Literature DB >> 27796496

Clinical application of the LARS score: results from a pilot study.

Yolanda Ribas1, Francesc Aguilar2, Esther Jovell-Fernández3, Ladislao Cayetano2, Albert Navarro-Luna4, Arantxa Muñoz-Duyos4.   

Abstract

PURPOSE: The impact of the low anterior resection syndrome (LARS) on quality of life has underscored the importance of measuring functional outcomes after treatment for rectal cancer. The aim of this study was to evaluate whether the LARS score as a single questionnaire was useful enough in the clinical setting.
METHODS: Patients treated by curative anterior resection for rectal cancer were sent the LARS score and the European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire-Core 30 questionnaires by post. Patients classified as "minor" and "major" LARS according to the LARS score were visited. Assessment included several scores (Vaizey score, Altomare Obstructed Defecation Syndrome score, Bristol scale). Patients with urgency/faecal incontinence also filled in a bowel diary and the FIQL score.
RESULTS: Seventy patients returned the questionnaires, 49 of whom ("major LARS" and "minor LARS") were visited and 19 ("no LARS") were assessed by phone. Four different clinical patterns were identified. The group with urgency/faecal incontinence was the largest (33.8 %), whereas 17.7 % referred evacuatory dysfunction. The LARS score did not correctly evaluate 18 patients: 5 who were classified as no LARS but had severe evacuatory dysfunction and 13 patients categorized as LARS but without significant bowel dysfunction, 9 of whom were classified as major LARS.
CONCLUSION: The LARS score may overestimate the impact on quality of life in some patients and may underestimate the impact of severe evacuatory dysfunction. Due to the complexity of the LARS, the LARS score as a single questionnaire might not be enough to assess bowel function. A complete clinical evaluation and additional questionnaires might be required.

Entities:  

Keywords:  Evacuatory dysfunction; Faecal incontinence; LARS score; Low anterior resection syndrome; Rectal cancer

Mesh:

Year:  2016        PMID: 27796496     DOI: 10.1007/s00384-016-2690-7

Source DB:  PubMed          Journal:  Int J Colorectal Dis        ISSN: 0179-1958            Impact factor:   2.571


  14 in total

Review 1.  The long-term gastrointestinal functional outcomes following curative anterior resection in adults with rectal cancer: a systematic review and meta-analysis.

Authors:  Adena S Scheer; Robin P Boushey; Shuyin Liang; Steve Doucette; Annette M O'Connor; David Moher
Journal:  Dis Colon Rectum       Date:  2011-12       Impact factor: 4.585

Review 2.  Anterior resection syndrome.

Authors:  Catherine L C Bryant; Peter J Lunniss; Charles H Knowles; Mohamed A Thaha; Christopher L H Chan
Journal:  Lancet Oncol       Date:  2012-09       Impact factor: 41.316

3.  International validation of the low anterior resection syndrome score.

Authors:  Therese Juul; Madelene Ahlberg; Sebastiano Biondo; Katrine Jøssing Emmertsen; Eloy Espin; Luis Miguel Jimenez; Klaus E Matzel; Gabriella Palmer; Anna Sauermann; Loris Trenti; Wei Zhang; Søren Laurberg; Peter Christensen
Journal:  Ann Surg       Date:  2014-04       Impact factor: 12.969

4.  Low anterior resection syndrome score: development and validation of a symptom-based scoring system for bowel dysfunction after low anterior resection for rectal cancer.

Authors:  Katrine J Emmertsen; Søren Laurberg
Journal:  Ann Surg       Date:  2012-05       Impact factor: 12.969

5.  Low anterior resection syndrome and quality of life: an international multicenter study.

Authors:  Therese Juul; Madelene Ahlberg; Sebastiano Biondo; Eloy Espin; Luis Miguel Jimenez; Klaus E Matzel; Gabriella Jansson Palmer; Anna Sauermann; Loris Trenti; Wei Zhang; Søren Laurberg; Peter Christensen
Journal:  Dis Colon Rectum       Date:  2014-05       Impact factor: 4.585

6.  Predicting the Risk of Bowel-Related Quality-of-Life Impairment After Restorative Resection for Rectal Cancer: A Multicenter Cross-Sectional Study.

Authors:  Nick J Battersby; Therese Juul; Peter Christensen; Ahmed Z Janjua; Graham Branagan; Katrine J Emmertsen; Christine Norton; Robert Hughes; Søren Laurberg; Brendan J Moran
Journal:  Dis Colon Rectum       Date:  2016-04       Impact factor: 4.585

7.  The European Organization for Research and Treatment of Cancer QLQ-C30: a quality-of-life instrument for use in international clinical trials in oncology.

