Bharat Thyagarajan1, Annie Green Howard2, Ramon Durazo-Arvizu3, John H Eckfeldt4, Marc D Gellman5, Ryung S Kim6, Kiang Liu7, Armando J Mendez5, Frank J Penedo7, Gregory A Talavera8, Marston E Youngblood2, Lihui Zhao7, Daniela Sotres-Alvarez2. 1. Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN, United States. Electronic address: thya0003@umn.edu. 2. Collaborative Studies Coordinating Center, Department of Biostatistics, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, United States. 3. Department of Public Health Sciences, Division of Biostatistics, Loyola University Chicago, Maywood, IL, United States. 4. Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN, United States. 5. Department of Psychology, Behavioral Medicine Research Center, University of Miami, Miami, FL, United States. 6. Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY, United States. 7. Department of Preventive Medicine, Northwestern University, Chicago, IL, United States. 8. Institute for Behavioral and Community Health, Graduate School of Public Health, San Diego State University, San Diego, CA, United States.
Abstract
BACKGROUND: Biomarker variability, which includes within-individual variability (CVI), between-individual variability (CVG) and methodological variability (CVP+A) is an important determinant of our ability to detect biomarker-disease associations. Estimates of CVI and CVG may be population specific and little data exists on biomarker variability in diverse Hispanic populations. Hence, we evaluated all 3 components of biomarker variability in the Hispanic Community Health Study/Study of Latinos (HCHS/SOL) using repeat blood collections (n=58) and duplicate blood measurements (n=761-929 depending on the biomarker). METHODS: We estimated the index of individuality (II) ((CVI+CVP+A)/CVG) for 41 analytes and evaluated differences in the II across sexes and age groups. RESULTS: Biomarkers such as fasting glucose, triglycerides and ferritin had substantially higher inter-individual variability and lower II in HCHS/SOL as compared to the published literature. We also found significant sex-specific differences in the II for neutrophil count, platelet count, hemoglobin, % eosinophils and fasting glucose. The II for fasting insulin, post oral glucose tolerance test glucose and cystatin C was significantly higher among the 18-44y age group as compared to the 45+y age group. CONCLUSIONS: The implications of these findings for determining biomarker-disease associations in Hispanic populations need to be evaluated in future studies. Copyright Â
BACKGROUND: Biomarker variability, which includes within-individual variability (CVI), between-individual variability (CVG) and methodological variability (CVP+A) is an important determinant of our ability to detect biomarker-disease associations. Estimates of CVI and CVG may be population specific and little data exists on biomarker variability in diverse Hispanic populations. Hence, we evaluated all 3 components of biomarker variability in the Hispanic Community Health Study/Study of Latinos (HCHS/SOL) using repeat blood collections (n=58) and duplicate blood measurements (n=761-929 depending on the biomarker). METHODS: We estimated the index of individuality (II) ((CVI+CVP+A)/CVG) for 41 analytes and evaluated differences in the II across sexes and age groups. RESULTS: Biomarkers such as fasting glucose, triglycerides and ferritin had substantially higher inter-individual variability and lower II in HCHS/SOL as compared to the published literature. We also found significant sex-specific differences in the II for neutrophil count, platelet count, hemoglobin, % eosinophils and fasting glucose. The II for fasting insulin, post oral glucose tolerance test glucose and cystatin C was significantly higher among the 18-44y age group as compared to the 45+y age group. CONCLUSIONS: The implications of these findings for determining biomarker-disease associations in Hispanic populations need to be evaluated in future studies. Copyright Â
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