| Literature DB >> 27798627 |
Nicola Barban1, Rick Jansen2, Ronald de Vlaming3,4,5, Ahmad Vaez6,7, Jornt J Mandemakers8, Felix C Tropf1, Xia Shen9,10,11, James F Wilson10,11, Daniel I Chasman12, Ilja M Nolte6, Vinicius Tragante13, Sander W van der Laan14, John R B Perry15, Augustine Kong16,17, Tarunveer S Ahluwalia18,19,20, Eva Albrecht21, Laura Yerges-Armstrong22, Gil Atzmon23,24,25, Kirsi Auro26,27, Kristin Ayers28, Andrew Bakshi29, Danny Ben-Avraham24, Klaus Berger30, Aviv Bergman31, Lars Bertram32,33, Lawrence F Bielak34, Gyda Bjornsdottir17, Marc Jan Bonder35, Linda Broer36, Minh Bui37, Caterina Barbieri38, Alana Cavadino39,40, Jorge E Chavarro41,42,43, Constance Turman43, Maria Pina Concas44, Heather J Cordell28, Gail Davies45,46, Peter Eibich47, Nicholas Eriksson48, Tõnu Esko49,50, Joel Eriksson51, Fahimeh Falahi6, Janine F Felix4,52,53, Mark Alan Fontana54, Lude Franke35, Ilaria Gandin55, Audrey J Gaskins41, Christian Gieger56,57, Erica P Gunderson58, Xiuqing Guo59, Caroline Hayward10, Chunyan He60, Edith Hofer61,62, Hongyan Huang43, Peter K Joshi11, Stavroula Kanoni63, Robert Karlsson9, Stefan Kiechl64, Annette Kifley65, Alexander Kluttig66, Peter Kraft43,67, Vasiliki Lagou68,69,70, Cecile Lecoeur71, Jari Lahti72,73,74, Ruifang Li-Gao75, Penelope A Lind76, Tian Liu77, Enes Makalic37, Crysovalanto Mamasoula28, Lindsay Matteson78, Hamdi Mbarek79,80, Patrick F McArdle22, George McMahon81, S Fleur W Meddens5,82, Evelin Mihailov49, Mike Miller83, Stacey A Missmer43,84, Claire Monnereau4,52,53, Peter J van der Most6, Ronny Myhre85, Mike A Nalls86, Teresa Nutile87, Ioanna Panagiota Kalafati88, Eleonora Porcu89,90, Inga Prokopenko91,92,93, Kumar B Rajan94, Janet Rich-Edwards42,43,95, Cornelius A Rietveld3,4,5, Antonietta Robino96, Lynda M Rose12, Rico Rueedi97,98, Kathleen A Ryan22, Yasaman Saba99, Daniel Schmidt37, Jennifer A Smith34, Lisette Stolk36, Elizabeth Streeten22, Anke Tönjes100, Gudmar Thorleifsson17, Sheila Ulivi96, Juho Wedenoja101, Juergen Wellmann30, Peter Willeit64,102,103, Jie Yao59, Loic Yengo71,104, Jing Hua Zhao15, Wei Zhao34, Daria V Zhernakova35, Najaf Amin4, Howard Andrews105, Beverley Balkau71, Nir Barzilai23, Sven Bergmann97,98, Ginevra Biino106, Hans Bisgaard20, Klaus Bønnelykke20, Dorret I Boomsma79,80, Julie E Buring12, Harry Campbell11, Stefania Cappellani96, Marina Ciullo87,107, Simon R Cox45,46, Francesco Cucca89,90, Daniela Toniolo38, George Davey-Smith108, Ian J Deary45,46, George Dedoussis88, Panos Deloukas63,109, Cornelia M van Duijn4, Eco J C de Geus79,80, Johan G Eriksson74,110,111,112,113, Denis A Evans94, Jessica D Faul114, Cinzia Felicita Sala38, Philippe Froguel71, Paolo Gasparini55,115, Giorgia Girotto55,115, Hans-Jörgen Grabe116, Karin Halina Greiser117, Patrick J F Groenen5,118, Hugoline G de Haan75, Johannes Haerting66, Tamara B Harris119, Andrew C Heath120, Kauko Heikkilä27, Albert Hofman4,5,43, Georg Homuth121, Elizabeth G Holliday122,123, John Hopper37, Elina Hyppönen39,124,125, Bo Jacobsson85,126, Vincent W V Jaddoe4,52,53, Magnus Johannesson127, Astanand