Julia R Van Liew1, Rebecca L Brock2, Alan J Christensen1,3, Lucy Hynds Karnell4, Nitin A Pagedar4, Gerry F Funk5. 1. Department of Psychology, The University of Iowa, Iowa City, Iowa. 2. Department of Psychology, The University of Nebraska - Lincoln, Lincoln, Nebraska. 3. Department of Internal Medicine, The University of Iowa College of Medicine, Iowa City, Iowa. 4. Department of Otolaryngology - Head and Neck Surgery, The University of Iowa College of Medicine, Iowa City, Iowa. 5. Department of Otolaryngology, Grande Ronde Hospitals and Clinics, La Grande, Oregon.
Abstract
BACKGROUND: Weight loss and depressive symptoms are critical head and neck cancer outcomes, yet their relation over the illness course is unclear. METHODS: Associations between self-reported depressive symptoms and objective weight loss across the year after head and neck cancer diagnosis were examined using growth curve modeling techniques (n = 564). RESULTS: A reciprocal covariation pattern emerged-changes in depressive symptoms over time were associated with same-month changes in weight loss (t [1148] = 2.05; p = .041), and changes in weight loss were associated with same-month changes in depressive symptoms (t [556] = 2.43; p = .015). To the extent that depressive symptoms increased, patients lost incrementally more weight than was lost due to the passage of time and vice versa. Results also suggested that pain and eating-related quality of life might explain the reciprocal association between depressive symptoms and weight loss. CONCLUSION: In head and neck cancer, a transactional interplay between depressive symptoms and weight loss unfolds over time.
BACKGROUND:Weight loss and depressive symptoms are critical head and neck cancer outcomes, yet their relation over the illness course is unclear. METHODS: Associations between self-reported depressive symptoms and objective weight loss across the year after head and neck cancer diagnosis were examined using growth curve modeling techniques (n = 564). RESULTS: A reciprocal covariation pattern emerged-changes in depressive symptoms over time were associated with same-month changes in weight loss (t [1148] = 2.05; p = .041), and changes in weight loss were associated with same-month changes in depressive symptoms (t [556] = 2.43; p = .015). To the extent that depressive symptoms increased, patients lost incrementally more weight than was lost due to the passage of time and vice versa. Results also suggested that pain and eating-related quality of life might explain the reciprocal association between depressive symptoms and weight loss. CONCLUSION: In head and neck cancer, a transactional interplay between depressive symptoms and weight loss unfolds over time.
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