Literature DB >> 27752804

Interaction of hemin with quadruplex DNA.

Maryam Ghahremani Nasab1, Leila Hassani2, Sara Mohammadi Nejad1, Davood Norouzi3.   

Abstract

A DNA enzyme with peroxidase activity is a G-quadruplex-based DNAzyme formed by hemin and G-quadruplex DNA. Activity of peroxide DNAzymes can be influenced by the structure of quadruplex DNA. In this investigation, the interaction of hemin with T30695 G-quadruplex DNA is evaluated. Molecular dynamic simulation indicates that the binding mode of hemin to G-quadruplex DNA is end-stacking, which is consistent with absorption spectroscopy. Based on fluorescence spectroscopy, hemin ejects thiazole orange from bases of four-strand DNA. Circular dichroism spectra showed that no alteration occurs in this type of DNA structure. Graphical Abstract Peroxidase DNAzyme is formed by hemin and G-quadruplex DNA.

Entities:  

Keywords:  DNAzyme; Hemin; Interaction; Peroxidase; Quadruplex

Mesh：

Substances：

Year:  2016        PMID： 27752804      PMCID： PMC5323342          DOI： 10.1007/s10867-016-9430-7

Source DB:  PubMed          Journal:  J Biol Phys        ISSN： 0092-0606            Impact factor:   1.365


  25 in total

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Review 2.  Circular dichroism and guanine quadruplexes.

Authors:  Michaela Vorlíčková; Iva Kejnovská; Janos Sagi; Daniel Renčiuk; Klára Bednářová; Jitka Motlová; Jaroslav Kypr
Journal:  Methods       Date:  2012-03-17       Impact factor: 3.608

3.  Fluorescence detection of lead(II) ions through their induced catalytic activity of DNAzymes.

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Journal:  Anal Chem       Date:  2010-12-09       Impact factor: 6.986

Review 4.  How to study proteins by circular dichroism.

Authors:  Sharon M Kelly; Thomas J Jess; Nicholas C Price
Journal:  Biochim Biophys Acta       Date:  2005-08-10

5.  Chemiluminescence and chemiluminescence resonance energy transfer (CRET) aptamer sensors using catalytic hemin/G-quadruplexes.

Authors:  Xiaoqing Liu; Ronit Freeman; Eyal Golub; Itamar Willner
Journal:  ACS Nano       Date:  2011-09-08       Impact factor: 15.881

6.  Development of a fluorescent intercalator displacement assay (G4-FID) for establishing quadruplex-DNA affinity and selectivity of putative ligands.

Authors:  David Monchaud; Clémence Allain; Marie-Paule Teulade-Fichou
Journal:  Bioorg Med Chem Lett       Date:  2006-07-11       Impact factor: 2.823

7.  DNA-binding and cleavage studies of macrocyclic copper(II) complexes.

Authors:  Jie Liu; Tixiang Zhang; Tongbu Lu; Lianghu Qu; Hui Zhou; Qianling Zhang; Liangnian Ji
Journal:  J Inorg Biochem       Date:  2002-07-25       Impact factor: 4.155

8.  Lead(II)-induced allosteric G-quadruplex DNAzyme as a colorimetric and chemiluminescence sensor for highly sensitive and selective Pb2+ detection.

Authors:  Tao Li; Erkang Wang; Shaojun Dong
Journal:  Anal Chem       Date:  2010-02-15       Impact factor: 6.986

9.  Interactions of porphyrins with nucleic acids.

Authors:  R F Pasternack; E J Gibbs; J J Villafranca
Journal:  Biochemistry       Date:  1983-05-10       Impact factor: 3.162

10.  Specific high-affinity binding of thiazole orange to triplex and G-quadruplex DNA.

Authors:  Irit Lubitz; Dragoslav Zikich; Alexander Kotlyar
Journal:  Biochemistry       Date:  2010-05-04       Impact factor: 3.162
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  5 in total

1.  Berberrubine Phosphate: A Selective Fluorescent Probe for Quadruplex DNA.

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2.  Carbon dot mediated G quadruplex nano-network formation for enhanced DNAzyme activity and easy catalyst reclamation.

Authors:  Sonam Kumari; Saptarshi Mandal; Prolay Das
Journal:  RSC Adv       Date:  2019-12-17       Impact factor: 3.361

3.  CGG repeat RNA G-quadruplexes interact with FMRpolyG to cause neuronal dysfunction in fragile X-related tremor/ataxia syndrome.

Authors:  Sefan Asamitsu; Yasushi Yabuki; Susumu Ikenoshita; Kosuke Kawakubo; Moe Kawasaki; Shingo Usuki; Yuji Nakayama; Kaori Adachi; Hiroyuki Kugoh; Kazuhiro Ishii; Tohru Matsuura; Eiji Nanba; Hiroshi Sugiyama; Kohji Fukunaga; Norifumi Shioda
Journal:  Sci Adv       Date:  2021-01-13       Impact factor: 14.136

4.  Investigation and improvement of catalytic activity of G-quadruplex/hemin DNAzymes using designed terminal G-tetrads with deoxyadenosine caps.

Authors:  Yanwei Cao; Pi Ding; Luyan Yang; Wenjing Li; Yu Luo; Jine Wang; Renjun Pei
Journal:  Chem Sci       Date:  2020-06-17       Impact factor: 9.825

Review 5.  One ring to bring them all and in the darkness bind them: The trafficking of heme without deliverers.

Authors:  Ian G Chambers; Mathilda M Willoughby; Iqbal Hamza; Amit R Reddi
Journal:  Biochim Biophys Acta Mol Cell Res       Date:  2020-10-03       Impact factor: 4.739
  5 in total

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