Marine Claudin1, Laetitia Imbert2,3,4, Wassila Djaballah1,5, Nicolas Veran1,6, Sylvain Poussier6,5, Véronique Roch1,6, Mathieu Perrin1, Antoine Verger1,6,5, Henri Boutley6, Gilles Karcher1,6,5, Pierre-Yves Marie1,6,7. 1. Department of Nuclear Medicine, CHU-Nancy, Nancy, France. 2. Department of Nuclear Medicine, CHU-Nancy, Nancy, France. l.imbert@chu-nancy.fr. 3. Nancyclotep Molecular Imaging Platform, Nancy, France. l.imbert@chu-nancy.fr. 4. UMR 7039 CRAN and Université de Lorraine, Nancy, France. l.imbert@chu-nancy.fr. 5. INSERM U947 and Université de Lorraine, Nancy, France. 6. Nancyclotep Molecular Imaging Platform, Nancy, France. 7. INSERM U1116 and Université de Lorraine, Nancy, France.
Abstract
PURPOSE: Gamma-cameras, with Cadmium-Zinc-Telluride (CZT) detectors, allow to perform myocardial perfusion imaging (MPI) with limited injected activities and recorded times. This study aimed at determining whether the routine assessment of left ventricular (LV) function with such limited counts protocols compares well with reference values from cardiac MRI. METHODS: The study included patients who have undergone cardiac MRI and an MPI routinely planned on a CZT camera with a low-dose protocol (120 MBq of Sestamibi for stress and 360 MBq at rest for 75 kg body weight), while targeting the recording of only 500 myocardial kcounts in order to limit the recording times (<10 minutes for stress, <4 minutes for rest). SPECT images were reconstructed with a method maintaining rather high spatial (8 mm) and temporal (16 frames/cycle) resolutions. RESULTS: Seventy-six patients were included, and mean effective dose was 3.5 ± 1.7 mSv for the total MPI protocol. Correlations between CZT-SPECT and MRI were good to excellent for ejection fraction (r 2 = 0.77), end-diastolic (r 2 = 0.88) and end-systolic (r 2 = 0.93) volumes, and the analysis of segmental contractility correlated well between the two techniques (kappa score = 0.72 ± 0.02). CONCLUSION: LV function, assessed on a CZT camera with low injected activities and limited recording times, correlates well with the reference assessment from cardiac MRI.
PURPOSE: Gamma-cameras, with Cadmium-Zinc-Telluride (CZT) detectors, allow to perform myocardial perfusion imaging (MPI) with limited injected activities and recorded times. This study aimed at determining whether the routine assessment of left ventricular (LV) function with such limited counts protocols compares well with reference values from cardiac MRI. METHODS: The study included patients who have undergone cardiac MRI and an MPI routinely planned on a CZT camera with a low-dose protocol (120 MBq of Sestamibi for stress and 360 MBq at rest for 75 kg body weight), while targeting the recording of only 500 myocardial kcounts in order to limit the recording times (<10 minutes for stress, <4 minutes for rest). SPECT images were reconstructed with a method maintaining rather high spatial (8 mm) and temporal (16 frames/cycle) resolutions. RESULTS: Seventy-six patients were included, and mean effective dose was 3.5 ± 1.7 mSv for the total MPI protocol. Correlations between CZT-SPECT and MRI were good to excellent for ejection fraction (r 2 = 0.77), end-diastolic (r 2 = 0.88) and end-systolic (r 2 = 0.93) volumes, and the analysis of segmental contractility correlated well between the two techniques (kappa score = 0.72 ± 0.02). CONCLUSION: LV function, assessed on a CZT camera with low injected activities and limited recording times, correlates well with the reference assessment from cardiac MRI.
Entities:
Keywords:
CZT camera; Myocardial perfusion imaging (MPI); Tc-99m Sestamibi; gated-SPECT; left ventricular function
Authors: Christian Vanhove; Philippe R Franken; Michel Defrise; Frank Deconinck; Axel Bossuyt Journal: Eur J Nucl Med Mol Imaging Date: 2002-02-19 Impact factor: 9.236
Authors: N David; P Y Marie; M Angioi; R M Rodriguez; N Hassan; P Olivier; A Grentzinger; G Karcher; O Claudon; Y Juillière; N Danchin; A Bertrand Journal: Eur J Nucl Med Date: 2000-07
Authors: Fatiha Maskali; Philippe R Franken; Sylvain Poussier; Nguyen Tran; Chris Vanhove; Henri Boutley; Hervé Le Gall; Gilles Karcher; Faïez Zannad; Patrick Lacolley; Pierre Y Marie Journal: J Nucl Med Date: 2006-02 Impact factor: 10.057