Literature DB >> 27695712

RNA Editing Dynamically Rewrites the Cancer Code.

Violeta Rayon-Estrada1, F Nina Papavasiliou2, Dewi Harjanto2.   

Abstract

Global analyses of cancer transcriptomes demonstrate that ADAR (adenosine deaminase, RNA-specific)-mediated RNA editing dynamically contributes to genetic alterations in cancer, and directly correlates with progression and prognosis. RNA editing is abundant and frequently elevated in cancer, and affects functionally and clinically relevant sites in both coding and non-coding regions of the transcriptome. Therefore, ADAR and differentially edited transcripts may be promising biomarkers or targets for therapy.

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Year:  2015        PMID： 27695712      PMCID： PMC5042206          DOI： 10.1016/j.trecan.2015.10.008

Source DB:  PubMed          Journal:  Trends Cancer        ISSN： 2405-8025


  10 in total

1.  miR-EdiTar: a database of predicted A-to-I edited miRNA target sites.

Authors:  Alessandro Laganà; Alessio Paone; Dario Veneziano; Luciano Cascione; Pierluigi Gasparini; Stefania Carasi; Francesco Russo; Giovanni Nigita; Valentina Macca; Rosalba Giugno; Alfredo Pulvirenti; Dennis Shasha; Alfredo Ferro; Carlo M Croce
Journal:  Bioinformatics       Date:  2012-10-07       Impact factor: 6.937

2.  The Genomic Landscape and Clinical Relevance of A-to-I RNA Editing in Human Cancers.

Authors:  Leng Han; Lixia Diao; Shuangxing Yu; Xiaoyan Xu; Jie Li; Rui Zhang; Yang Yang; Henrica M J Werner; A Karina Eterovic; Yuan Yuan; Jun Li; Nikitha Nair; Rosalba Minelli; Yiu Huen Tsang; Lydia W T Cheung; Kang Jin Jeong; Jason Roszik; Zhenlin Ju; Scott E Woodman; Yiling Lu; Kenneth L Scott; Jin Billy Li; Gordon B Mills; Han Liang
Journal:  Cancer Cell       Date:  2015-10-01       Impact factor: 31.743

3.  Recoding RNA editing of AZIN1 predisposes to hepatocellular carcinoma.

Authors:  Leilei Chen; Yan Li; Chi Ho Lin; Tim Hon Man Chan; Raymond Kwok Kei Chow; Yangyang Song; Ming Liu; Yun-Fei Yuan; Li Fu; Kar Lok Kong; Lihua Qi; Yan Li; Na Zhang; Amy Hin Yan Tong; Dora Lai-Wan Kwong; Kwan Man; Chung Mau Lo; Si Lok; Daniel G Tenen; Xin-Yuan Guan
Journal:  Nat Med       Date:  2013-01-06       Impact factor: 53.440

4.  Messenger RNA editing of the human serotonin 5-HT2C receptor.

Authors:  L W Fitzgerald; G Iyer; D S Conklin; C M Krause; A Marshall; J P Patterson; D P Tran; G J Jonak; P R Hartig
Journal:  Neuropsychopharmacology       Date:  1999-08       Impact factor: 7.853

5.  Regulation of alternative splicing by RNA editing.

Authors:  S M Rueter; T R Dawson; R B Emeson
Journal:  Nature       Date:  1999-05-06       Impact factor: 49.962

6.  Elevated RNA Editing Activity Is a Major Contributor to Transcriptomic Diversity in Tumors.

Authors:  Nurit Paz-Yaacov; Lily Bazak; Ilana Buchumenski; Hagit T Porath; Miri Danan-Gotthold; Binyamin A Knisbacher; Eli Eisenberg; Erez Y Levanon
Journal:  Cell Rep       Date:  2015-10-01       Impact factor: 9.423

7.  Reduced adenosine-to-inosine miR-455-5p editing promotes melanoma growth and metastasis.

Authors:  Einav Shoshan; Aaron K Mobley; Russell R Braeuer; Takafumi Kamiya; Li Huang; Mayra E Vasquez; Ahmad Salameh; Ho Jeong Lee; Sun Jin Kim; Cristina Ivan; Guermarie Velazquez-Torres; Ka Ming Nip; Kelsey Zhu; Denise Brooks; Steven J M Jones; Inanc Birol; Maribel Mosqueda; Yu-ye Wen; Agda Karina Eterovic; Anil K Sood; Patrick Hwu; Jeffrey E Gershenwald; A Gordon Robertson; George A Calin; Gal Markel; Isaiah J Fidler; Menashe Bar-Eli
Journal:  Nat Cell Biol       Date:  2015-02-16       Impact factor: 28.824

