Literature DB >> 27748753

Structural basis of nonribosomal peptide macrocyclization in fungi.

Nicholas Liu1, Ralph A Cacho1, Jinru Zhang2, Zhou Gong3, Zhu Liu4, Wenming Qin5, Chun Tang3,4, Yi Tang1, Jiahai Zhou2,6.   

Abstract

Nonribosomal peptide synthetases (NRPSs) in fungi biosynthesize important pharmaceutical compounds, including penicillin, cyclosporine and echinocandin. To understand the fungal strategy of forging the macrocyclic peptide linkage, we determined the crystal structures of the terminal condensation-like (CT) domain and the holo thiolation (T)-CT complex of Penicillium aethiopicum TqaA. The first, to our knowledge, structural depiction of the terminal module in a fungal NRPS provides a molecular blueprint for generating new macrocyclic peptide natural products.

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Year:  2016        PMID： 27748753      PMCID： PMC5110376          DOI： 10.1038/nchembio.2202

Source DB:  PubMed          Journal:  Nat Chem Biol        ISSN： 1552-4450            Impact factor:   15.040


  30 in total

1.  The structure of VibH represents nonribosomal peptide synthetase condensation, cyclization and epimerization domains.

Authors:  Thomas A Keating; C Gary Marshall; Christopher T Walsh; Amy E Keating
Journal:  Nat Struct Biol       Date:  2002-07

2.  Expression, crystallization and preliminary X-ray analysis of an anomeric inverting agarase from Pseudoalteromonas sp. CY24.

Authors:  Aiming Ren; Zong-Xiang Xia; Wengong Yu; Jiahai Zhou
Journal:  Acta Crystallogr Sect F Struct Biol Cryst Commun       Date:  2010-11-26

Review 3.  Assembly-line enzymology for polyketide and nonribosomal Peptide antibiotics: logic, machinery, and mechanisms.

Authors:  Michael A Fischbach; Christopher T Walsh
Journal:  Chem Rev       Date:  2006-08       Impact factor: 60.622

4.  Toward rational protein crystallization: A Web server for the design of crystallizable protein variants.

Authors:  Lukasz Goldschmidt; David R Cooper; Zygmunt S Derewenda; David Eisenberg
Journal:  Protein Sci       Date:  2007-08       Impact factor: 6.725

5.  Crystal structures of the first condensation domain of CDA synthetase suggest conformational changes during the synthetic cycle of nonribosomal peptide synthetases.

Authors:  Kristjan Bloudoff; Dmitry Rodionov; T Martin Schmeing
Journal:  J Mol Biol       Date:  2013-06-10       Impact factor: 5.469

6.  Assembly of asperlicin peptidyl alkaloids from anthranilate and tryptophan: a two-enzyme pathway generates heptacyclic scaffold complexity in asperlicin E.

Authors:  Stuart W Haynes; Xue Gao; Yi Tang; Christopher T Walsh
Journal:  J Am Chem Soc       Date:  2012-10-09       Impact factor: 15.419

7.  Features and development of Coot.

Authors:  P Emsley; B Lohkamp; W G Scott; K Cowtan
Journal:  Acta Crystallogr D Biol Crystallogr       Date:  2010-03-24

8.  Hijacking a hydroxyethyl unit from a central metabolic ketose into a nonribosomal peptide assembly line.

Authors:  Chao Peng; Jin-Yue Pu; Li-Qiang Song; Xiao-Hong Jian; Man-Cheng Tang; Gong-Li Tang
Journal:  Proc Natl Acad Sci U S A       Date:  2012-05-14       Impact factor: 11.205

9.  MolProbity: all-atom structure validation for macromolecular crystallography.

Authors:  Vincent B Chen; W Bryan Arendall; Jeffrey J Headd; Daniel A Keedy; Robert M Immormino; Gary J Kapral; Laura W Murray; Jane S Richardson; David C Richardson
Journal:  Acta Crystallogr D Biol Crystallogr       Date:  2009-12-21

10.  Phaser crystallographic software.

Authors:  Airlie J McCoy; Ralf W Grosse-Kunstleve; Paul D Adams; Martyn D Winn; Laurent C Storoni; Randy J Read
Journal:  J Appl Crystallogr       Date:  2007-07-13       Impact factor: 3.304
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  22 in total

Review 1.  Refining and expanding nonribosomal peptide synthetase function and mechanism.

