Literature DB >> 27672680

A Molecular Take on Malignant Rhabdoid Tumors.

Ming Tang1, Roel Gw Verhaak2.   

Abstract

The molecular basis for the clinical heterogeneity observed in patients with malignant rhabdoid tumors is unknown. Recently, two reports revealed molecular inter-tumor heterogeneity in teratoid/rhabdoid tumors (ATRTs) and extra-cranial MRTs (ecMRTs) using genomic, transcriptomic and epigenomic profiling. Distinct molecular subgroups were identified and new therapeutic targets were revealed.

Entities:  

Keywords:  malignant rhabdoid tumors; molecular analysis; pediatric cancer; sequencing

Year:  2016        PMID： 27672680      PMCID： PMC5035037          DOI： 10.1016/j.trecan.2016.04.003

Source DB:  PubMed          Journal:  Trends Cancer        ISSN： 2405-8025


  10 in total

1.  Swi/Snf chromatin remodeling/tumor suppressor complex establishes nucleosome occupancy at target promoters.

Authors:  Michael Y Tolstorukov; Courtney G Sansam; Ping Lu; Edward C Koellhoffer; Katherine C Helming; Burak H Alver; Erik J Tillman; Julia A Evans; Boris G Wilson; Peter J Park; Charles W M Roberts
Journal:  Proc Natl Acad Sci U S A       Date:  2013-05-30       Impact factor: 11.205

2.  Atypical Teratoid/Rhabdoid Tumors Are Comprised of Three Epigenetic Subgroups with Distinct Enhancer Landscapes.

Authors:  Pascal D Johann; Serap Erkek; Marc Zapatka; Kornelius Kerl; Ivo Buchhalter; Volker Hovestadt; David T W Jones; Dominik Sturm; Carl Hermann; Maia Segura Wang; Andrey Korshunov; Marina Rhyzova; Susanne Gröbner; Sebastian Brabetz; Lukas Chavez; Susanne Bens; Stefan Gröschel; Fabian Kratochwil; Andrea Wittmann; Laura Sieber; Christina Geörg; Stefan Wolf; Katja Beck; Florian Oyen; David Capper; Peter van Sluis; Richard Volckmann; Jan Koster; Rogier Versteeg; Andreas von Deimling; Till Milde; Olaf Witt; Andreas E Kulozik; Martin Ebinger; Tarek Shalaby; Michael Grotzer; David Sumerauer; Josef Zamecnik; Jaume Mora; Nada Jabado; Michael D Taylor; Annie Huang; Eleonora Aronica; Anna Bertoni; Bernhard Radlwimmer; Torsten Pietsch; Ulrich Schüller; Reinhard Schneppenheim; Paul A Northcott; Jan O Korbel; Reiner Siebert; Michael C Frühwald; Peter Lichter; Roland Eils; Amar Gajjar; Martin Hasselblatt; Stefan M Pfister; Marcel Kool
Journal:  Cancer Cell       Date:  2016-02-25       Impact factor: 31.743

3.  The role of INI1 and the SWI/SNF complex in the development of rhabdoid tumors: meeting summary from the workshop on childhood atypical teratoid/rhabdoid tumors.

Authors:  Jaclyn A Biegel; Ganjarn Kalpana; Erik S Knudsen; Roger J Packer; Charles W M Roberts; Carol J Thiele; Bernard Weissman; Malcolm Smith
Journal:  Cancer Res       Date:  2002-01-01       Impact factor: 12.701

4.  Genomic Classification of Cutaneous Melanoma.

Authors: 
Journal:  Cell       Date:  2015-06-18       Impact factor: 41.582

5.  Rhabdoid tumors in children: prognostic factors in 70 patients diagnosed in Germany.

Authors:  Harald Reinhard; Jennifer Reinert; Rita Beier; Rhoikos Furtwängler; Muhanat Alkasser; Stefan Rutkowski; Michael Frühwald; Ewa Koscielniak; Ivo Leuschner; Peter Kaatsch; Norbert Graf
Journal:  Oncol Rep       Date:  2008-03       Impact factor: 3.906

6.  Genome-Wide Profiles of Extra-cranial Malignant Rhabdoid Tumors Reveal Heterogeneity and Dysregulated Developmental Pathways.

