Literature DB >> 29064009

The Rotterdam Study: 2018 update on objectives, design and main results.

M Arfan Ikram1,2, Guy G O Brusselle3,4,5, Sarwa Darwish Murad6,7, Cornelia M van Duijn3, Oscar H Franco3,8, André Goedegebure9, Caroline C W Klaver3,10, Tamar E C Nijsten11, Robin P Peeters3,6, Bruno H Stricker3,6, Henning Tiemeier3,12, André G Uitterlinden3,6, Meike W Vernooij3,13, Albert Hofman3,14.   

Abstract

The Rotterdam Study is a prospective cohort study ongoing since 1990 in the city of Rotterdam in The Netherlands. The study targets cardiovascular, endocrine, hepatic, neurological, ophthalmic, psychiatric, dermatological, otolaryngological, locomotor, and respiratory diseases. As of 2008, 14,926 subjects aged 45 years or over comprise the Rotterdam Study cohort. Since 2016, the cohort is being expanded by persons aged 40 years and over. The findings of the Rotterdam Study have been presented in over 1500 research articles and reports (see www.erasmus-epidemiology.nl/rotterdamstudy ). This article gives the rationale of the study and its design. It also presents a summary of the major findings and an update of the objectives and methods.

Entities:  

Keywords:  Biomarkers; Cardiovascular diseases; Cohort study; Dermatological diseases; Endocrine diseases; Epidemiologic methods; Genetic epidemiology; Liver diseases; Neurological diseases; Oncology; Ophthalmic diseases; Otolaryngological diseases; Pharmacoepidemiology; Psychiatric diseases; Renal diseases; Respiratory diseases

Mesh:

Year:  2017        PMID: 29064009      PMCID: PMC5662692          DOI: 10.1007/s10654-017-0321-4

Source DB:  PubMed          Journal:  Eur J Epidemiol        ISSN: 0393-2990            Impact factor:   8.082


  484 in total

1.  Liver fat is related to cardiovascular risk factors and subclinical vascular disease: the Rotterdam Study.

Authors:  Lennard Wolff; Daniel Bos; Sarwa Darwish Murad; Oscar H Franco; Gabriel P Krestin; Albert Hofman; Meike W Vernooij; Aad van der Lugt
Journal:  Eur Heart J Cardiovasc Imaging       Date:  2016-08-22       Impact factor: 6.875

2.  The MC1R Gene and Youthful Looks.

Authors:  Fan Liu; Merel A Hamer; Joris Deelen; Japal S Lall; Leonie Jacobs; Diana van Heemst; Peter G Murray; Andreas Wollstein; Anton J M de Craen; Hae-Won Uh; Changqing Zeng; Albert Hofman; André G Uitterlinden; Jeanine J Houwing-Duistermaat; Luba M Pardo; Marian Beekman; P Eline Slagboom; Tamar Nijsten; Manfred Kayser; David A Gunn
Journal:  Curr Biol       Date:  2016-04-28       Impact factor: 10.834

3.  Disengaging from statistical significance.

Authors:  Kenneth J Rothman
Journal:  Eur J Epidemiol       Date:  2016-06-07       Impact factor: 8.082

4.  A Genome-Wide Association Study Identifies the Skin Color Genes IRF4, MC1R, ASIP, and BNC2 Influencing Facial Pigmented Spots.

Authors:  Leonie C Jacobs; Merel A Hamer; David A Gunn; Joris Deelen; Jaspal S Lall; Diana van Heemst; Hae-Won Uh; Albert Hofman; André G Uitterlinden; Christopher E M Griffiths; Marian Beekman; P Eline Slagboom; Manfred Kayser; Fan Liu; Tamar Nijsten
Journal:  J Invest Dermatol       Date:  2015-02-23       Impact factor: 8.551

5.  N-Terminal Pro-B-Type Natriuretic Peptide Is Related to Retinal Microvascular Damage: The Rotterdam Study.

Authors:  Unal Mutlu; M Arfan Ikram; Albert Hofman; Paulus T V M de Jong; Caroline C W Klaver; M Kamran Ikram
Journal:  Arterioscler Thromb Vasc Biol       Date:  2016-06-23       Impact factor: 8.311

6.  Registers of the Swedish total population and their use in medical research.

Authors:  Jonas F Ludvigsson; Catarina Almqvist; Anna-Karin Edstedt Bonamy; Rickard Ljung; Karl Michaëlsson; Martin Neovius; Olof Stephansson; Weimin Ye
Journal:  Eur J Epidemiol       Date:  2016-01-14       Impact factor: 8.082

7.  Novel associations of multiple genetic loci with plasma levels of factor VII, factor VIII, and von Willebrand factor: The CHARGE (Cohorts for Heart and Aging Research in Genome Epidemiology) Consortium.

