Federico Sista1, Valentina Abruzzese2, Marco Clementi2, Sergio Carandina3, Manuela Cecilia2, Gianfranco Amicucci2. 1. Dipartimento di Scienze Cliniche Applicate e Biotecnologie (DISCAB), Ospedale civile San Salvatore, University of L'Aquila, L'Aquila, Italy. Electronic address: silversista@gmail.com. 2. Dipartimento di Scienze Cliniche Applicate e Biotecnologie (DISCAB), Ospedale civile San Salvatore, University of L'Aquila, L'Aquila, Italy. 3. Service de Chirurgie Digestive, Hôpital Avicenne , Université Paris XIII, Bobigny, France.
Abstract
BACKGROUND: Rapid gastric emptying has been proposed to justify the increase in glucagon-like polypeptide-1 (GLP-1) after laparoscopic sleeve gastrectomy (LSG). OBJECTIVES: To assess gastric emptying changes after LSG and their relationship with GLP-1 secretion. SETTING: San Salvatore Hospital general surgery unit, University of L'Aquila, Italy. METHODS: 52 patients underwent gastric emptying scintigraphy for liquid and solid foods, before and 3 months after LSG. Twenty-six patients were in the liquid group (L group) and the remaining in the solid group (S group). We evaluated the half time of gastric emptying (T1/2) and percentage of gastric retention (%GR) at 15, 30, and 60 minutes for liquids and at 30, 60, 90, and 120 minutes for solids. GLP-1 plasma concentrations were measured in each group before and after LSG and related to %GR. Statistical analysis was performed by Χ2 test and Pearson correlation(r). RESULTS: After surgery, T1/2 was significantly accelerated: 15.2±13 min and 33.5±18 min in the L group and S group, respectively (P<.05). In both groups, GLP-1 plasma concentrations were increased at each blood sampling time: 2.91±2.9 pg/mL, 3.06±3.1 pg/mL and 3.21±2.6 pg/mL at 15, 30, and 60 minutes, respectively, (P<.05) for L group and 2.72±1.5 pg/mL, 2.89±2.1 pg/mL, 2.93±1.8 pg/mL, and 2.95±1.9 pg/mL at 30, 60, 90, and 120 minutes, respectively, (P< .05) for the S group. After LSG, GLP-1 and %GR presented a negative linear correlation (r) at each blood sampling time in both groups. CONCLUSION: The rapid gastric emptying 3 months after LSG upregulates the production of GLP-1 in the distal bowel. Further studies are needed to confirm these findings.
BACKGROUND: Rapid gastric emptying has been proposed to justify the increase in glucagon-like polypeptide-1 (GLP-1) after laparoscopic sleeve gastrectomy (LSG). OBJECTIVES: To assess gastric emptying changes after LSG and their relationship with GLP-1 secretion. SETTING: San Salvatore Hospital general surgery unit, University of L'Aquila, Italy. METHODS: 52 patients underwent gastric emptying scintigraphy for liquid and solid foods, before and 3 months after LSG. Twenty-six patients were in the liquid group (L group) and the remaining in the solid group (S group). We evaluated the half time of gastric emptying (T1/2) and percentage of gastric retention (%GR) at 15, 30, and 60 minutes for liquids and at 30, 60, 90, and 120 minutes for solids. GLP-1 plasma concentrations were measured in each group before and after LSG and related to %GR. Statistical analysis was performed by Χ2 test and Pearson correlation(r). RESULTS: After surgery, T1/2 was significantly accelerated: 15.2±13 min and 33.5±18 min in the L group and S group, respectively (P<.05). In both groups, GLP-1 plasma concentrations were increased at each blood sampling time: 2.91±2.9 pg/mL, 3.06±3.1 pg/mL and 3.21±2.6 pg/mL at 15, 30, and 60 minutes, respectively, (P<.05) for L group and 2.72±1.5 pg/mL, 2.89±2.1 pg/mL, 2.93±1.8 pg/mL, and 2.95±1.9 pg/mL at 30, 60, 90, and 120 minutes, respectively, (P< .05) for the S group. After LSG, GLP-1 and %GR presented a negative linear correlation (r) at each blood sampling time in both groups. CONCLUSION: The rapid gastric emptying 3 months after LSG upregulates the production of GLP-1 in the distal bowel. Further studies are needed to confirm these findings.
Authors: María Belén Acevedo; J Christopher Eagon; Bruce D Bartholow; Samuel Klein; Kathleen K Bucholz; Marta Yanina Pepino Journal: Surg Obes Relat Dis Date: 2017-11-10 Impact factor: 4.734
Authors: Naji Alamuddin; Marion L Vetter; Rexford S Ahima; Louise Hesson; Scott Ritter; Alyssa Minnick; Lucy F Faulconbridge; Kelly C Allison; David B Sarwer; Jesse Chittams; Noel N Williams; Matthew R Hayes; James W Loughead; Ruben Gur; Thomas A Wadden Journal: Obes Surg Date: 2017-06 Impact factor: 4.129
Authors: M Vives; A Molina; M Danús; E Rebenaque; S Blanco; M París; A Sánchez; F Sabench; D Del Castillo Journal: Obes Surg Date: 2017-11 Impact factor: 4.129