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Literature DB >> 27709809

Regulating Stem Cell Secretome Using Injectable Hydrogels with In Situ Network Formation.

Lei Cai¹, Ruby E Dewi², Andrew B Goldstone³, Jeffrey E Cohen³, Amanda N Steele³, Y Joseph Woo³, Sarah C Heilshorn⁴.

Abstract

A family of shear-thinning hydrogels for injectable encapsulation and long-term delivery (SHIELD) has been designed and synthesized with controlled in situ stiffening properties to regulate the stem cell secretome. The authors demonstrate that SHIELD with an intermediate stiffness (200-400 Pa) could significantly promote the angiogenic potential of human adipose-derived stem cells.

Entities: Chemical Disease Gene Species

Keywords: angiogenic function; injectable hydrogels; molecular recognition; reinforcing network; stem cell secretome

Mesh：

Substances：

Year: 2016 PMID： 27709809 PMCID： PMC5521188 DOI： 10.1002/adhm.201600497

Source DB: PubMed Journal: Adv Healthc Mater ISSN： 2192-2640 Impact factor: 9.933

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