Kevin Sam1, Boris Peltenburg1, John Conklin1, Olivia Sobczyk1, Julien Poublanc1, Adrian P Crawley1, Daniel M Mandell1, Lakshmikumar Venkatraghavan1, James Duffin1, Joseph A Fisher1, Sandra E Black1, David J Mikulis2. 1. From the Department of Physiology (K.S., J.D., J.A.F.), Division of Neuroradiology, Joint Department of Medical Imaging, Toronto Western Hospital (K.S., J.C., O.S., J.P., A.P.C., D.M.M., D.J.M.), Department of Medical Imaging (A.P.C., D.M.M., D.J.M.), and Department of Anaesthesia, Toronto General Hospital (L.V., J.D., J.A.F.), The University of Toronto, Canada; Department of Radiotherapy (B.P.), Imaging Division, University Medical Center Utrecht, Utrecht University, the Netherlands; and L.C. Campbell Cognitive Neurology Research Unit (S.E.B.), Sunnybrook Health Sciences Centre, Toronto, Canada. 2. From the Department of Physiology (K.S., J.D., J.A.F.), Division of Neuroradiology, Joint Department of Medical Imaging, Toronto Western Hospital (K.S., J.C., O.S., J.P., A.P.C., D.M.M., D.J.M.), Department of Medical Imaging (A.P.C., D.M.M., D.J.M.), and Department of Anaesthesia, Toronto General Hospital (L.V., J.D., J.A.F.), The University of Toronto, Canada; Department of Radiotherapy (B.P.), Imaging Division, University Medical Center Utrecht, Utrecht University, the Netherlands; and L.C. Campbell Cognitive Neurology Research Unit (S.E.B.), Sunnybrook Health Sciences Centre, Toronto, Canada. mikulis@uhnres.utoronto.ca.
Abstract
OBJECTIVE: To compare the diffusion and perfusion MRI metrics of normal-appearing white matter (NAWM) with and without impaired cerebrovascular reactivity (CVR). METHODS: Seventy-five participants with moderate to severe leukoaraiosis underwent blood oxygen level-dependent CVR mapping using a 3T MRI system with precise carbon dioxide stimulus manipulation. Several MRI metrics were statistically compared between areas of NAWM with positive and negative CVR using one-way analysis of variance with Bonferroni correction for multiple comparisons. RESULTS: Areas of NAWM with negative CVR showed a significant reduction in fractional anisotropy by a mean (SD) of 3.7% (2.4), cerebral blood flow by 22.1% (8.2), regional cerebral blood volume by 22.2% (7.0), and a significant increase in mean diffusivity by 3.9% (3.1) and time to maximum by 10.9% (13.2) (p < 0.01), compared to areas with positive CVR. CONCLUSIONS: Impaired CVR is associated with subtle changes in the tissue integrity of NAWM, as evaluated using several quantitative diffusion and perfusion MRI metrics. These findings suggest that impaired CVR may contribute to the progression of white matter disease.
OBJECTIVE: To compare the diffusion and perfusion MRI metrics of normal-appearing white matter (NAWM) with and without impaired cerebrovascular reactivity (CVR). METHODS: Seventy-five participants with moderate to severe leukoaraiosis underwent blood oxygen level-dependent CVR mapping using a 3T MRI system with precise carbon dioxide stimulus manipulation. Several MRI metrics were statistically compared between areas of NAWM with positive and negative CVR using one-way analysis of variance with Bonferroni correction for multiple comparisons. RESULTS: Areas of NAWM with negative CVR showed a significant reduction in fractional anisotropy by a mean (SD) of 3.7% (2.4), cerebral blood flow by 22.1% (8.2), regional cerebral blood volume by 22.2% (7.0), and a significant increase in mean diffusivity by 3.9% (3.1) and time to maximum by 10.9% (13.2) (p < 0.01), compared to areas with positive CVR. CONCLUSIONS: Impaired CVR is associated with subtle changes in the tissue integrity of NAWM, as evaluated using several quantitative diffusion and perfusion MRI metrics. These findings suggest that impaired CVR may contribute to the progression of white matter disease.
