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Literature DB >> 27741966

The Role of Opioid Analgesics in Geriatric Pain Management.

Jennifer Greene Naples¹, Walid F Gellad², Joseph T Hanlon³.

Abstract

When possible, chronic noncancer pain (CNCP) in older adults should be managed by nonpharmacologic modalities in conjunction with nonopioid analgesics. If moderate-to-severe pain persists despite these approaches, however, nonparenteral opioids may be considered as adjunctive therapy. This article reviews the epidemiology of opioid use and their effectiveness for CNCP in older adults and summarizes important age-related changes in opioid pharmacokinetics and pharmacodynamics that increase the risks of adverse effects in the elderly. Finally, to assist clinicians with selecting appropriate therapy, the article concludes with an evidence-based approach to optimize opioid prescribing in older adults with CNCP.

Entities: Chemical Disease Gene Species

Keywords: Adverse drug event; Aged; Opioid; Pharmacokinetics

Mesh：

Substances：
Analgesics, Opioid

Year: 2016 PMID： 27741966 PMCID： PMC5139620 DOI： 10.1016/j.cger.2016.06.006

Source DB: PubMed Journal: Clin Geriatr Med ISSN： 0749-0690 Impact factor: 3.076

48 in total

1. American Geriatrics Society 2015 Updated Beers Criteria for Potentially Inappropriate Medication Use in Older Adults.

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Review 3. Clinical pharmacology of analgesic medicines in older people: impact of frailty and cognitive impairment.

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Journal: J Am Geriatr Soc Date: 2011-08-08 Impact factor: 5.562

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7. Opioid analgesics and the risk of fractures in older adults with arthritis.

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Journal: J Am Geriatr Soc Date: 2011-03 Impact factor: 5.562

8. Pharmacologic management of non-cancer pain among nursing home residents.

Authors: Kate L Lapane; Brian J Quilliam; Wing Chow; Myoung S Kim
Journal: J Pain Symptom Manage Date: 2012-07-26 Impact factor: 3.612

9. Drug-poisoning Deaths Involving Opioid Analgesics: United States, 1999-2011.

Authors: Li Hui Chen; Holly Hedegaard; Margaret Warner
Journal: NCHS Data Brief Date: 2014-09

10. Number and dosage of central nervous system medications on recurrent falls in community elders: the Health, Aging and Body Composition study.

Authors: Joseph T Hanlon; Robert M Boudreau; Yazan F Roumani; Anne B Newman; Christine M Ruby; Rollin M Wright; Sarah N Hilmer; Ronald I Shorr; Douglas C Bauer; Eleanor M Simonsick; Stephanie A Studenski
Journal: J Gerontol A Biol Sci Med Sci Date: 2009-02-04 Impact factor: 6.053

30 in total

Review 1. Opioid Management in Older Adults with Chronic Kidney Disease: A Review.

Authors: Montgomery T Owsiany; Chelsea E Hawley; Laura K Triantafylidis; Julie M Paik
Journal: Am J Med Date: 2019-07-08 Impact factor: 4.965

Review 2. New directions in the treatment of opioid withdrawal.

Authors: A Benjamin Srivastava; John J Mariani; Frances R Levin
Journal: Lancet Date: 2020-06-20 Impact factor: 79.321

3. Opioid Exposure Negatively Affects Antidepressant Response to Venlafaxine in Older Adults with Chronic Low Back Pain and Depression.

Authors: Sarah T Stahl; Changgi Jung; Debra K Weiner; Marta Peciña; Jordan F Karp
Journal: Pain Med Date: 2020-08-01 Impact factor: 3.750

4. New persistent opioid use among older patients following surgery: A Medicare claims analysis.

Authors: Katherine B Santosa; Hsou-Mei Hu; Chad M Brummett; Margaret A Olsen; Michael J Englesbe; Eva A Williams; Jennifer F Waljee
Journal: Surgery Date: 2019-07-23 Impact factor: 3.982

5. Higher Amounts of Opioids Filled After Surgery Increase Risk of Serious Falls and Fall-Related Injuries Among Older Adults.

Authors: Katherine B Santosa; Yen-Ling Lai; Chad M Brummett; Jeremie D Oliver; Hsou-Mei Hu; Michael J Englesbe; Emilie M Blair; Jennifer F Waljee
Journal: J Gen Intern Med Date: 2020-08-03 Impact factor: 5.128

6. Risk of Fractures in Older Adults with Chronic Non-cancer Pain Receiving Concurrent Benzodiazepines and Opioids: A Nested Case-Control Study.

Authors: Ye-Jin Kang; Min-Taek Lee; Myo-Song Kim; Seung-Hun You; Jae-Eun Lee; Joo-Hyeon Eom; Sun-Young Jung
Journal: Drugs Aging Date: 2021-06-23 Impact factor: 3.923