Jugessur85, Mika Kähönen128, Eero Kajantie129,130,131, Sharon L R Kardia34, Bernard Keavney28,132, Ivana Kolcic133, Päivikki Koponen134, Peter Kovacs135, Florian Kronenberg136, Zoltan Kutalik98,137, Martina La Bianca96, Genevieve Lachance138, William G Iacono83, Sandra Lai89, Terho Lehtimäki139, David C Liewald45, Cecilia M Lindgren92,93,140,141, Yongmei Liu142, Robert Luben141, Michael Lucht110, Riitta Luoto143, Per Magnus85, Patrik K E Magnusson9, Nicholas G Martin76, Matt McGue83,144, Ruth McQuillan11, Sarah E Medland76, Christa Meisinger57,145, Dan Mellström51, Andres Metspalu49,146, Michela Traglia38, Lili Milani49, Paul Mitchell65, Grant W Montgomery120,147, Dennis Mook-Kanamori75,148,149, Renée de Mutsert75, Ellen A Nohr150, Claes Ohlsson51, Jørn Olsen151, Ken K Ong15, Lavinia Paternoster108, Alison Pattie46, Brenda W J H Penninx2,80, Markus Perola26,27,49, Patricia A Peyser34, Mario Pirastu44, Ozren Polasek133, Chris Power39, Jaakko Kaprio26,27,101, Leslie J Raffel152, Katri Räikkönen72, Olli Raitakari153, Paul M Ridker12, Susan M Ring108, Kathryn Roll59, Igor Rudan11, Daniela Ruggiero87, Dan Rujescu154, Veikko Salomaa26, David Schlessinger155, Helena Schmidt99, Reinhold Schmidt61, Nicole Schupf156, Johannes Smit2,80, Rossella Sorice87,107, Tim D Spector138, John M Starr45,157, Doris Stöckl156, Konstantin Strauch21,158, Michael Stumvoll100,135, Morris A Swertz35, Unnur Thorsteinsdottir17,159, A Roy Thurik3,5,160, Nicholas J Timpson108, Joyce Y Tung48, André G Uitterlinden3,5,36, Simona Vaccargiu44, Jorma Viikari161, Veronique Vitart10, Henry Völzke162, Peter Vollenweider163, Dragana Vuckovic55,115, Johannes Waage20, Gert G Wagner164, Jie Jin Wang65, Nicholas J Wareham15, David R Weir114, Gonneke Willemsen79,80, Johann Willeit64, Alan F Wright10, Krina T Zondervan165,166, Kari Stefansson17,159, Robert F Krueger83, James J Lee83, Daniel J Benjamin54,167, David Cesarini168,169, Philipp D Koellinger3,5,82, Marcel den Hoed170, Harold Snieder6, Melinda C Mills1.
Abstract
The genetic architecture of human reproductive behavior-age at first birth (AFB) and number of children ever born (NEB)-has a strong relationship with fitness, human development, infertility and risk of neuropsychiatric disorders. However, very few genetic loci have been identified, and the underlying mechanisms of AFB and NEB are poorly understood. We report a large genome-wide association study of both sexes including 251,151 individuals for AFB and 343,072 individuals for NEB. We identified 12 independent loci that are significantly associated with AFB and/or NEB in a SNP-based genome-wide association study and 4 additional loci associated in a gene-based effort. These loci harbor genes that are likely to have a role, either directly or by affecting non-local gene expression, in human reproduction and infertility, thereby increasing understanding of these complex traits.Entities:
Mesh：
Year: 2016 PMID： 27798627 PMCID： PMC5695684 DOI： 10.1038/ng.3698
Source DB: PubMed Journal: Nat Genet ISSN： 1061-4036 Impact factor: 38.330