Burandt; Anne Menz; Martina Kluth; Claudia Hube-Magg; Corinna Wittmer; Sören Weidemann; Christoph Fraune; Katharina Möller; Patrick Lebok; Guido Sauter; Ronald Simon; Ria Uhlig; Waldemar Wilczak; Frank Jacobsen; Sarah Minner; Rainer Krech; Christian Bernreuther; Andreas Marx; Stefan Steurer; Till Clauditz; Till Krech Journal: J Pathol Clin Res Date: 2021-08-07