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Literature DB >> 2779559

Alternative splicing of the platelet-derived growth factor A-chain transcript occurs in normal as well as tumor cells and is conserved among mammalian species.

B Matoskova¹, F Rorsman, V Svensson, C Betsholtz.

Abstract

Using a polymerase chain reaction approach, we have analyzed the alternative usage of the platelet-derived growth factor A-chain exon 6 in mRNA from various cell types. The results show that this sequence is utilized in a small fraction of the mRNA molecules in normal as well as transformed cells and that this phenomenon is conserved among mammalian species.

Entities: Disease Species

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Year: 1989 PMID： 2779559 PMCID： PMC362791 DOI： 10.1128/mcb.9.7.3148-3150.1989

Source DB: PubMed Journal: Mol Cell Biol ISSN： 0270-7306 Impact factor: 4.272

25 in total

1. A significant part of macrophage-derived growth factor consists of at least two forms of PDGF.

Authors: K Shimokado; E W Raines; D K Madtes; T B Barrett; E P Benditt; R Ross
Journal: Cell Date: 1985-11 Impact factor: 41.582

2. Enzymatic amplification of beta-globin genomic sequences and restriction site analysis for diagnosis of sickle cell anemia.

Authors: R K Saiki; S Scharf; F Faloona; K B Mullis; G T Horn; H A Erlich; N Arnheim
Journal: Science Date: 1985-12-20 Impact factor: 47.728

3. Structure of the receptor for platelet-derived growth factor helps define a family of closely related growth factor receptors.

Authors: Y Yarden; J A Escobedo; W J Kuang; T L Yang-Feng; T O Daniel; P M Tremble; E Y Chen; M E Ando; R N Harkins; U Francke
Journal: Nature Date: 1986 Sep 18-24 Impact factor: 49.962

4. Alternative RNA splicing affects function of encoded platelet-derived growth factor A chain.

Authors: T Collins; D T Bonthron; S H Orkin
Journal: Nature Date: 1987 Aug 13-19 Impact factor: 49.962

5. Activated human monocytes express the c-sis proto-oncogene and release a mediator showing PDGF-like activity.

Authors: Y Martinet; P B Bitterman; J F Mornex; G R Grotendorst; G R Martin; R G Crystal
Journal: Nature Date: 1986 Jan 9-15 Impact factor: 49.962

6. Rat skeletal myoblasts and arterial smooth muscle cells express the gene for the A chain but not the gene for the B chain (c-sis) of platelet-derived growth factor (PDGF) and produce a PDGF-like protein.

Authors: T Sejersen; C Betsholtz; M Sjölund; C H Heldin; B Westermark; J Thyberg
Journal: Proc Natl Acad Sci U S A Date: 1986-09 Impact factor: 11.205

7. Possible positive autocrine feedback in the prereplicative phase of human fibroblasts.

Authors: Y Paulsson; A Hammacher; C H Heldin; B Westermark
Journal: Nature Date: 1987 Aug 20-26 Impact factor: 49.962

8. A human osteosarcoma cell line secretes a growth factor structurally related to a homodimer of PDGF A-chains.

Authors: C H Heldin; A Johnsson; S Wennergren; C Wernstedt; C Betsholtz; B Westermark
Journal: Nature Date: 1986 Feb 6-12 Impact factor: 49.962

9. cDNA sequence and chromosomal localization of human platelet-derived growth factor A-chain and its expression in tumour cell lines.

Authors: C Betsholtz; A Johnsson; C H Heldin; B Westermark; P Lind; M S Urdea; R Eddy; T B Shows; K Philpott; A L Mellor
Journal: Nature Date: 1986 Apr 24-30 Impact factor: 49.962

10. Purification of mouse immunoglobulin heavy-chain messenger RNAs from total myeloma tumor RNA.

Authors: C Auffray; F Rougeon
Journal: Eur J Biochem Date: 1980-06

11 in total

1. Alternatively spliced platelet-derived growth factor A-chain transcripts are not tumor specific but encode normal cellular proteins.

Authors: R M Young; A E Mendoza; T Collins; S H Orkin
Journal: Mol Cell Biol Date: 1990-11 Impact factor: 4.272

2. Heparin-like glycosaminoglycans influence growth and phenotype of human arterial smooth muscle cells in vitro. II. The platelet-derived growth factor A-chain contains a sequence that specifically binds heparin.

Authors: G Fager; G Camejo; U Olsson; G Ostergren-Lundén; G Bondjers
Journal: In Vitro Cell Dev Biol Date: 1992-03

3. Differential binding of platelet-derived growth factor isoforms to glycosaminoglycans.

Authors: Raquel García-Olivas; Johan Hoebeke; Susanna Castel; Manuel Reina; Gunnar Fager; Florentina Lustig; Senén Vilaró
Journal: Histochem Cell Biol Date: 2003-10-14 Impact factor: 4.304

4. Identification of a cell retention signal in the B-chain of platelet-derived growth factor and in the long splice version of the A-chain.

Authors: A Ostman; M Andersson; C Betsholtz; B Westermark; C H Heldin
Journal: Cell Regul Date: 1991-07

5. Analysis of mice lacking the heparin-binding splice isoform of platelet-derived growth factor A.

Authors: Johanna Andrae; Hans Ehrencrona; Radiosa Gallini; Mark Lal; Hao Ding; Christer Betsholtz
Journal: Mol Cell Biol Date: 2013-08-12 Impact factor: 4.272

6. Detection of platelet-derived growth factor (PDGF)-AA in actively healing human wounds treated with recombinant PDGF-BB and absence of PDGF in chronic nonhealing wounds.

Authors: G F Pierce; J E Tarpley; J Tseng; J Bready; D Chang; W C Kenney; R Rudolph; M C Robson; J Vande Berg; P Reid
Journal: J Clin Invest Date: 1995-09 Impact factor: 14.808