Authors:  N K Aaronson; S Ahmedzai; B Bergman; M Bullinger; A Cull; N J Duez; A Filiberti; H Flechtner; S B Fleishman; J C de Haes
Journal:  J Natl Cancer Inst       Date:  1993-03-03       Impact factor: 13.506

8.  Impact of bowel dysfunction on quality of life after sphincter-preserving resection for rectal cancer.

Authors:  K J Emmertsen; S Laurberg
Journal:  Br J Surg       Date:  2013-09       Impact factor: 6.939

9.  Practice guidance on the management of acute and chronic gastrointestinal problems arising as a result of treatment for cancer.

Authors:  H Jervoise N Andreyev; Susan E Davidson; Catherine Gillespie; William H Allum; Edwin Swarbrick
Journal:  Gut       Date:  2011-11-04       Impact factor: 23.059

Review 10.  What Are the Best Questionnaires To Capture Anorectal Function After Surgery in Rectal Cancer?

Authors:  Tina Yen-Ting Chen; Katrine J Emmertsen; Søren Laurberg
Journal:  Curr Colorectal Cancer Rep       Date:  2015
View more
  15 in total

1.  How useful is the LARS score in the evaluation and treatment of LARS?

Authors:  Y Ribas; A Muñoz-Duyos
Journal:  Tech Coloproctol       Date:  2019-02-22       Impact factor: 3.781

Review 2.  The incidence and risk factors of low anterior resection syndrome (LARS) after sphincter-preserving surgery of rectal cancer: a systematic review and meta-analysis.

Authors:  Rui Sun; Ziyi Dai; Yin Zhang; Junyang Lu; Yuelun Zhang; Yi Xiao
Journal:  Support Care Cancer       Date:  2021-07-23       Impact factor: 3.603

3.  Trajectory of change of low anterior resection syndrome over time after restorative proctectomy for rectal adenocarcinoma.

Authors:  F Al-Rashid; S Robitaille; A S Liberman; P Charlebois; B Stein; L S Feldman; J F Fiore; L Lee
Journal:  Tech Coloproctol       Date:  2022-01-18       Impact factor: 3.781

4.  The evaluation of postoperative bowel dysfunction in Japanese patients with rectal cancer.

Authors:  Yuki Kiyozumi; Toshiya Nagasaki; Shimpei Matsui; Toshiki Mukai; Yukiharu Hiyoshi; Tomohiro Yamaguchi; Takashi Akiyoshi; Yosuke Fukunaga
Journal:  Surg Today       Date:  2022-10-05       Impact factor: 2.540

Review 5.  The impact of bowel dysfunction on health-related quality of life after rectal cancer surgery: a systematic review.

Authors:  F Al Rashid; A S Liberman; P Charlebois; B Stein; L S Feldman; J F Fiore; L Lee
Journal:  Tech Coloproctol       Date:  2022-03-03       Impact factor: 3.699

6.  Comparative analysis of the Memorial Sloan Kettering Bowel Function Instrument and the Low Anterior Resection Syndrome Questionnaire for assessment of bowel dysfunction in rectal cancer patients after low anterior resection.

Authors:  Felipe F Quezada-Diaz; Hossam Elfeki; Katrine J Emmertsen; Emmanouil P Pappou; Rosa Jimenez-Rodriguez; Sujata Patil; Søren Laurberg; Julio Garcia-Aguilar
Journal:  Colorectal Dis       Date:  2021-02-10       Impact factor: 3.917

7.  Validation of The Slovenian Version of the Low Anterior Resection Syndrome Score for Rectal Cancer Patients after Surgery.

Authors:  Jan Grosek; Jurij Aleš Košir; Jerica Novak; Mirko Omejc; Aleš Tomažič; Gregor Norčič
Journal:  Zdr Varst       Date:  2019-10-01

8.  Randomised controlled trial to assess efficacy of pelvic floor muscle training on bowel symptoms after low anterior resection for rectal cancer: study protocol.

Authors:  Anne Asnong; André D'Hoore; Marijke Van Kampen; Nele Devoogdt; An De Groef; Kim Sterckx; Hilde Lemkens; Albert Wolthuis; Yves Van Molhem; Bart Van Geluwe; Lynn Debrun; Inge Geraerts
Journal:  BMJ Open       Date:  2021-01-22       Impact factor: 2.692

9.  Management guidelines for low anterior resection syndrome - the MANUEL project.

Authors:  Peter Christensen; Coen Im Baeten; Eloy Espín-Basany; Jacopo Martellucci; Karen P Nugent; Frank Zerbib; Gianluca Pellino; Harald Rosen
Journal:  Colorectal Dis       Date:  2021-01-24       Impact factor: 3.788

10.  International Consensus Definition of Low Anterior Resection Syndrome.

Authors:  Celia Keane; Nicola S Fearnhead; Liliana G Bordeianou; Peter Christensen; Eloy Espin Basany; Søren Laurberg; Anders Mellgren; Craig Messick; Guy R Orangio; Azmina Verjee; Kirsty Wing; Ian Bissett
Journal:  Dis Colon Rectum       Date:  2020-03       Impact factor: 4.412

View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.