Authors:  Nicholas L Smith; Ming-Huei Chen; Abbas Dehghan; David P Strachan; Saonli Basu; Nicole Soranzo; Caroline Hayward; Igor Rudan; Maria Sabater-Lleal; Joshua C Bis; Moniek P M de Maat; Ann Rumley; Xiaoxiao Kong; Qiong Yang; Frances M K Williams; Veronique Vitart; Harry Campbell; Anders Mälarstig; Kerri L Wiggins; Cornelia M Van Duijn; Wendy L McArdle; James S Pankow; Andrew D Johnson; Angela Silveira; Barbara McKnight; Andre G Uitterlinden; Nena Aleksic; James B Meigs; Annette Peters; Wolfgang Koenig; Mary Cushman; Sekar Kathiresan; Jerome I Rotter; Edwin G Bovill; Albert Hofman; Eric Boerwinkle; Geoffrey H Tofler; John F Peden; Bruce M Psaty; Frank Leebeek; Aaron R Folsom; Martin G Larson; Timothy D Spector; Alan F Wright; James F Wilson; Anders Hamsten; Thomas Lumley; Jacqueline C M Witteman; Weihong Tang; Christopher J O'Donnell
Journal:  Circulation       Date:  2010-03-15       Impact factor: 29.690

8.  Genome-wide association analysis identifies six new loci associated with forced vital capacity.

Authors:  Daan W Loth; María Soler Artigas; Sina A Gharib; Louise V Wain; Nora Franceschini; Beate Koch; Tess D Pottinger; Albert Vernon Smith; Qing Duan; Chris Oldmeadow; Mi Kyeong Lee; David P Strachan; Alan L James; Jennifer E Huffman; Veronique Vitart; Adaikalavan Ramasamy; Nicholas J Wareham; Jaakko Kaprio; Xin-Qun Wang; Holly Trochet; Mika Kähönen; Claudia Flexeder; Eva Albrecht; Lorna M Lopez; Kim de Jong; Bharat Thyagarajan; Alexessander Couto Alves; Stefan Enroth; Ernst Omenaas; Peter K Joshi; Tove Fall; Ana Viñuela; Lenore J Launer; Laura R Loehr; Myriam Fornage; Guo Li; Jemma B Wilk; Wenbo Tang; Ani Manichaikul; Lies Lahousse; Tamara B Harris; Kari E North; Alicja R Rudnicka; Jennie Hui; Xiangjun Gu; Thomas Lumley; Alan F Wright; Nicholas D Hastie; Susan Campbell; Rajesh Kumar; Isabelle Pin; Robert A Scott; Kirsi H Pietiläinen; Ida Surakka; Yongmei Liu; Elizabeth G Holliday; Holger Schulz; Joachim Heinrich; Gail Davies; Judith M Vonk; Mary Wojczynski; Anneli Pouta; Asa Johansson; Sarah H Wild; Erik Ingelsson; Fernando Rivadeneira; Henry Völzke; Pirro G Hysi; Gudny Eiriksdottir; Alanna C Morrison; Jerome I Rotter; Wei Gao; Dirkje S Postma; Wendy B White; Stephen S Rich; Albert Hofman; Thor Aspelund; David Couper; Lewis J Smith; Bruce M Psaty; Kurt Lohman; Esteban G Burchard; André G Uitterlinden; Melissa Garcia; Bonnie R Joubert; Wendy L McArdle; A Bill Musk; Nadia Hansel; Susan R Heckbert; Lina Zgaga; Joyce B J van Meurs; Pau Navarro; Igor Rudan; Yeon-Mok Oh; Susan Redline; Deborah L Jarvis; Jing Hua Zhao; Taina Rantanen; George T O'Connor; Samuli Ripatti; Rodney J Scott; Stefan Karrasch; Harald Grallert; Nathan C Gaddis; John M Starr; Cisca Wijmenga; Ryan L Minster; David J Lederer; Juha Pekkanen; Ulf Gyllensten; Harry Campbell; Andrew P Morris; Sven Gläser; Christopher J Hammond; Kristin M Burkart; John Beilby; Stephen B Kritchevsky; Vilmundur Gudnason; Dana B Hancock; O Dale Williams; Ozren Polasek; Tatijana Zemunik; Ivana Kolcic; Marcy F Petrini; Matthias Wjst; Woo Jin Kim; David J Porteous; Generation Scotland; Blair H Smith; Anne Viljanen; Markku Heliövaara; John R Attia; Ian Sayers; Regina Hampel; Christian Gieger; Ian J Deary; H Marike Boezen; Anne Newman; Marjo-Riitta Jarvelin; James F Wilson; Lars Lind; Bruno H Stricker; Alexander Teumer; Timothy D Spector; Erik Melén; Marjolein J Peters; Leslie A Lange; R Graham Barr; Ken R Bracke; Fien M Verhamme; Joohon Sung; Pieter S Hiemstra; Patricia A Cassano; Akshay Sood; Caroline Hayward; Josée Dupuis; Ian P Hall; Guy G Brusselle; Martin D Tobin; Stephanie J London
Journal:  Nat Genet       Date:  2014-06-15       Impact factor: 38.330

9.  Epigenome-wide association study (EWAS) on lipids: the Rotterdam Study.

Authors:  Kim V E Braun; Klodian Dhana; Paul S de Vries; Trudy Voortman; Joyce B J van Meurs; Andre G Uitterlinden; Albert Hofman; Frank B Hu; Oscar H Franco; Abbas Dehghan
Journal:  Clin Epigenetics       Date:  2017-02-07       Impact factor: 6.551

10.  Tobacco smoking is associated with DNA methylation of diabetes susceptibility genes.

Authors:  Symen Ligthart; Rebecca V Steenaard; Marjolein J Peters; Joyce B J van Meurs; Eric J G Sijbrands; André G Uitterlinden; Marc J Bonder; Albert Hofman; Oscar H Franco; Abbas Dehghan
Journal:  Diabetologia       Date:  2016-01-29       Impact factor: 10.122

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  157 in total

Review 1.  Menstrual Cycle Hormone Changes Associated with Reproductive Aging and How They May Relate to Symptoms.

