Lizanne Eva van den Akker1, Heleen Beckerman2, Emma Hubertine Collette3, Isaline Catharine Josephine Maria Eijssen2, Joost Dekker4, Vincent de Groot2. 1. Department of Rehabilitation Medicine, VU University Medical Center, Amsterdam, The Netherlands; EMGO Institute for Health and Care Research, VU University Medical Center, Amsterdam, The Netherlands; MS Center Amsterdam, Amsterdam, The Netherlands. Electronic address: l.vandenakker@vumc.nl. 2. Department of Rehabilitation Medicine, VU University Medical Center, Amsterdam, The Netherlands; EMGO Institute for Health and Care Research, VU University Medical Center, Amsterdam, The Netherlands; MS Center Amsterdam, Amsterdam, The Netherlands. 3. Department of Medical Psychology, VU University Medical Center, Amsterdam, The Netherlands. 4. Department of Rehabilitation Medicine, VU University Medical Center, Amsterdam, The Netherlands; EMGO Institute for Health and Care Research, VU University Medical Center, Amsterdam, The Netherlands; Department of Psychiatry, VU University Medical Center, Amsterdam, The Netherlands.
Abstract
BACKGROUND: Fatigue is a frequently occurring symptom of multiple sclerosis (MS) that limits social participation. OBJECTIVE: To systematically determine the short and long-term effects of cognitive behavioral therapy (CBT) for the treatment of MS-related fatigue. DATA SOURCES: Pubmed, Cochrane, EMBASE, Psychology and Behavioral Sciences Collection, ERIC, PsychINFO, Cinahl, PsycARTICLES, and relevant trial registers were searched up to February 2016. In addition, references from retrieved articles were examined. STUDY SELECTION: Studies were included if participants had MS, fatigue was a primary outcome measure, the intervention was CBT, and the design was a randomized controlled trial. The search was performed by two independent reviewers, three CBT experts determined whether interventions were CBT. DATA EXTRACTION: Data on patient and study characteristics and fatigue were systematically extracted using a standardized data extraction form. Two independent reviewers assessed risk of bias using the Cochrane Collaboration risk of bias tool. In the event of disagreement, a third reviewer was consulted. DATA SYNTHESIS: Of the 994 identified studies, 4 studies were included in the meta-analysis, comprising 193 CBT-treated patients and 210 patients who underwent a control treatment. Meta-analyses of these studies showed that CBT treatment had a positive short-term effect on fatigue (standardized mean difference [SMD]=-0.47; 95% confidence interval [CI]=-0.88; -0.06; I2=73%). In addition, three studies showed a long-term positive effect of CBT (SMD=-0.30; CI -0.51; -0.08; I2=0%). CONCLUSIONS: This review found that the use of CBT for the treatment of fatigue in patients with MS has a moderately positive short-term effect. However, this effect decreases with cessation of treatment.
BACKGROUND:Fatigue is a frequently occurring symptom of multiple sclerosis (MS) that limits social participation. OBJECTIVE: To systematically determine the short and long-term effects of cognitive behavioral therapy (CBT) for the treatment of MS-related fatigue. DATA SOURCES: Pubmed, Cochrane, EMBASE, Psychology and Behavioral Sciences Collection, ERIC, PsychINFO, Cinahl, PsycARTICLES, and relevant trial registers were searched up to February 2016. In addition, references from retrieved articles were examined. STUDY SELECTION: Studies were included if participants had MS, fatigue was a primary outcome measure, the intervention was CBT, and the design was a randomized controlled trial. The search was performed by two independent reviewers, three CBT experts determined whether interventions were CBT. DATA EXTRACTION: Data on patient and study characteristics and fatigue were systematically extracted using a standardized data extraction form. Two independent reviewers assessed risk of bias using the Cochrane Collaboration risk of bias tool. In the event of disagreement, a third reviewer was consulted. DATA SYNTHESIS: Of the 994 identified studies, 4 studies were included in the meta-analysis, comprising 193 CBT-treated patients and 210 patients who underwent a control treatment. Meta-analyses of these studies showed that CBT treatment had a positive short-term effect on fatigue (standardized mean difference [SMD]=-0.47; 95% confidence interval [CI]=-0.88; -0.06; I2=73%). In addition, three studies showed a long-term positive effect of CBT (SMD=-0.30; CI -0.51; -0.08; I2=0%). CONCLUSIONS: This review found that the use of CBT for the treatment of fatigue in patients with MS has a moderately positive short-term effect. However, this effect decreases with cessation of treatment.
Authors: Sarah D Broicher; Linard Filli; Olivia Geisseler; Nicole Germann; Björn Zörner; P Brugger; M Linnebank Journal: J Neurol Date: 2018-02-20 Impact factor: 4.849
Authors: Anne Arewasikporn; Aaron P Turner; Kevin N Alschuler; Abbey J Hughes; Dawn M Ehde Journal: Health Psychol Date: 2018-04-19 Impact factor: 4.267
Authors: Maria-Eleni Roumelioti; Jennifer L Steel; Jonathan Yabes; Kevin E Vowles; Yoram Vodovotz; Scott Beach; Bruce Rollman; Steven D Weisbord; Mark L Unruh; Manisha Jhamb Journal: Contemp Clin Trials Date: 2018-09-09 Impact factor: 2.226
Authors: Annalisa Sgoifo; Angelo Bignamini; Loredana La Mantia; Maria G Celani; Piero Parietti; Maria A Ceriani; Maria R Marazzi; Paola Proserpio; Lino Nobili; Alessandra Protti; Elio C Agostoni Journal: Neurol Ther Date: 2017-08-09
Authors: Federica Picariello; Rona Moss-Morris; Iain C Macdougall; Sam Norton; Maria Da Silva-Gane; Ken Farrington; Hope Clayton; Joseph Chilcot Journal: BMJ Open Date: 2018-03-08 Impact factor: 2.692
Authors: Kirsten Van Kessel; Duncan R Babbage; Nicholas Reay; Warren M Miner-Williams; Paula Kersten Journal: JMIR Mhealth Uhealth Date: 2017-02-28 Impact factor: 4.773