Literature DB >> 3754619

cDNA sequence and chromosomal localization of human platelet-derived growth factor A-chain and its expression in tumour cell lines.

C Betsholtz, A Johnsson, C H Heldin, B Westermark, P Lind, M S Urdea, R Eddy, T B Shows, K Philpott, A L Mellor.   

Abstract

The amino-acid sequence of the precursor of the human tumour cell line-derived platelet-derived growth factor (PDGF) A-chain has been deduced from complementary DNA clones and the gene localized to chromosome 7. The protein shows extensive homology to the PDGF B-chain precursor. Expression of the PDGF A-chain gene is independent of that of the PDGF B-chain in a number of human tumour cell lines, and secretion of a PDGF-like growth factor of relative molecular mass 31,000 correlates with expression of A- but not B-chain messenger RNA.

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Year:  1986        PMID： 3754619     DOI： 10.1038/320695a0

Source DB:  PubMed          Journal:  Nature        ISSN： 0028-0836            Impact factor:   49.962


  156 in total

Review 1.  Molecular aspects of pathological processes in the artery wall.

Authors:  J W van Neck; H P Bloemers
Journal:  Mol Biol Rep       Date:  1992-11       Impact factor: 2.316

2.  Expression of platelet-derived growth factor and its receptors in proliferative disorders of fibroblastic origin.

Authors:  A Smits; K Funa; F S Vassbotn; M Beausang-Linder; F af Ekenstam; C H Heldin; B Westermark; M Nistér
Journal:  Am J Pathol       Date:  1992-03       Impact factor: 4.307

Review 3.  The extracellular regulation of growth factor action.

Authors:  R Flaumenhaft; D B Rifkin
Journal:  Mol Biol Cell       Date:  1992-10       Impact factor: 4.138

4.  Recent developments in the structure, function and regulation of platelet-derived growth factor and its receptors.

Authors:  J Tiesman; A Rizzino
Journal:  Cytotechnology       Date:  1989-12       Impact factor: 2.058

5.  Distribution and possible role of PDGF-AA and PDGFR-alpha in the gastrointestinal tract of adult guinea pigs.

Authors:  Fangxiao Chan; Yong Liu; Haimei Sun; Xiaoshuang Li; Hongwei Shang; Dongying Fan; Jing An; Deshan Zhou
Journal:  Virchows Arch       Date:  2010-07-15       Impact factor: 4.064

6.  Independent expression of human alpha or beta platelet-derived growth factor receptor cDNAs in a naive hematopoietic cell leads to functional coupling with mitogenic and chemotactic signaling pathways.

Authors:  T Matsui; J H Pierce; T P Fleming; J S Greenberger; W J LaRochelle; M Ruggiero; S A Aaronson
Journal:  Proc Natl Acad Sci U S A       Date:  1989-11       Impact factor: 11.205

7.  Platelet-derived growth factor (PDGF) BB homodimer regulates PDGF A- and PDGF B-chain gene transcription in human mesangial cells.

Authors:  B Bhandari; G Grandaliano; H E Abboud
Journal:  Biochem J       Date:  1994-01-15       Impact factor: 3.857

8.  Growth factor expression in aorta of normotensive and hypertensive rats.

Authors:  R Sarzani; P Brecher; A V Chobanian
Journal:  J Clin Invest       Date:  1989-04       Impact factor: 14.808

9.  Sequences of the 5' portion of the human c-sis gene: characterization of the transcriptional promoter and regulation of expression of the protein product by 5' untranslated mRNA sequences.

Authors:  L Ratner; B Thielan; T Collins
Journal:  Nucleic Acids Res       Date:  1987-08-11       Impact factor: 16.971

10.  Expression of growth factors and their receptors in human esophageal carcinomas: regulation of expression by epidermal growth factor and transforming growth factor alpha.

Authors:  K Yoshida; H Kuniyasu; W Yasui; Y Kitadai; T Toge; E Tahara
Journal:  J Cancer Res Clin Oncol       Date:  1993       Impact factor: 4.553
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