Yoshihiro Miyake1,2, Keiko Tanaka3,4, Hitomi Okubo5, Satoshi Sasaki6, Shinya Furukawa3,4, Masashi Arakawa7. 1. Department of Epidemiology and Preventive Medicine, Ehime University Graduate School of Medicine, Ehime, 791-0295, Japan. miyake.yoshihiro.ls@ehime-u.ac.jp. 2. Epidemiology and Medical Statistics Unit, Translational Research Center, Ehime University Hospital, Ehime, Japan. miyake.yoshihiro.ls@ehime-u.ac.jp. 3. Department of Epidemiology and Preventive Medicine, Ehime University Graduate School of Medicine, Ehime, 791-0295, Japan. 4. Epidemiology and Medical Statistics Unit, Translational Research Center, Ehime University Hospital, Ehime, Japan. 5. Department of Health Promotion, National Institute of Public Health, Saitama, Japan. 6. Department of Social and Preventive Epidemiology, School of Public Health, The University of Tokyo, Tokyo, Japan. 7. Health Tourism Research Fields, Graduate School of Tourism Sciences, University of the Ryukyus, Okinawa, Japan.
Abstract
OBJECTIVE: Several observational studies and trials examined the relationship between isoflavones or soybeans and depressive symptoms among peri- and postmenopausal women. We cross-sectionally evaluated the associations between intake of soy products and isoflavones and depressive symptoms during pregnancy in Japan. METHODS: Study subjects were 1745 pregnant women. Dietary intake during the preceding month was assessed using a self-administered diet history questionnaire. Depressive symptoms were defined by a score of 16 or over in the Center for Epidemiologic Studies Depression Scale. RESULTS: Higher intake of total soy products, tofu, tofu products, fermented soybeans, boiled soybeans, miso soup, and isoflavones was independently related to a lower prevalence of depressive symptoms during pregnancy: The adjusted prevalence ratios (95 % confidence intervals, P for trend) between extreme quartiles were 0.63 (0.47-0.85, 0.002), 0.72 (0.54-0.96, 0.007), 0.74 (0.56-0.98, 0.04), 0.57 (0.42-0.76, <0.0001), 0.73 (0.55-0.98, 0.03), 0.65 (0.49-0.87, 0.003), and 0.63 (0.46-0.86, 0.002), respectively. A significant positive exposure-response relationship was found between miso intake and depressive symptoms during pregnancy. No material relationship was observed between soymilk intake and depressive symptoms during pregnancy. CONCLUSIONS: Our study is the first to show independent inverse relationships between intake of total soy products, tofu, tofu products, fermented soybeans, boiled soybeans, miso soup, and isoflavones and depressive symptoms during pregnancy.
OBJECTIVE: Several observational studies and trials examined the relationship between isoflavones or soybeans and depressive symptoms among peri- and postmenopausal women. We cross-sectionally evaluated the associations between intake of soy products and isoflavones and depressive symptoms during pregnancy in Japan. METHODS: Study subjects were 1745 pregnant women. Dietary intake during the preceding month was assessed using a self-administered diet history questionnaire. Depressive symptoms were defined by a score of 16 or over in the Center for Epidemiologic Studies Depression Scale. RESULTS: Higher intake of total soy products, tofu, tofu products, fermented soybeans, boiled soybeans, miso soup, and isoflavones was independently related to a lower prevalence of depressive symptoms during pregnancy: The adjusted prevalence ratios (95 % confidence intervals, P for trend) between extreme quartiles were 0.63 (0.47-0.85, 0.002), 0.72 (0.54-0.96, 0.007), 0.74 (0.56-0.98, 0.04), 0.57 (0.42-0.76, <0.0001), 0.73 (0.55-0.98, 0.03), 0.65 (0.49-0.87, 0.003), and 0.63 (0.46-0.86, 0.002), respectively. A significant positive exposure-response relationship was found between miso intake and depressive symptoms during pregnancy. No material relationship was observed between soymilk intake and depressive symptoms during pregnancy. CONCLUSIONS: Our study is the first to show independent inverse relationships between intake of total soy products, tofu, tofu products, fermented soybeans, boiled soybeans, miso soup, and isoflavones and depressive symptoms during pregnancy.
Authors: S Sasaki; F Ushio; K Amano; M Morihara; O Todoriki; Y Uehara; E Toyooka Journal: J Nutr Sci Vitaminol (Tokyo) Date: 2000-12 Impact factor: 2.000