Literature DB >> 27717176

Local Delivery of PHD2 siRNA from ROS-Degradable Scaffolds to Promote Diabetic Wound Healing.

John R Martin1, Christopher E Nelson1, Mukesh K Gupta1, Fang Yu2, Samantha M Sarett1, Kyle M Hocking1, Alonda C Pollins3, Lillian B Nanney3, Jeffrey M Davidson2,4, Scott A Guelcher5, Craig L Duvall1.   

Abstract

Small interfering RNA (siRNA) delivered from reactive oxygen species-degradable tissue engineering scaffolds promotes diabetic wound healing in rats. Porous poly(thioketal-urethane) scaffolds implanted in diabetic wounds locally deliver siRNA that inhibits the expression of prolyl hydroxylase domain protein 2, thereby increasing the expression of progrowth genes and increasing vasculature, proliferating cells, and tissue development in diabetic wounds.
© 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Entities:  

Keywords:  diabetes; reactive oxygen species; scaffolds; siRNA; wound healing

Mesh：

Substances：

Year:  2016        PMID： 27717176      PMCID： PMC5152672          DOI： 10.1002/adhm.201600820

Source DB:  PubMed          Journal:  Adv Healthc Mater        ISSN： 2192-2640            Impact factor:   9.933


  57 in total

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Authors:  A C Epstein; J M Gleadle; L A McNeill; K S Hewitson; J O'Rourke; D R Mole; M Mukherji; E Metzen; M I Wilson; A Dhanda; Y M Tian; N Masson; D L Hamilton; P Jaakkola; R Barstead; J Hodgkin; P H Maxwell; C W Pugh; C J Schofield; P J Ratcliffe
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8.  HIF prolyl-hydroxylase 2 is the key oxygen sensor setting low steady-state levels of HIF-1alpha in normoxia.

Authors:  Edurne Berra; Emmanuel Benizri; Amandine Ginouvès; Véronique Volmat; Danièle Roux; Jacques Pouysségur
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  22 in total

1.  Poly(Thioketal Urethane) Autograft Extenders in an Intertransverse Process Model of Bone Formation.

Authors:  Madison A P McGough; Stefanie M Shiels; Lauren A Boller; Katarzyna J Zienkiewicz; Craig L Duvall; Joseph C Wenke; Scott A Guelcher
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Review 6.  Macrophages as a therapeutic target to promote diabetic wound healing.

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