Authors:  Amanda Allshouse; Jelena Pavlovic; Nanette Santoro
Journal:  Obstet Gynecol Clin North Am       Date:  2018-10-25       Impact factor: 2.844

2.  Independent Multiple Factor Association Analysis for Multiblock Data in Imaging Genetics.

Authors:  Natalia Vilor-Tejedor; Mohammad Arfan Ikram; Gennady V Roshchupkin; Alejandro Cáceres; Silvia Alemany; Meike W Vernooij; Wiro J Niessen; Cornelia M van Duijn; Jordi Sunyer; Hieab H Adams; Juan R González
Journal:  Neuroinformatics       Date:  2019-10

3.  Antihypertensive medications and risk for incident dementia and Alzheimer's disease: a meta-analysis of individual participant data from prospective cohort studies.

Authors:  Jie Ding; Kendra L Davis-Plourde; Sanaz Sedaghat; Phillip J Tully; Wanmei Wang; Caroline Phillips; Matthew P Pase; Jayandra J Himali; B Gwen Windham; Michael Griswold; Rebecca Gottesman; Thomas H Mosley; Lon White; Vilmundur Guðnason; Stéphanie Debette; Alexa S Beiser; Sudha Seshadri; M Arfan Ikram; Osorio Meirelles; Christophe Tzourio; Lenore J Launer
Journal:  Lancet Neurol       Date:  2019-11-06       Impact factor: 44.182

Review 4.  Enlarged perivascular spaces and cognition: A meta-analysis of 5 population-based studies.

Authors:  Saima Hilal; Chuen Seng Tan; Hieab H H Adams; Mohamad Habes; Vincent Mok; Narayanaswamy Venketasubramanian; Edith Hofer; M Kamran Ikram; Jill Abrigo; Meike W Vernooij; Christopher Chen; Norbert Hosten; Henry Volzke; Hans J Grabe; Reinhold Schmidt; M Arfan Ikram
Journal:  Neurology       Date:  2018-08-01       Impact factor: 9.910

5.  Gray Matter Age Prediction as a Biomarker for Risk of Dementia.

Authors:  Johnny Wang; Maria J Knol; Aleksei Tiulpin; Florian Dubost; Marleen de Bruijne; Meike W Vernooij; Hieab H H Adams; M Arfan Ikram; Wiro J Niessen; Gennady V Roshchupkin
Journal:  Proc Natl Acad Sci U S A       Date:  2019-10-01       Impact factor: 11.205

6.  Understanding the Time Course of Cancer-Associated Cognitive Decline: Does Impairment Precede Diagnosis?

Authors:  Brent J Small; Heather S L Jim
Journal:  J Natl Cancer Inst       Date:  2020-05-01       Impact factor: 13.506

7.  Mild Cognitive Impairment and Dementia Show Contrasting Associations with Risk of Cancer.

Authors:  Kimberly D van der Willik; Rikje Ruiter; Frank J Wolters; M Kamran Ikram; Bruno H Stricker; Michael Hauptmann; Annette Compter; Sanne B Schagen; M Arfan Ikram
Journal:  Neuroepidemiology       Date:  2018-05-14       Impact factor: 3.282

8.  Associations of statin use with glycaemic traits and incident type 2 diabetes.

Authors:  Fariba Ahmadizar; Carolina Ochoa-Rosales; Marija Glisic; Oscar H Franco; Taulant Muka; Bruno H Stricker
Journal:  Br J Clin Pharmacol       Date:  2019-03-18       Impact factor: 4.335

9.  An Epigenome-Wide Association Study of Obesity-Related Traits.

Authors:  Klodian Dhana; Kim V E Braun; Jana Nano; Trudy Voortman; Ellen W Demerath; Weihua Guan; Myriam Fornage; Joyce B J van Meurs; Andre G Uitterlinden; Albert Hofman; Oscar H Franco; Abbas Dehghan
Journal:  Am J Epidemiol       Date:  2018-08-01       Impact factor: 4.897

10.  Trajectories of Cognitive Function Prior to Cancer Diagnosis: A Population-Based Study.

Authors:  Kimberly D van der Willik; Michael Hauptmann; Katarzyna Jóźwiak; Elisabeth J Vinke; Rikje Ruiter; Bruno H Stricker; Annette Compter; M Arfan Ikram; Sanne B Schagen
Journal:  J Natl Cancer Inst       Date:  2020-05-01       Impact factor: 13.506

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