BACKGROUND: Numerical data on the components of biological variation (BV) have many uses in laboratory medicine, including in the setting of analytical quality specifications, generation of reference change values and assessment of the utility of conventional reference values. METHODS: Generation of a series of up-to-date comprehensive database of components of BV was initiated in 1997, integrating the more relevant information found in publications concerning BV. A scoring system was designed to evaluate the robustness of the data included. The database has been updated every 2 years, made available on the Internet and derived analytical quality specifications for imprecision, bias and total allowable error included in the tabulation of data. RESULTS AND CONCLUSIONS: Our aim here is to document, in detail, the methodology we used to evaluate the reliability of the included data compiled from the published literature. To date, our approach has not been explicitly documented, although the principles have been presented at many symposia, courses and conferences.
BACKGROUND: Numerical data on the components of biological variation (BV) have many uses in laboratory medicine, including in the setting of analytical quality specifications, generation of reference change values and assessment of the utility of conventional reference values. METHODS: Generation of a series of up-to-date comprehensive database of components of BV was initiated in 1997, integrating the more relevant information found in publications concerning BV. A scoring system was designed to evaluate the robustness of the data included. The database has been updated every 2 years, made available on the Internet and derived analytical quality specifications for imprecision, bias and total allowable error included in the tabulation of data. RESULTS AND CONCLUSIONS: Our aim here is to document, in detail, the methodology we used to evaluate the reliability of the included data compiled from the published literature. To date, our approach has not been explicitly documented, although the principles have been presented at many symposia, courses and conferences.
Authors: Clark M Henderson; James G Bollinger; Jessica O Becker; Jennifer M Wallace; Thomas J Laha; Michael J MacCoss; Andrew N Hoofnagle Journal: Proteomics Clin Appl Date: 2017-03-06 Impact factor: 3.494
Authors: Michela Bottani; Giuseppe Banfi; Elena Guerra; Massimo Locatelli; Aasne K Aarsand; Abdurrahman Coşkun; Jorge Díaz-Garzón; Pilar Fernandez-Calle; Sverre Sandberg; Ferruccio Ceriotti; Elisabet González-Lao; Margarita Simon; Anna Carobene Journal: Ann Transl Med Date: 2020-07
Authors: Bharat Thyagarajan; Annie Green Howard; Ramon Durazo-Arvizu; John H Eckfeldt; Marc D Gellman; Ryung S Kim; Kiang Liu; Armando J Mendez; Frank J Penedo; Gregory A Talavera; Marston E Youngblood; Lihui Zhao; Daniela Sotres-Alvarez Journal: Clin Chim Acta Date: 2016-10-15 Impact factor: 3.786