Literature DB >> 22385653

Harnessing the mesenchymal stem cell secretome for the treatment of cardiovascular disease.

Sudhir H Ranganath1, Oren Levy, Maneesha S Inamdar, Jeffrey M Karp.   

Abstract

The broad repertoire of secreted trophic and immunomodulatory cytokines produced by mesenchymal stem cells (MSCs), generally referred to as the MSC secretome, has considerable potential for the treatment of cardiovascular disease. However, harnessing this MSC secretome for meaningful therapeutic outcomes is challenging due to the limited control of cytokine production following their transplantation. This review outlines the current understanding of the MSC secretome as a therapeutic for treatment of ischemic heart disease. We discuss ongoing investigative directions aimed at improving cellular activity and characterizing the secretome and its regulation in greater detail. Finally, we provide insights on and perspectives for future development of the MSC secretome as a therapeutic tool. Copyright Â
© 2012 Elsevier Inc. All rights reserved.

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Year:  2012        PMID： 22385653      PMCID： PMC3294273          DOI： 10.1016/j.stem.2012.02.005

Source DB:  PubMed          Journal:  Cell Stem Cell        ISSN： 1875-9777            Impact factor:   24.633


  120 in total

1.  Genetic modification of mesenchymal stem cells overexpressing CCR1 increases cell viability, migration, engraftment, and capillary density in the injured myocardium.

Authors:  Jing Huang; Zhiping Zhang; Jian Guo; Aiguo Ni; Arjun Deb; Lunan Zhang; Maria Mirotsou; Richard E Pratt; Victor J Dzau
Journal:  Circ Res       Date:  2010-04-08       Impact factor: 17.367

2.  Assessment of a nuclear affinity labeling method for tracking implanted mesenchymal stem cells.

Authors:  Merced Leiker; Gen Suzuki; Vijay S Iyer; John M Canty; Techung Lee
Journal:  Cell Transplant       Date:  2008       Impact factor: 4.064

3.  Bone marrow mesenchymal stem cells stimulate cardiac stem cell proliferation and differentiation.

Authors:  Konstantinos E Hatzistergos; Henry Quevedo; Behzad N Oskouei; Qinghua Hu; Gary S Feigenbaum; Irene S Margitich; Ramesh Mazhari; Andrew J Boyle; Juan P Zambrano; Jose E Rodriguez; Raul Dulce; Pradip M Pattany; David Valdes; Concepcion Revilla; Alan W Heldman; Ian McNiece; Joshua M Hare
Journal:  Circ Res       Date:  2010-07-29       Impact factor: 17.367

4.  Intracoronary administration of recombinant human vascular endothelial growth factor to patients with coronary artery disease.

Authors:  T D Henry; K Rocha-Singh; J M Isner; D J Kereiakes; F J Giordano; M Simons; D W Losordo; R C Hendel; R O Bonow; S M Eppler; T F Zioncheck; E B Holmgren; E R McCluskey
Journal:  Am Heart J       Date:  2001-11       Impact factor: 4.749

5.  IL-6 and TGF-α costimulate mesenchymal stem cell vascular endothelial growth factor production by ERK-, JNK-, and PI3K-mediated mechanisms.

Authors:  Jeremy L Herrmann; Brent R Weil; Aaron M Abarbanell; Yue Wang; Jeffrey A Poynter; Mariuxi C Manukyan; Daniel R Meldrum
Journal:  Shock       Date:  2011-05       Impact factor: 3.454

6.  Human mesenchymal stem cells modulate allogeneic immune cell responses.

Authors:  Sudeepta Aggarwal; Mark F Pittenger
Journal:  Blood       Date:  2004-10-19       Impact factor: 22.113

7.  Monolayered mesenchymal stem cells repair scarred myocardium after myocardial infarction.

Authors:  Yoshinori Miyahara; Noritoshi Nagaya; Masaharu Kataoka; Bobby Yanagawa; Koichi Tanaka; Hiroyuki Hao; Kozo Ishino; Hideyuki Ishida; Tatsuya Shimizu; Kenji Kangawa; Shunji Sano; Teruo Okano; Soichiro Kitamura; Hidezo Mori
Journal:  Nat Med       Date:  2006-04-02       Impact factor: 53.440

8.  Mesenchymal stem cells modified with stromal cell-derived factor 1 alpha improve cardiac remodeling via paracrine activation of hepatocyte growth factor in a rat model of myocardial infarction.

