Literature DB >> 15238780

A single-nucleotide polymorphism in the human beta-defensin 1 gene is associated with HIV-1 infection in Italian children.

Laura Braida1, Michele Boniotto, Alessandra Pontillo, Pier Angelo Tovo, Antonio Amoroso, Sergio Crovella.   

Abstract

In this study we show a significant correlation between a single-nucleotide polymorphism in the 5'-untranslated region of the DEFB1 gene, which probably regulates the gene expression of human beta defensin 1 (hBD-1) and the risk of HIV-1 infection in an Italian paediatric population (97 HIV-1 perinatally infected children), pointing to the importance of innate immunity in HIV-1 infection.

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Year:  2004        PMID： 15238780     DOI： 10.1097/01.aids.0000131363.82951.fb

Source DB:  PubMed          Journal:  AIDS        ISSN： 0269-9370            Impact factor:   4.177


  48 in total

1.  A case of bilateral endophthalmitis and carriage of beta-defensin 1 44CC genotype.

Authors:  James Carter; Amanda J Churchill; Chris Gorman; Richard Haynes
Journal:  Br J Ophthalmol       Date:  2007-09       Impact factor: 4.638

2.  Role of urinary cathelicidin LL-37 and human β-defensin 1 in uncomplicated Escherichia coli urinary tract infections.

Authors:  Karen L Nielsen; Pia Dynesen; Preben Larsen; Lotte Jakobsen; Paal S Andersen; Niels Frimodt-Møller
Journal:  Infect Immun       Date:  2014-01-22       Impact factor: 3.441

Review 3.  Multifunctional antimicrobial peptides: therapeutic targets in several human diseases.

Authors:  Mohamed Zaiou
Journal:  J Mol Med (Berl)       Date:  2007-01-10       Impact factor: 4.599

4.  Human beta-defensins suppress human immunodeficiency virus infection: potential role in mucosal protection.

Authors:  Lingling Sun; Catherine M Finnegan; Tina Kish-Catalone; Robert Blumenthal; Paolo Garzino-Demo; Gian M La Terra Maggiore; Sid Berrone; Carol Kleinman; Zhibin Wu; Sayed Abdelwahab; Wuyuan Lu; Alfredo Garzino-Demo
Journal:  J Virol       Date:  2005-11       Impact factor: 5.103

5.  Increased levels of human beta-defensins mRNA in sexually HIV-1 exposed but uninfected individuals.

Authors:  Wildeman Zapata; Benigno Rodriguez; Jan Weber; Hernando Estrada; Miguel E Quiñones-Mateu; Peter A Zimermman; Michael M Lederman; Maria T Rugeles
Journal:  Curr HIV Res       Date:  2008-11       Impact factor: 1.581

Review 6.  The roles of antimicrobial peptides in innate host defense.

Authors:  Gill Diamond; Nicholas Beckloff; Aaron Weinberg; Kevin O Kisich
Journal:  Curr Pharm Des       Date:  2009       Impact factor: 3.116

7.  Novel hairpin-shaped primer assay to study the association of the -44 single-nucleotide polymorphism of the DEFB1 gene with early-onset periodontal disease.

Authors:  Michele Boniotto; Manzour Hernando Hazbón; William James Jordan; Greig Patrick Lennon; Joyce Eskdale; David Alland; Grant Gallagher
Journal:  Clin Diagn Lab Immunol       Date:  2004-07

8.  Cyclic and acyclic defensins inhibit human immunodeficiency virus type-1 replication by different mechanisms.

Authors:  Aprille Seidel; Ying Ye; Lesley R de Armas; Maira Soto; William Yarosh; Renee A Marcsisin; Dat Tran; Michael E Selsted; David Camerini
Journal:  PLoS One       Date:  2010-03-17       Impact factor: 3.240

Review 9.  Susceptibility to infectious diseases based on antimicrobial peptide production.

Authors:  Bruno Rivas-Santiago; Carmen J Serrano; J Antonio Enciso-Moreno
Journal:  Infect Immun       Date:  2009-08-24       Impact factor: 3.441

10.  Association of a genetic polymorphism (-44 C/G SNP) in the human DEFB1 gene with expression and inducibility of multiple beta-defensins in gingival keratinocytes.

Authors:  Andrea A Kalus; L Page Fredericks; Beth M Hacker; Henrik Dommisch; Richard B Presland; Janet R Kimball; Beverly A Dale
Journal:  BMC Oral Health       Date:  2009-08-27       Impact factor: 2.757
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