Literature DB >> 2771641

Chromosomal localization of nucleic acid-binding proteins by affinity mapping: assignment of the IRE-binding protein gene to human chromosome 9.

M W Hentze1, H N Seuanez, S J O'Brien, J B Harford, R D Klausner.   

Abstract

Three human mRNAs are regulated post-transcriptionally by iron via iron-responsive elements (IREs) contained in each mRNA. A cytoplasmic protein (IRE-BP) binds to these cis-acting elements and mediates the translational regulation of ferritin H- and L-chain mRNA and the iron-dependent stability of transferrin receptor (TfR) mRNA. We have taken advantage of the different mobilities of the human and rodent IRE/IRE-BP complexes on non-denaturing polyacrylamide gels to determine the chromosomal localization of the gene encoding the IRE-BP. Utilizing a panel of 34 different human/rodent hybrid cell lines we have assigned the IRE-BP gene to human chromosome 9. This new technique based on nucleic acid/protein interaction may allow determination of the chromosomal localization of other RNA- or DNA-binding proteins.

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Year:  1989        PMID： 2771641      PMCID： PMC318264          DOI： 10.1093/nar/17.15.6103

Source DB:  PubMed          Journal:  Nucleic Acids Res        ISSN： 0305-1048            Impact factor:   16.971


  13 in total

1.  Segregation of ABO, AK1 and ACONs in families with abnormalities of chromosome 9.

Authors:  P J Cook; E B Robson; K E Buckton; C A Slaughter; J E Gray; C E Blank; F E James; M A Ridler; J Insley; M Hultén
Journal:  Ann Hum Genet       Date:  1978-01       Impact factor: 1.670

2.  Assignment of human ferritin genes to chromosomes 11 and 19q13.3----19qter.

Authors:  M Worwood; J D Brook; S J Cragg; B Hellkuhl; B M Jones; P Perera; S H Roberts; D J Shaw
Journal:  Hum Genet       Date:  1985       Impact factor: 4.132

3.  Dispersion of the ras family of transforming genes to four different chromosomes in man.

Authors:  S J O'Brien; W G Nash; J L Goodwin; D R Lowy; E H Chang
Journal:  Nature       Date:  1983-04-28       Impact factor: 49.962

4.  Cloning, characterization, expression, and chromosomal localization of a human ferritin heavy-chain gene.

Authors:  M W Hentze; S Keim; P Papadopoulos; S O'Brien; W Modi; J Drysdale; W J Leonard; J B Harford; R D Klausner
Journal:  Proc Natl Acad Sci U S A       Date:  1986-10       Impact factor: 11.205

5.  A model for the structure and functions of iron-responsive elements.

Authors:  M W Hentze; S W Caughman; J L Casey; D M Koeller; T A Rouault; J B Harford; R D Klausner
Journal:  Gene       Date:  1988-12-10       Impact factor: 3.688

6.  Genetic mapping in mammals: chromosome map of domestic cat.

Authors:  S J O'Brien; W G Nash
Journal:  Science       Date:  1982-04-16       Impact factor: 47.728

7.  Identification of the iron-responsive element for the translational regulation of human ferritin mRNA.

Authors:  M W Hentze; S W Caughman; T A Rouault; J G Barriocanal; A Dancis; J B Harford; R D Klausner
Journal:  Science       Date:  1987-12-11       Impact factor: 47.728

8.  Iron regulates ferritin mRNA translation through a segment of its 5' untranslated region.

Authors:  N Aziz; H N Munro
Journal:  Proc Natl Acad Sci U S A       Date:  1987-12       Impact factor: 11.205

9.  Genetic linkage between hereditary hemochromatosis and HLA.

Authors:  K Kravitz; M Skolnick; C Cannings; D Carmelli; B Baty; B Amos; A Johnson; N Mendell; C Edwards; G Cartwright
Journal:  Am J Hum Genet       Date:  1979-09       Impact factor: 11.025

10.  Cytoplasmic protein binds in vitro to a highly conserved sequence in the 5' untranslated region of ferritin heavy- and light-subunit mRNAs.

Authors:  E A Leibold; H N Munro
Journal:  Proc Natl Acad Sci U S A       Date:  1988-04       Impact factor: 11.205
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  12 in total

Review 1.  MRNA stability and the control of gene expression: implications for human disease.

Authors:  Elysia M Hollams; Keith M Giles; Andrew M Thomson; Peter J Leedman
Journal:  Neurochem Res       Date:  2002-10       Impact factor: 3.996

2.  Position is the critical determinant for function of iron-responsive elements as translational regulators.

Authors:  B Goossen; M W Hentze
Journal:  Mol Cell Biol       Date:  1992-05       Impact factor: 4.272

3.  A regulated RNA binding protein also possesses aconitase activity.

Authors:  S Kaptain; W E Downey; C Tang; C Philpott; D Haile; D G Orloff; J B Harford; T A Rouault; R D Klausner
Journal:  Proc Natl Acad Sci U S A       Date:  1991-11-15       Impact factor: 11.205

4.  Iron Regulatory Protein 2 Exerts its Oncogenic Activities by Suppressing TAp63 Expression.

Authors:  Yanhong Zhang; Xiuli Feng; Jin Zhang; Xinbin Chen
Journal:  Mol Cancer Res       Date:  2020-04-10       Impact factor: 5.852

5.  Exclusion of ferritins and iron-responsive element (IRE)-binding proteins as candidates for the hemochromatosis gene.

Authors:  H Zheng; D Bhavsar; A Volz; A Ziegler; J Drysdale
Journal:  Hum Genet       Date:  1994-08       Impact factor: 4.132

6.  Cloning of the cDNA encoding an RNA regulatory protein--the human iron-responsive element-binding protein.

Authors:  T A Rouault; C K Tang; S Kaptain; W H Burgess; D J Haile; F Samaniego; O W McBride; J B Harford; R D Klausner
Journal:  Proc Natl Acad Sci U S A       Date:  1990-10       Impact factor: 11.205

7.  Expression of active iron regulatory factor from a full-length human cDNA by in vitro transcription/translation.

Authors:  H Hirling; A Emery-Goodman; N Thompson; B Neupert; C Seiser; L C Kühn
Journal:  Nucleic Acids Res       Date:  1992-01-11       Impact factor: 16.971

8.  Homology between IRE-BP, a regulatory RNA-binding protein, aconitase, and isopropylmalate isomerase.

Authors:  M W Hentze; P Argos
Journal:  Nucleic Acids Res       Date:  1991-04-25       Impact factor: 16.971

9.  Identification of a novel iron-responsive element in murine and human erythroid delta-aminolevulinic acid synthase mRNA.

Authors:  T Dandekar; R Stripecke; N K Gray; B Goossen; A Constable; H E Johansson; M W Hentze
Journal:  EMBO J       Date:  1991-07       Impact factor: 11.598

10.  Translational repression by a complex between the iron-responsive element of ferritin mRNA and its specific cytoplasmic binding protein is position-dependent in vivo.

Authors:  B Goossen; S W Caughman; J B Harford; R D Klausner; M W Hentze
Journal:  EMBO J       Date:  1990-12       Impact factor: 11.598
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