Authors:  Junming Tang; Jianing Wang; Linyun Guo; Xia Kong; Jianye Yang; Fei Zheng; Lei Zhang; Yongzhang Huang
Journal:  Mol Cells       Date:  2009-12-07       Impact factor: 5.034

9.  Genetic engineering of human stem cells for enhanced angiogenesis using biodegradable polymeric nanoparticles.

Authors:  Fan Yang; Seung-Woo Cho; Sun Mi Son; Said R Bogatyrev; Deepika Singh; Jordan J Green; Ying Mei; Sohyun Park; Suk Ho Bhang; Byung-Soo Kim; Robert Langer; Daniel G Anderson
Journal:  Proc Natl Acad Sci U S A       Date:  2009-10-05       Impact factor: 11.205

10.  Mesenchymal stem cell-derived molecules reverse fulminant hepatic failure.

Authors:  Biju Parekkadan; Daan van Poll; Kazuhiro Suganuma; Edward A Carter; François Berthiaume; Arno W Tilles; Martin L Yarmush
Journal:  PLoS One       Date:  2007-09-26       Impact factor: 3.240
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  320 in total

Review 1.  Optimizing cardiac repair and regeneration through activation of the endogenous cardiac stem cell compartment.

Authors:  Georgina M Ellison; Bernardo Nadal-Ginard; Daniele Torella
Journal:  J Cardiovasc Transl Res       Date:  2012-06-12       Impact factor: 4.132

Review 2.  The Role of Chemokines in Mesenchymal Stem Cell Homing to Wounds.

Authors:  Anne M Hocking
Journal:  Adv Wound Care (New Rochelle)       Date:  2015-11-01       Impact factor: 4.730

3.  Cell sheet biofabrication by co-administration of mesenchymal stem cells secretome and vitamin C on thermoresponsive polymer.

Authors:  Behnaz Banimohammad Shotorbani; Helder André; Abolfazl Barzegar; Nosratollah Zarghami; Roya Salehi; Effat Alizadeh
Journal:  J Mater Sci Mater Med       Date:  2018-11-03       Impact factor: 3.896

Review 4.  Manufacturing Cell Therapies Using Engineered Biomaterials.

Authors:  Amr A Abdeen; Krishanu Saha
Journal:  Trends Biotechnol       Date:  2017-07-12       Impact factor: 19.536

5.  Lipopolysaccharides Improve Mesenchymal Stem Cell-Mediated Cardioprotection by MyD88 and stat3 Signaling in a Mouse Model of Cardiac Ischemia/Reperfusion Injury.

Authors:  Xiaona Chu; Bing Xu; Hongyu Gao; Bai-Yan Li; Yunlong Liu; Jill L Reiter; Yue Wang
Journal:  Stem Cells Dev       Date:  2019-04-11       Impact factor: 3.272

Review 6.  Mixing old and young: enhancing rejuvenation and accelerating aging.

Authors:  Ashley Lau; Brian K Kennedy; James L Kirkland; Stefan G Tullius
Journal:  J Clin Invest       Date:  2019-01-02       Impact factor: 14.808

7.  Function of Cryopreserved Mesenchymal Stromal Cells With and Without Interferon-γ Prelicensing is Context Dependent.

Authors:  Anthony J Burand; Oliver W Gramlich; Alex J Brown; James A Ankrum
Journal:  Stem Cells       Date:  2016-11-10       Impact factor: 6.277

8.  Tumor-infiltrating mesenchymal stem cells: Drivers of the immunosuppressive tumor microenvironment in prostate cancer?

Authors:  Timothy E Krueger; Daniel L J Thorek; Alan K Meeker; John T Isaacs; W Nathaniel Brennen
Journal:  Prostate       Date:  2018-11-28       Impact factor: 4.104

9.  Surface Tethering of Inflammation-Modulatory Nanostimulators to Stem Cells for Ischemic Muscle Repair.

Authors:  Jiayu Leong; Yu-Tong Hong; Yu-Fu Wu; Eunkyung Ko; Svyatoslav Dvoretskiy; Jye Yng Teo; Byoung Soo Kim; Kyeongsoo Kim; Hojeong Jeon; Marni Boppart; Yi Yan Yang; Hyunjoon Kong
Journal:  ACS Nano       Date:  2020-04-13       Impact factor: 15.881

Review 10.  Mesenchymal stem cells secretome: a new paradigm for central nervous system regeneration?

Authors:  Fábio G Teixeira; Miguel M Carvalho; Nuno Sousa; António J Salgado
Journal:  Cell Mol Life Sci       Date:  2013-03-01       Impact factor: 9.261
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