Authors: A Vesely; H Sasano; G Volgyesi; R Somogyi; J Tesler; L Fedorko; J Grynspan; A Crawley; J A Fisher; D Mikulis Journal: Magn Reson Med Date: 2001-06 Impact factor: 4.668
Authors: Stephen M Smith; Mark Jenkinson; Mark W Woolrich; Christian F Beckmann; Timothy E J Behrens; Heidi Johansen-Berg; Peter R Bannister; Marilena De Luca; Ivana Drobnjak; David E Flitney; Rami K Niazy; James Saunders; John Vickers; Yongyue Zhang; Nicola De Stefano; J Michael Brady; Paul M Matthews Journal: Neuroimage Date: 2004 Impact factor: 6.556
Authors: Jorn Fierstra; Julien Poublanc; Jay Shou Han; Frank Silver; Michael Tymianski; Adrian Phillip Crawley; Joseph Arnold Fisher; David John Mikulis Journal: J Neurol Neurosurg Psychiatry Date: 2010-03 Impact factor: 10.154
Authors: F E de Leeuw; J C de Groot; E Achten; M Oudkerk; L M Ramos; R Heijboer; A Hofman; J Jolles; J van Gijn; M M Breteler Journal: J Neurol Neurosurg Psychiatry Date: 2001-01 Impact factor: 10.154
Authors: M O'Sullivan; D J Lythgoe; A C Pereira; P E Summers; J M Jarosz; S C R Williams; H S Markus Journal: Neurology Date: 2002-08-13 Impact factor: 9.910
Authors: Alastair J S Webb; Michela Simoni; Sara Mazzucco; Wilhelm Kuker; Ursula Schulz; Peter M Rothwell Journal: Stroke Date: 2012-08-23 Impact factor: 7.914
Authors: William Reginold; Kevin Sam; Julien Poublanc; Joe Fisher; Adrian Crawley; David J Mikulis Journal: Hum Brain Mapp Date: 2019-05-21 Impact factor: 5.038
Authors: Moss Y Zhao; Amanda Woodward; Audrey P Fan; Kevin T Chen; Yannan Yu; David Y Chen; Michael E Moseley; Greg Zaharchuk Journal: J Cereb Blood Flow Metab Date: 2021-11-22 Impact factor: 6.960
Authors: Melanie D Sweeney; Axel Montagne; Abhay P Sagare; Daniel A Nation; Lon S Schneider; Helena C Chui; Michael G Harrington; Judy Pa; Meng Law; Danny J J Wang; Russell E Jacobs; Fergus N Doubal; Joel Ramirez; Sandra E Black; Maiken Nedergaard; Helene Benveniste; Martin Dichgans; Costantino Iadecola; Seth Love; Philip M Bath; Hugh S Markus; Rustam Al-Shahi Salman; Stuart M Allan; Terence J Quinn; Rajesh N Kalaria; David J Werring; Roxana O Carare; Rhian M Touyz; Steve C R Williams; Michael A Moskowitz; Zvonimir S Katusic; Sarah E Lutz; Orly Lazarov; Richard D Minshall; Jalees Rehman; Thomas P Davis; Cheryl L Wellington; Hector M González; Chun Yuan; Samuel N Lockhart; Timothy M Hughes; Christopher L H Chen; Perminder Sachdev; John T O'Brien; Ingmar Skoog; Leonardo Pantoni; Deborah R Gustafson; Geert Jan Biessels; Anders Wallin; Eric E Smith; Vincent Mok; Adrian Wong; Peter Passmore; Frederick Barkof; Majon Muller; Monique M B Breteler; Gustavo C Román; Edith Hamel; Sudha Seshadri; Rebecca F Gottesman; Mark A van Buchem; Zoe Arvanitakis; Julie A Schneider; Lester R Drewes; Vladimir Hachinski; Caleb E Finch; Arthur W Toga; Joanna M Wardlaw; Berislav V Zlokovic Journal: Alzheimers Dement Date: 2019-01 Impact factor: 16.655
Authors: Renée El-Gabalawy; Ronak Patel; Kayla Kilborn; Caitlin Blaney; Christopher Hoban; Lawrence Ryner; Duane Funk; Regina Legaspi; Joseph A Fisher; James Duffin; David J Mikulis; W Alan C Mutch Journal: Front Aging Neurosci Date: 2017-08-18 Impact factor: 5.750