| Literature DB >> 27753026 |
Eva Pazourkova1, Sarka Pospisilova2, Iveta Svobodova2, Ales Horinek2,3, Antonin Brisuda4, Viktor Soukup5, Jan Hrbacek4, Otakar Capoun5, Jaroslav Mares3, Tomas Hanus5, Marek Babjuk4, Marie Korabecna6.
Abstract
MicroRNAs (miRNAs) in urine are examined as potential biomarkers. We examined the urine samples from 70 individuals (45 males, 25 females, mean age 65 years, range 20-84 years). Of the urine donors, 15 were healthy volunteers, 5 were patients with non-cancer diseases, 50 were patients with different stages of bladder cancer. To examine the spectrum of miRNAs in the cell-free fraction of urine, TaqMan Human miRNA Array Card A v.2.1 was used. A set of 30 miRNAs were found that are constantly present in urine supernatants independently of sex, age and health status of the subjects. We compared this set with miRNAs found in plasma, expressed in kidney and genito-urinary tract. Our results indicate that some miRNA could be transferred from the circulation into urine.Entities:
Keywords: Genito-urinary tract; MicroRNA; Plasma; Transrenal passage of microRNAs; Urine supernatant
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Year: 2016 PMID： 27753026 DOI： 10.1007/978-3-319-42044-8_18
Source DB: PubMed Journal: Adv Exp Med Biol ISSN： 0065-2598 Impact factor: 2.622