Authors:  Matt McErlean; Jonathan Overbay; Steven Van Lanen
Journal:  J Ind Microbiol Biotechnol       Date:  2019-01-23       Impact factor: 3.346

2.  Biosynthetic Cyclization Catalysts for the Assembly of Peptide and Polyketide Natural Products.

Authors:  Maria L Adrover-Castellano; Jennifer J Schmidt; David H Sherman
Journal:  ChemCatChem       Date:  2021-01-28       Impact factor: 5.686

Review 3.  Biosynthesis of depsipeptides, or Depsi: The peptides with varied generations.

Authors:  Diego A Alonzo; T Martin Schmeing
Journal:  Protein Sci       Date:  2020-11-02       Impact factor: 6.725

Review 4.  Diversity of Linear Non-Ribosomal Peptide in Biocontrol Fungi.

Authors:  Xiaoyan Niu; Narit Thaochan; Qiongbo Hu
Journal:  J Fungi (Basel)       Date:  2020-05-12

5.  The modules of trans-acyltransferase assembly lines redefined with a central acyl carrier protein.

Authors:  Drew A Vander Wood; Adrian T Keatinge-Clay
Journal:  Proteins       Date:  2018-03-25

6.  Structural Insights into the Free-Standing Condensation Enzyme SgcC5 Catalyzing Ester-Bond Formation in the Biosynthesis of the Enediyne Antitumor Antibiotic C-1027.

Authors:  Chin-Yuan Chang; Jeremy R Lohman; Tingting Huang; Karolina Michalska; Lance Bigelow; Jeffrey D Rudolf; Robert Jedrzejczak; Xiaohui Yan; Ming Ma; Gyorgy Babnigg; Andrzej Joachimiak; George N Phillips; Ben Shen
Journal:  Biochemistry       Date:  2018-03-21       Impact factor: 3.162

7.  Interrogation of Benzomalvin Biosynthesis Using Fungal Artificial Chromosomes with Metabolomic Scoring (FAC-MS): Discovery of a Benzodiazepine Synthase Activity.

Authors:  Kenneth D Clevenger; Rosa Ye; Jin Woo Bok; Paul M Thomas; Md Nurul Islam; Galen P Miley; Matthew T Robey; Cynthia Chen; KaHoua Yang; Michael Swyers; Edward Wu; Peng Gao; Chengcang C Wu; Nancy P Keller; Neil L Kelleher
Journal:  Biochemistry       Date:  2018-03-20       Impact factor: 3.162

Review 8.  Nonribosomal peptide synthetase biosynthetic clusters of ESKAPE pathogens.

Authors:  Andrew M Gulick
Journal:  Nat Prod Rep       Date:  2017-08-02       Impact factor: 13.423

9.  Chemometrics and genome mining reveal an unprecedented family of sugar acid-containing fungal nonribosomal cyclodepsipeptides.

Authors:  Chen Wang; Dongliang Xiao; Baoqing Dun; Miaomiao Yin; Adigo Setargie Tsega; Linan Xie; Wenhua Li; Qun Yue; Sibao Wang; Han Gao; Min Lin; Liwen Zhang; István Molnár; Yuquan Xu
Journal:  Proc Natl Acad Sci U S A       Date:  2022-08-01       Impact factor: 12.779

Review 10.  Trapping interactions between catalytic domains and carrier proteins of modular biosynthetic enzymes with chemical probes.

Authors:  Andrew M Gulick; Courtney C Aldrich
Journal:  Nat Prod Rep       Date:  2018-11-14       Impact factor: 13.423
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