Literature DB >> 2771642

Uncharged stereoregular nucleic acid analogs: 2. Morpholino nucleoside oligomers with carbamate internucleoside linkages.

E P Stirchak1, J E Summerton, D D Weller.   

Abstract

A novel oligonucleotide analog has been prepared from ribonucleoside derived morpholine subunits linked by carbamate groups. Oxidative cleavage of the 2',3' vicinal diol of cytidine followed by reductive amination of the resulting dialdehyde afforded the morpholine subunit. Coupling of the subunits are through carbamate moieties and the oligomers were characterized by 1H NMR and FAB MS. Evidence for interaction of the hexamer 19 with p(dG6) was found, but an atypical interaction of 19 with a RNA target was observed.

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Year:  1989        PMID： 2771642      PMCID： PMC318266          DOI： 10.1093/nar/17.15.6129

Source DB:  PubMed          Journal:  Nucleic Acids Res        ISSN： 0305-1048            Impact factor:   16.971


  5 in total

Review 1.  Modulation of eukaryotic gene expression by complementary RNA or DNA sequences.

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Journal:  Biotechniques       Date:  1988 Nov-Dec       Impact factor: 1.993

2.  Control of ribonucleic acid function by oligonucleoside methylphosphonates.

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3.  Effects of pendant groups at phosphorus on binding properties of d-ApA analogues.

Authors:  R L Letsinger; S A Bach; J S Eadie
Journal:  Nucleic Acids Res       Date:  1986-04-25       Impact factor: 16.971

4.  Comparative hybrid arrest by tandem antisense oligodeoxyribonucleotides or oligodeoxyribonucleoside methylphosphonates in a cell-free system.

Authors:  L J Maher; B J Dolnick
Journal:  Nucleic Acids Res       Date:  1988-04-25       Impact factor: 16.971

5.  (Acyloxy)alkyl carbamates as novel bioreversible prodrugs for amines: increased permeation through biological membranes.

Authors:  J Alexander; R Cargill; S R Michelson; H Schwam
Journal:  J Med Chem       Date:  1988-02       Impact factor: 7.446
  5 in total
  21 in total

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Review 2.  Strategies, design, and chemistry in siRNA delivery systems.

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Review 3.  Strategy for designing specific antisense oligonucleotide sequences.

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Journal:  J Gastroenterol       Date:  1997-04       Impact factor: 7.527

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5.  Self-neutralizing oligonucleotides with enhanced cellular uptake.

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6.  Nuclear antisense effects of neutral, anionic and cationic oligonucleotide analogs.

Authors:  P Sazani; S H Kang; M A Maier; C Wei; J Dillman; J Summerton; M Manoharan; R Kole
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7.  Oligoribonucleotides containing 2',5'-phosphodiester linkages exhibit binding selectivity for 3',5'-RNA over 3',5'-ssDNA.

Authors:  P A Giannaris; M J Damha
Journal:  Nucleic Acids Res       Date:  1993-10-11       Impact factor: 16.971

8.  Solid-phase synthesis and hybridization properties of DNA containing sulfide-linked dinucleosides.

Authors:  S H Kawai; D Wang; P A Giannaris; M J Damha; G Just
Journal:  Nucleic Acids Res       Date:  1993-03-25       Impact factor: 16.971

9.  Incorporation of hexose nucleoside analogues into oligonucleotides: synthesis, base-pairing properties and enzymatic stability.

Authors:  K Augustyns; F Vandendriessche; A Van Aerschot; R Busson; C Urbanke; P Herdewijn
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10.  Use of ribozymes and antisense oligodeoxynucleotides to investigate mechanisms of drug resistance.

Authors:  D Byrne; C Daly; R Nicamhlaoibh; A Howlett; K Scanlon; M Clynes
Journal:  Cytotechnology       Date:  1998-09       Impact factor: 2.058
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