Authors:  Hye-Jung E Chun; Emilia L Lim; Alireza Heravi-Moussavi; Saeed Saberi; Karen L Mungall; Mikhail Bilenky; Annaick Carles; Kane Tse; Inna Shlafman; Kelsey Zhu; Jenny Q Qian; Diana L Palmquist; An He; William Long; Rodrigo Goya; Michelle Ng; Veronique G LeBlanc; Erin Pleasance; Nina Thiessen; Tina Wong; Eric Chuah; Yong-Jun Zhao; Jacquie E Schein; Daniela S Gerhard; Michael D Taylor; Andrew J Mungall; Richard A Moore; Yussanne Ma; Steven J M Jones; Elizabeth J Perlman; Martin Hirst; Marco A Marra
Journal:  Cancer Cell       Date:  2016-03-14       Impact factor: 31.743

Review 7.  Epigenetic modulators, modifiers and mediators in cancer aetiology and progression.

Authors:  Andrew P Feinberg; Michael A Koldobskiy; Anita Göndör
Journal:  Nat Rev Genet       Date:  2016-03-14       Impact factor: 53.242

8.  A remarkably simple genome underlies highly malignant pediatric rhabdoid cancers.

Authors:  Ryan S Lee; Chip Stewart; Scott L Carter; Lauren Ambrogio; Kristian Cibulskis; Carrie Sougnez; Michael S Lawrence; Daniel Auclair; Jaume Mora; Todd R Golub; Jaclyn A Biegel; Gad Getz; Charles W M Roberts
Journal:  J Clin Invest       Date:  2012-07-17       Impact factor: 14.808

9.  Molecular Profiling Reveals Biologically Discrete Subsets and Pathways of Progression in Diffuse Glioma.

Authors:  Michele Ceccarelli; Floris P Barthel; Tathiane M Malta; Thais S Sabedot; Sofie R Salama; Bradley A Murray; Olena Morozova; Yulia Newton; Amie Radenbaugh; Stefano M Pagnotta; Samreen Anjum; Jiguang Wang; Ganiraju Manyam; Pietro Zoppoli; Shiyun Ling; Arjun A Rao; Mia Grifford; Andrew D Cherniack; Hailei Zhang; Laila Poisson; Carlos Gilberto Carlotti; Daniela Pretti da Cunha Tirapelli; Arvind Rao; Tom Mikkelsen; Ching C Lau; W K Alfred Yung; Raul Rabadan; Jason Huse; Daniel J Brat; Norman L Lehman; Jill S Barnholtz-Sloan; Siyuan Zheng; Kenneth Hess; Ganesh Rao; Matthew Meyerson; Rameen Beroukhim; Lee Cooper; Rehan Akbani; Margaret Wrensch; David Haussler; Kenneth D Aldape; Peter W Laird; David H Gutmann; Houtan Noushmehr; Antonio Iavarone; Roel G W Verhaak
Journal:  Cell       Date:  2016-01-28       Impact factor: 41.582

10.  Inhibiting Drivers of Non-mutational Drug Tolerance Is a Salvage Strategy for Targeted Melanoma Therapy.

Authors:  Michael P Smith; Holly Brunton; Emily J Rowling; Jennifer Ferguson; Imanol Arozarena; Zsofia Miskolczi; Jessica L Lee; Maria R Girotti; Richard Marais; Mitchell P Levesque; Reinhard Dummer; Dennie T Frederick; Keith T Flaherty; Zachary A Cooper; Jennifer A Wargo; Claudia Wellbrock
Journal:  Cancer Cell       Date:  2016-03-14       Impact factor: 38.585
  10 in total

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