Literature DB >> 8464740

Solid-phase synthesis and hybridization properties of DNA containing sulfide-linked dinucleosides.

S H Kawai1, D Wang, P A Giannaris, M J Damha, G Just.   

Abstract

Oligodeoxyribonucleotides incorporating non-hydrolyzable dialkyl sulfide linked thymidine dimers (TsT) were synthesized chemically by the solid-phase approach. The sulfide dimer TsT was stable to degradation by snake-venom phosphodiesterase, calf spleen phosphodiesterase, Nuclease P1 and Nuclease S1. Thermal denaturation analysis indicated that the incorporation of TsT dimers into DNA weakened, but did not prevent, binding to complementary DNA and RNA over a wide range of salt concentrations (10 mM to 2 M NaCl).

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Year:  1993        PMID： 8464740      PMCID： PMC309335          DOI： 10.1093/nar/21.6.1473

Source DB:  PubMed          Journal:  Nucleic Acids Res        ISSN： 0305-1048            Impact factor:   16.971


  17 in total

1.  Synthetic analogues of polynucleotides. IX. Synthesis of 3'-O-carboxymethyl-2'-deoxyribonucleosides and their use in the synthesis of an analogue of 2'-deoxyadenylyl-(3' leads to 5'-)-thymidine 3'-phosphate.

Authors:  M D Edge; A Hodgson; A S Jones; M MacCoss; R T Walker
Journal:  J Chem Soc Perkin 1       Date:  1973

2.  Activity of acid deoxyribonuclease towards diastereoisomers of thymidyl 3'-(4-nitrophenyl phosphorothioate). Stereochemistry of transnucleotidylation reaction.

Authors:  B Uznanski; W Niewiarowski; W J Stec
Journal:  J Biol Chem       Date:  1986-01-15       Impact factor: 5.157

3.  Influence of the incorporation of (S)-9-(3,4-dihydroxybutyl)adenine on the enzymatic stability and base-pairing properties of oligodeoxynucleotides.

Authors:  K Augustyns; A Van Aerschot; A Van Schepdael; C Urbanke; P Herdewijn
Journal:  Nucleic Acids Res       Date:  1991-05-25       Impact factor: 16.971

4.  Comparative inhibition of chloramphenicol acetyltransferase gene expression by antisense oligonucleotide analogues having alkyl phosphotriester, methylphosphonate and phosphorothioate linkages.

Authors:  C J Marcus-Sekura; A M Woerner; K Shinozuka; G Zon; G V Quinnan
Journal:  Nucleic Acids Res       Date:  1987-07-24       Impact factor: 16.971

5.  Oligo(alpha-deoxynucleotide)s covalently linked to intercalating agents: differential binding to ribo- and deoxyribopolynucleotides and stability towards nuclease digestion.

Authors:  N T Thuong; U Asseline; V Roig; M Takasugi; C Hélène
Journal:  Proc Natl Acad Sci U S A       Date:  1987-08       Impact factor: 11.205

6.  Inhibition of rabbit globin mRNA translation by sequence-specific oligodeoxyribonucleotides.

Authors:  K R Blake; A Murakami; P S Miller
Journal:  Biochemistry       Date:  1985-10-22       Impact factor: 3.162

7.  Phosphorothioate analogs of oligodeoxynucleotides: inhibitors of replication and cytopathic effects of human immunodeficiency virus.

Authors:  M Matsukura; K Shinozuka; G Zon; H Mitsuya; M Reitz; J S Cohen; S Broder
Journal:  Proc Natl Acad Sci U S A       Date:  1987-11       Impact factor: 11.205

8.  alpha-DNA II. Synthesis of unnatural alpha-anomeric oligodeoxyribonucleotides containing the four usual bases and study of their substrate activities for nucleases.

Authors:  F Morvan; B Rayner; J L Imbach; S Thenet; J R Bertrand; J Paoletti; C Malvy; C Paoletti
Journal:  Nucleic Acids Res       Date:  1987-04-24       Impact factor: 16.971

9.  Synthesis of hexanucleotide analogues containing diisopropylsilyl internucleotide linkages.

Authors:  J F Cormier; K K Ogilvie
Journal:  Nucleic Acids Res       Date:  1988-05-25       Impact factor: 16.971

10.  Phosphoramidate analogues of DNA: synthesis and thermal stability of heteroduplexes.

Authors:  B Froehler; P Ng; M Matteucci
Journal:  Nucleic Acids Res       Date:  1988-06-10       Impact factor: 16.971
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  2 in total

1.  Structural basis for the RNA binding selectivity of oligonucleotide analogues containing alkylsulfide internucleoside linkages and 2'-substituted 3'-deoxyribonucleosides.

Authors:  M J Damha; B Meng; D Wang; C G Yannopoulos; G Just
Journal:  Nucleic Acids Res       Date:  1995-10-11       Impact factor: 16.971

2.  Oligoribonucleotides containing 2',5'-phosphodiester linkages exhibit binding selectivity for 3',5'-RNA over 3',5'-ssDNA.

Authors:  P A Giannaris; M J Damha
Journal:  Nucleic Acids Res       Date:  1993-10-11       Impact factor: 16.971
  2 in total

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