Andrik Rampun1, Bernie Tiddeman1, Reyer Zwiggelaar1, Paul Malcolm2. 1. Department of Computer Science, Aberystwyth University, Aberystwyth, Ceredigion SY23 3DB, United Kingdom. 2. Department of Radiology, Norfolk & Norwich University Hospital, Norwich NR4 7UY, United Kingdom.
Abstract
PURPOSE: In this paper the authors propose a texton based prostate computer aided diagnosis approach which bypasses the typical feature extraction process such as filtering and convolution which can be computationally expensive. The study focuses the peripheral zone because 75% of prostate cancers start within this region and the majority of prostate cancers arising within this region are more aggressive than those arising in the transitional zone. METHODS: For the model development, square patches were extracted at random locations from malignant and benign regions. Subsequently, extracted patches were aggregated and clustered using k-means clustering to generate textons that represent both regions. All textons together form a texton dictionary, which was used to construct a texton map for every peripheral zone in the training images. Based on the texton map, histogram models for each malignant and benign tissue samples were constructed and used as a feature vector to train our classifiers. In the testing phase, four machine learning algorithms were employed to classify each unknown sample tissue based on its corresponding feature vector. RESULTS: The proposed method was tested on 418 T2-W MR images taken from 45 patients. Evaluation results show that the best three classifiers were Bayesian network (Az = 92.8% ± 5.9%), random forest (89.5% ± 7.1%), and k-NN (86.9% ± 7.5%). These results are comparable to the state-of-the-art in the literature. CONCLUSIONS: The authors have developed a prostate computer aided diagnosis method based on textons using a single modality of T2-W MRI without the need for the typical feature extraction methods, such as filtering and convolution. The proposed method could form a solid basis for a multimodality magnetic resonance imaging based systems.
PURPOSE: In this paper the authors propose a texton based prostate computer aided diagnosis approach which bypasses the typical feature extraction process such as filtering and convolution which can be computationally expensive. The study focuses the peripheral zone because 75% of prostate cancers start within this region and the majority of prostate cancers arising within this region are more aggressive than those arising in the transitional zone. METHODS: For the model development, square patches were extracted at random locations from malignant and benign regions. Subsequently, extracted patches were aggregated and clustered using k-means clustering to generate textons that represent both regions. All textons together form a texton dictionary, which was used to construct a texton map for every peripheral zone in the training images. Based on the texton map, histogram models for each malignant and benign tissue samples were constructed and used as a feature vector to train our classifiers. In the testing phase, four machine learning algorithms were employed to classify each unknown sample tissue based on its corresponding feature vector. RESULTS: The proposed method was tested on 418 T2-W MR images taken from 45 patients. Evaluation results show that the best three classifiers were Bayesian network (Az = 92.8% ± 5.9%), random forest (89.5% ± 7.1%), and k-NN (86.9% ± 7.5%). These results are comparable to the state-of-the-art in the literature. CONCLUSIONS: The authors have developed a prostate computer aided diagnosis method based on textons using a single modality of T2-W MRI without the need for the typical feature extraction methods, such as filtering and convolution. The proposed method could form a solid basis for a multimodality magnetic resonance imaging based systems.
Authors: Ronald M Summers; Jiamin Liu; Bhavya Rehani; Phillip Stafford; Linda Brown; Adeline Louie; Duncan S Barlow; Donald W Jensen; Brooks Cash; J Richard Choi; Perry J Pickhardt; Nicholas Petrick Journal: Acad Radiol Date: 2010-06-12 Impact factor: 3.173
Authors: Duc Fehr; Harini Veeraraghavan; Andreas Wibmer; Tatsuo Gondo; Kazuhiro Matsumoto; Herbert Alberto Vargas; Evis Sala; Hedvig Hricak; Joseph O Deasy Journal: Proc Natl Acad Sci U S A Date: 2015-11-02 Impact factor: 11.205
Authors: Satish Viswanath; B Nicolas Bloch; Jonathan Chappelow; Pratik Patel; Neil Rofsky; Robert Lenkinski; Elisabeth Genega; Anant Madabhushi Journal: Proc SPIE Int Soc Opt Eng Date: 2011-03-04