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Literature DB >> 2239153

Anti-macrophage CR3 antibody blocks myelin phagocytosis by macrophages in vitro.

Abstract

Myelin phagocytosis in Wallerian degeneration of peripheral nerves depends on invasion of nerves by non-resident macrophages. The present study was done to clarify the role of the macrophage complement receptor type 3 (CR3) in myelin removal. Myelin phagocytic capacity of invading macrophages was abolished by treatment of cultured nerves and macrophages with anti-CR3 antibody or by serum complement depletion with cobra venom factor. This indicates that myelin phagocytosis is mediated by the macrophage CR3.

Entities: Disease

Mesh：

Substances：
Macrophage-1 Antigen

Year: 1990 PMID： 2239153 DOI： 10.1007/bf00307696

Source DB: PubMed Journal: Acta Neuropathol ISSN： 0001-6322 Impact factor: 17.088

21 in total

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Journal: Brain Res Date: 1986-08-06 Impact factor: 3.252

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Authors: W Brück; R L Friede
Journal: J Neuroimmunol Date: 1989-11 Impact factor: 3.478

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Authors: D A Compston; B P Morgan; A K Campbell; P Wilkins; G Cole; N D Thomas; B Jasani
Journal: Neuropathol Appl Neurobiol Date: 1989 Jul-Aug Impact factor: 8.090

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Authors: W Beuche; R L Friede
Journal: J Neurocytol Date: 1984-10

6. The role of complement in the pathogenesis of experimental allergic encephalomyelitis.

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Journal: Brain Date: 1989-08 Impact factor: 13.501

7. Immunohistochemical localisation of terminal complement component C9 in experimental allergic encephalomyelitis.

Authors: C Linington; H Lassmann; B P Morgan; D A Compston
Journal: Acta Neuropathol Date: 1989 Impact factor: 17.088

8. Myelin phagocytosis in Wallerian degeneration. Properties of millipore diffusion chambers and immunohistochemical identification of cell populations.

Authors: P Scheidt; R L Friede
Journal: Acta Neuropathol Date: 1987 Impact factor: 17.088

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Authors: D I Beller; T A Springer; R D Schreiber
Journal: J Exp Med Date: 1982-10-01 Impact factor: 14.307

10. Augmentation of macrophage complement receptor function in vitro. IV. The lymphokine that activates macrophage C3 receptors for phagocytosis binds to a fucose-bearing glycoprotein on the macrophage plasma membrane.

Authors: F M Griffin; P J Mullinax
Journal: J Exp Med Date: 1984-10-01 Impact factor: 14.307

30 in total

1. Macrophages are eliminated from the injured peripheral nerve via local apoptosis and circulation to regional lymph nodes and the spleen.

Authors: T Kuhlmann; A Bitsch; C Stadelmann; H Siebert; W Brück
Journal: J Neurosci Date: 2001-05-15 Impact factor: 6.167

2. Disruption of the beta2-integrin CD11d (alphaDbeta2) gene fails to protect against experimental autoimmune encephalomyelitis.

Authors: Jillian E Adams; Matthew S Webb; Xianchen Hu; Don Staunton; Scott R Barnum
Journal: J Neuroimmunol Date: 2007-01-23 Impact factor: 3.478

3. Lesion of the rat entorhinal cortex leads to a rapid microglial reaction in the dentate gyrus. A light and electron microscopical study.

Authors: J Gehrmann; S W Schoen; G W Kreutzberg
Journal: Acta Neuropathol Date: 1991 Impact factor: 17.088

4. Complement depletion reduces macrophage infiltration and activation during Wallerian degeneration and axonal regeneration.

Authors: A T Dailey; A M Avellino; L Benthem; J Silver; M Kliot
Journal: J Neurosci Date: 1998-09-01 Impact factor: 6.167

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Authors: J Bauer; S R Ruuls; I Huitinga; C D Dijkstra
Journal: Histochem J Date: 1996-02

6. A role for complement in phagocytosis of myelin.

Authors: B A DeJong; M E Smith
Journal: Neurochem Res Date: 1997-04 Impact factor: 3.996

Review 7. Myelin as an inflammatory mediator: Myelin interactions with complement, macrophages, and microglia in spinal cord injury.

Authors: Timothy J Kopper; John C Gensel
Journal: J Neurosci Res Date: 2017-07-11 Impact factor: 4.164

8. Immunoenrichment microwave and magnetic proteomics for quantifying CD47 in the experimental autoimmune encephalomyelitis model of multiple sclerosis.

Authors: Swetha Mahesula; Itay Raphael; Rekha Raghunathan; Karan Kalsaria; Venkat Kotagiri; Anjali B Purkar; Manjushree Anjanappa; Darshit Shah; Vidya Pericherla; Yeshwant Lal Avinash Jadhav; Jonathan A L Gelfond; Thomas G Forsthuber; William E Haskins
Journal: Electrophoresis Date: 2012-12 Impact factor: 3.535

Review 9. Phagocytosis of myelin in demyelinative disease: a review.

Authors: M E Smith
Journal: Neurochem Res Date: 1999-02 Impact factor: 3.996

Review 10. The complement cascade: Yin-Yang in neuroinflammation--neuro-protection and -degeneration.

Authors: Jessy John Alexander; Aileen Judith Anderson; Scott Robert Barnum; Beth Stevens; Andrea Joan Tenner
Journal: J Neurochem Date: 2008-10-24 Impact factor: 5.372