| Literature DB >> 2779734 |
D A Compston1, B P Morgan, A K Campbell, P Wilkins, G Cole, N D Thomas, B Jasani.
Abstract
Granular deposits of C9 and the terminal complement complex, measuring 0.3-1.2 microns, have been demonstrated immunocytochemically in association with capillary endothelial cells, predominantly within plaques and adjacent white matter, in tissue obtained at autopsy from 5/7 patients with multiple sclerosis (MS) and one individual with subacute sclerosing panencephalitis but not from 7/7 controls. This finding suggests that the evolution of focal tissue damage in MS may involve complement activation associated with passage of humoral and cellular mediators of the immune system through the blood-brain barrier.Entities:
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Year: 1989 PMID： 2779734 DOI： 10.1111/j.1365-2990.1989.tb01231.x
Source DB: PubMed Journal: Neuropathol Appl Neurobiol ISSN： 0305-1846 Impact factor: 8.090