8.  A-to-I RNA editing occurs at over a hundred million genomic sites, located in a majority of human genes.

Authors:  Lily Bazak; Ami Haviv; Michal Barak; Jasmine Jacob-Hirsch; Patricia Deng; Rui Zhang; Farren J Isaacs; Gideon Rechavi; Jin Billy Li; Eli Eisenberg; Erez Y Levanon
Journal:  Genome Res       Date:  2013-12-17       Impact factor: 9.043

9.  RNA editing in RHOQ promotes invasion potential in colorectal cancer.

Authors:  Sae-Won Han; Hwang-Phill Kim; Jong-Yeon Shin; Eun-Goo Jeong; Won-Chul Lee; Keon Young Kim; Sang Youn Park; Dae-Won Lee; Jae-Kyung Won; Seung-Yong Jeong; Kyu Joo Park; Jae-Gahb Park; Gyeong Hoon Kang; Jeong-Sun Seo; Jong-Il Kim; Tae-You Kim
Journal:  J Exp Med       Date:  2014-03-24       Impact factor: 14.307

10.  Principles Governing A-to-I RNA Editing in the Breast Cancer Transcriptome.

Authors:  Debora Fumagalli; David Gacquer; Françoise Rothé; Anne Lefort; Frederick Libert; David Brown; Naima Kheddoumi; Adam Shlien; Tomasz Konopka; Roberto Salgado; Denis Larsimont; Kornelia Polyak; Karen Willard-Gallo; Christine Desmedt; Martine Piccart; Marc Abramowicz; Peter J Campbell; Christos Sotiriou; Vincent Detours
Journal:  Cell Rep       Date:  2015-10-01       Impact factor: 9.423
  10 in total
  7 in total

1.  Restricting retrotransposons: ADAR1 is another guardian of the human genome.

Authors:  Elisa Orecchini; Loredana Frassinelli; Alessandro Michienzi
Journal:  RNA Biol       Date:  2017-07-21       Impact factor: 4.652

2.  RNA-editing enzymes ADAR1 and ADAR2 coordinately regulate the editing and expression of Ctn RNA.

Authors:  Aparna Anantharaman; Omid Gholamalamdari; Abid Khan; Je-Hyun Yoon; Michael F Jantsch; Jochen C Hartner; Myriam Gorospe; Supriya G Prasanth; Kannanganattu V Prasanth
Journal:  FEBS Lett       Date:  2017-08-30       Impact factor: 4.124

Review 3.  Post-transcriptional regulation of LINE-1 retrotransposition by AID/APOBEC and ADAR deaminases.

Authors:  Elisa Orecchini; Loredana Frassinelli; Silvia Galardi; Silvia Anna Ciafrè; Alessandro Michienzi
Journal:  Chromosome Res       Date:  2018-02-02       Impact factor: 5.239

4.  Metabolomic and Lipidomic Profiling Identifies The Role of the RNA Editing Pathway in Endometrial Carcinogenesis.

Authors:  Tatiana Altadill; Tyrone M Dowdy; Kirandeep Gill; Armando Reques; Smrithi S Menon; Cristian P Moiola; Carlos Lopez-Gil; Eva Coll; Xavier Matias-Guiu; Silvia Cabrera; Angel Garcia; Jaume Reventos; Stephen W Byers; Antonio Gil-Moreno; Amrita K Cheema; Eva Colas
Journal:  Sci Rep       Date:  2017-08-18       Impact factor: 4.379

5.  RNA Editing Alters miRNA Function in Chronic Lymphocytic Leukemia.

Authors:  Franz J Gassner; Nadja Zaborsky; Daniel Feldbacher; Richard Greil; Roland Geisberger
Journal:  Cancers (Basel)       Date:  2020-05-05       Impact factor: 6.639

6.  Editome Disease Knowledgebase (EDK): a curated knowledgebase of editome-disease associations in human.

Authors:  Guangyi Niu; Dong Zou; Mengwei Li; Yuansheng Zhang; Jian Sang; Lin Xia; Man Li; Lin Liu; Jiabao Cao; Yang Zhang; Pei Wang; Songnian Hu; Lili Hao; Zhang Zhang
Journal:  Nucleic Acids Res       Date:  2019-01-08       Impact factor: 16.971

7.  RNA editing alterations define manifestation of prion diseases.

Authors:  Eirini Kanata; Franc Llorens; Dimitra Dafou; Athanasios Dimitriadis; Katrin Thüne; Konstantinos Xanthopoulos; Nikolaos Bekas; Juan Carlos Espinosa; Matthias Schmitz; Alba Marín-Moreno; Vincenzo Capece; Orr Shormoni; Olivier Andréoletti; Stefan Bonn; Juan María Torres; Isidre Ferrer; Inga Zerr; Theodoros Sklaviadis
Journal:  Proc Natl Acad Sci U S A       Date:  2019-09-06       Impact factor: 11.205
  7 in total

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