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Literature DB >> 2233732

Alternatively spliced platelet-derived growth factor A-chain transcripts are not tumor specific but encode normal cellular proteins.

R M Young¹, A E Mendoza, T Collins, S H Orkin.

Abstract

Two platelet-derived growth factor A-chain proteins, termed short and long A chains, are generated as a result of alternative mRNA splicing of exon 6 of the A-chain gene. S1 nuclease mapping and polymerase chain reaction analyses demonstrate that both short and long A-chain transcripts are expressed in a variety of normal tissues. In addition, immunohistochemical localization of long A-chain protein reveals a cellular distribution identical to that observed with platelet-derived growth factor heteroserum.

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Year: 1990 PMID： 2233732 PMCID： PMC361404 DOI： 10.1128/mcb.10.11.6051-6054.1990

Source DB: PubMed Journal: Mol Cell Biol ISSN： 0270-7306 Impact factor: 4.272

22 in total

1. Enzyme coupled immunoassay of insulin using a novel coupling reagent.

Authors: T Kitagawa; T Aikawa
Journal: J Biochem Date: 1976-01 Impact factor: 3.387

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Authors: R Ross; E W Raines; D F Bowen-Pope
Journal: Cell Date: 1986-07-18 Impact factor: 41.582

3. Increased platelet-derived growth factor A-chain expression in human uterine smooth muscle cells during the physiologic hypertrophy of pregnancy.

Authors: A E Mendoza; R Young; S H Orkin; T Collins
Journal: Proc Natl Acad Sci U S A Date: 1990-03 Impact factor: 11.205

4. Alternative RNA splicing affects function of encoded platelet-derived growth factor A chain.

Authors: T Collins; D T Bonthron; S H Orkin
Journal: Nature Date: 1987 Aug 13-19 Impact factor: 49.962

5. Platelet-derived growth factor. I. High yield purification and evidence for multiple forms.

Authors: E W Raines; R Ross
Journal: J Biol Chem Date: 1982-05-10 Impact factor: 5.157

6. Human platelet-derived growth factor (PDGF): purification of PDGF-I and PDGF-II and separation of their reduced subunits.

Authors: H N Antoniades
Journal: Proc Natl Acad Sci U S A Date: 1981-12 Impact factor: 11.205

7. Rat skeletal myoblasts and arterial smooth muscle cells express the gene for the A chain but not the gene for the B chain (c-sis) of platelet-derived growth factor (PDGF) and produce a PDGF-like protein.

Authors: T Sejersen; C Betsholtz; M Sjölund; C H Heldin; B Westermark; J Thyberg
Journal: Proc Natl Acad Sci U S A Date: 1986-09 Impact factor: 11.205

8. Platelet-derived growth factor. Isolation by a large-scale procedure and analysis of subunit composition.

Authors: C H Heldin; B Westermark; A Wasteson
Journal: Biochem J Date: 1981-03-01 Impact factor: 3.857

9. Erythroid-specific expression of human beta-globin genes in transgenic mice.

Authors: T M Townes; J B Lingrel; H Y Chen; R L Brinster; R D Palmiter
Journal: EMBO J Date: 1985-07 Impact factor: 11.598

10. Purification and properties of porcine platelet-derived growth factor.

Authors: P Stroobant; M D Waterfield
Journal: EMBO J Date: 1984-12-01 Impact factor: 11.598

6 in total

1. Differential binding of platelet-derived growth factor isoforms to glycosaminoglycans.

Authors: Raquel García-Olivas; Johan Hoebeke; Susanna Castel; Manuel Reina; Gunnar Fager; Florentina Lustig; Senén Vilaró
Journal: Histochem Cell Biol Date: 2003-10-14 Impact factor: 4.304

2. Detection of platelet-derived growth factor (PDGF)-AA in actively healing human wounds treated with recombinant PDGF-BB and absence of PDGF in chronic nonhealing wounds.

Authors: G F Pierce; J E Tarpley; J Tseng; J Bready; D Chang; W C Kenney; R Rudolph; M C Robson; J Vande Berg; P Reid
Journal: J Clin Invest Date: 1995-09 Impact factor: 14.808